Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gary D. Swergold"'
Publikováno v:
The American Journal of Human Genetics. 72:739-748
The genomic evolution and causes of phenotypic variation among humans and great apes remain largely unknown, although the phylogenetic relationships among them have been extensively explored. Previous studies that focus on differences at the amino ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b9adf3b432b3afd5e62d65e49793ef
https://doi.org/10.1086/368275
https://doi.org/10.1086/368275
Autor:
Donna M. Sassaman, Gary D. Swergold, Ralph J. DeBerardinis, John V. Moran, Haig H. Kazazian, Thierry Naas, Michelle L. Kimberland, Beth A. Dombroski, Abram Gabriel
Publikováno v:
Nature Genetics. 16:37-43
Using a selective screening strategy to enrich for active L1 elements, we isolated 13 full-length elements from a human genomic library. We tested these and two previously-isolated L1s (L1.3 and L1.4) for reverse transcriptase (RT) activity and the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53eefbdc3c844dbcf68bf00bac718329
https://doi.org/10.1038/ng0597-37
https://doi.org/10.1038/ng0597-37
Publikováno v:
Gene. 135:183-188
Among the 10(5) LINE-1 sequences (L1Hs) in the human genome are one or more 6-kb segments that are active retrotransposons. Expression of these retrotransposons appears to be favored in cells of germ line origin, as well as in some other tumor cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b52d8b3d1fa28c6cad76bd4baa3bb7
https://doi.org/10.1016/0378-1119(93)90064-a
https://doi.org/10.1016/0378-1119(93)90064-a
Autor:
Dmitry Goldgaber, Patrick O. Brown, H. Baron, W. R. McCombie, Gary D. Swergold, C. J. Gibbs, Peter R. Wills, Larisa Cervenakova, Lev G. Goldfarb, D. C. Gajdusek
Publikováno v:
Scopus-Elsevier
The PRNP gene, encoding the amyloid precursor protein that is centrally involved in Creutzfeldt-Jakob disease (CJD), has an unstable region of five variant tandem octapeptide coding repeats between codons 51 and 91. We screened a total of 535 individ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cbb19b4e187bd4dd5ce004cf31ae36
https://doi.org/10.1073/pnas.88.23.10926
https://doi.org/10.1073/pnas.88.23.10926
Autor:
John A. Phillips, Kathy Hudson, Patricia J. Murphy, Bernhard H. F. Weber, Monique K. Mansoura, Mary Jo Ellis Kahn, E. Crowley, Francis S. Collins, Gary D. Swergold, Leslie G. Biesecker, Mark A. Rothstein, Patricia Barr, J. Murray, Karen H. Rothenberg, Barbara P. Fuller, Judy Garber, Jill E. Stopfer
Publikováno v:
Science. 285:1359-1361
Rapid advances in genetics research and the emerging applications to medical practice have heightened public awareness and public concerns about who will have access to this information and how it will be used. In addition to concerns about the priva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a182ed6e99f3b5388220ca6ed44fad5b
https://doi.org/10.1126/science.285.5432.1359
https://doi.org/10.1126/science.285.5432.1359
Publikováno v:
Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 19(3)
In order to determine the reliability of a self-administered instrument to diagnose excessive sweating conditions, including palmar hyperhidrosis (PH), we designed two successive questionnaires and compared responses with physical examination and swe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1709650a4fea96b736324a69fe56155
https://pubmed.ncbi.nlm.nih.gov/19479303
https://pubmed.ncbi.nlm.nih.gov/19479303
Autor:
Gary D. Swergold
Publikováno v:
Molecular and Cellular Biology. 10:6718-6729
A constructed human LINE-1 (L1Hs) element containing intact 5' and 3' untranslatable regions and an in-frame fusion between the L1Hs open reading frame 1 and the bacterial lacZ gene (p1LZ) was found to promote the expression of beta-galactosidase in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f3237335be8460a684c762eb0655d9
https://doi.org/10.1128/mcb.10.12.6718-6729.1990
https://doi.org/10.1128/mcb.10.12.6718-6729.1990
Autor:
Gary D. Swergold, B A Dombroski, Maxine F. Singer, Ronald E. Thayer, Thomas G. Fanning, D M Leibold
Publikováno v:
Proceedings of the National Academy of Sciences. 87:6990-6994
The LINE-1 (L1) family of interspersed DNA sequences found throughout the human genome (L1 Homo sapiens, L1Hs) includes active transposable elements. Current models for the mechanism of transposition involve reverse transcription of an RNA intermedia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1fa9b0f5c6ab3598631e7112277e485
https://doi.org/10.1073/pnas.87.18.6990
https://doi.org/10.1073/pnas.87.18.6990
Autor:
Patricia J. Murphy, Francis S. Collins, Mary Claire King, Kathy L. Hudson, Gary D. Swergold, Rita Cunningham, Troy Duster, Karen H. Rothenberg, Beth A. Fine, Mark Rothstein, Mary Jo Ellis Kahn, Barbara P. Fuller
Publikováno v:
Science. 275:1755-1757
The use of genetic information in the workplace poses societal risks that have an impact on employment possibilities, health insurance, and privacy. Individuals who might otherwise believe they can benefit from genetic testing may decline it because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3255fd1d6b468edf2db15311e4ae48af
https://doi.org/10.1126/science.275.5307.1755
https://doi.org/10.1126/science.275.5307.1755
The amplification of DNA by LINE-1 (L1) retrotransposons has created a large fraction of the human genome. To better understand their role in human evolution we endeavored to delineate the L1 elements that have amplified since the emergence of the ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94116cd5b188aa7d0819b138eb40475
https://europepmc.org/articles/PMC124962/
https://europepmc.org/articles/PMC124962/
