Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Gary E Gibson"'
Autor:
Howard H Feldman, José A Luchsinger, Gabriel C Léger, Curtis Taylor, Diane M Jacobs, David P Salmon, Steven D Edland, Karen Messer, Carolyn Revta, Sarah A Flowers, Kerry S Jones, Albert Koulman, Kevin E Yarasheski, Philip B Verghese, Venky Venkatesh, Henrik Zetterberg, January Durant, Jody-Lynn Lupo, Gary E Gibson, ADCS BenfoTeam Study Group
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0302998 (2024)
BackgroundBenfotiamine provides an important novel therapeutic direction in Alzheimer's disease (AD) with possible additive or synergistic effects to amyloid targeting therapeutic approaches.ObjectiveTo conduct a seamless phase 2A-2B proof of concept
Externí odkaz:
https://doaj.org/article/1adfda9ed09d49c99461ba5018b477fc
Autor:
Nima N Naseri, Joseph Bonica, Hui Xu, Larry C Park, Jamshid Arjomand, Zhengming Chen, Gary E Gibson
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0160384 (2016)
Metabolic dysfunction is well-documented in Huntington's disease (HD). However, the link between the mutant huntingtin (mHTT) gene and the pathology is unknown. The tricarboxylic acid (TCA) cycle is the main metabolic pathway for the production of NA
Externí odkaz:
https://doaj.org/article/55ce99018e394d29bc1b712d904d5c15
Autor:
Yun Yang, Victor Tapias, Diana Acosta, Hui Xu, Huanlian Chen, Ruchika Bhawal, Elizabeth T. Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, Jianer Chen, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram Haroutunian, M. Flint Beal, David Eliezer, Sheng Zhang, Gary E. Gibson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Succinylation is a metabolism-associated post-translational protein modification. Here the authors describe changes to the succinylation of proteins in the brain of individuals with Alzheimer’s disease.
Externí odkaz:
https://doaj.org/article/8849caad15a2425b9a9463a3e1b93bff
Autor:
Hussein N. Yassine, Wade Self, Bilal E. Kerman, Giulia Santoni, NandaKumar Navalpur Shanmugam, Laila Abdullah, Lesley R. Golden, Alfred N. Fonteh, Michael G. Harrington, Johannes Gräff, Gary E. Gibson, Raj Kalaria, Jose A. Luchsinger, Howard H. Feldman, Russell H. Swerdlow, Lance A. Johnson, Benedict C. Albensi, Berislav V. Zlokovic, Rudolph Tanzi, Stephen Cunnane, Cécilia Samieri, Nikolaos Scarmeas, Gene L. Bowman
Publikováno v:
Alzheimer's & Dementia. 19:1041-1066
Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610baf6bd459f153d922cbd98565ac79
https://doi.org/10.1002/alz.12845
https://doi.org/10.1002/alz.12845
Publikováno v:
Frontiers in Medicine. 9
of the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8598fed65dc27e6671b4c0b6cb7b65
https://doi.org/10.3389/fmed.2022.1033272
https://doi.org/10.3389/fmed.2022.1033272
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13188, p 13188 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13188
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13188
International Journal of Molecular Sciences
Serum metabolomics and lipidomics are powerful approaches for discovering unique biomarkers in various diseases and associated therapeutics and for revealing metabolic mechanisms of both. Treatment with Benfotiamine (BFT), a thiamine prodrug, for one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8ec12ea96bef51616ccff482b8ef3a
https://www.mdpi.com/1422-0067/22/24/13188
https://www.mdpi.com/1422-0067/22/24/13188
Autor:
Lichuan Yang, Qingli Shi, Daniel J. Ho, Anatoly A. Starkov, Elizabeth J. Wille, Hui Xu, H.L. Chen, Steven Zhang, Cliona M. Stack, Noel Y. Calingasan, Gary E. Gibson, M. Flint Beal
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 2, Pp 320-330 (2009)
The activity of a key mitochondrial tricarboxylic acid cycle enzyme, α-ketoglutarate dehydrogenase complex (KGDHC), declines in many neurodegenerative diseases. KGDHC consists of three subunits. The dihydrolipoyl succinyl transferase (DLST) componen
Externí odkaz:
https://doaj.org/article/e589e19bf5b940afab0ecdf08e74249c
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 2, Pp 353-362 (2007)
Abnormalities in oxidative metabolism and reductions of thiamine-dependent enzymes accompany many age-related neurodegenerative diseases. Thiamine deficiency (TD) produces a cascade of events including mild impairment of oxidative metabolism, activat
Externí odkaz:
https://doaj.org/article/5a5a9b3658194f5ba2a77c9ce29a4365
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce74a30e2b10071357f95c6904f31240
https://doi.org/10.1016/b978-0-12-819460-7.00137-7
https://doi.org/10.1016/b978-0-12-819460-7.00137-7
Publikováno v:
Movement Disorders. 36:2003-2004
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3240bea8c0db28f42a7ebefeafda4474
https://doi.org/10.1002/mds.28743
https://doi.org/10.1002/mds.28743