Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Gary D. Madding"'
1
Efficient Crystallization-Induced Dynamic Resolution of α-Substituted Carboxylic Acids
Autor: Susanne Kiau, Gary D. Madding, Robert P. Discordia, Victor W. Rosso, Francis J. Okuniewicz, John J. Venit
Publikováno v: The Journal of Organic Chemistry. 69:4256-4261
Herein we present a novel route to enantiomerically enriched chiral alpha-substituted carboxylic acids by crystallization-induced dynamic resolution (CIDR) of their diastereomeric salts with chiral amines. Thus, the racemic alpha-bromo acid 3 is conv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff41d8870af8e90045b6bea214dfcc2
https://doi.org/10.1021/jo049849e
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2
Regio- and stereoselective ring opening of epoxide with cyanoguanidine dianions, a facile synthesis of the KATP opener BMS-180448
Autor: Gary D. Madding, Bang-Chi Chen, J. Gregory Reid, Tonya P Robinson, Michael J. Humora, William Early, Sandra L. Quinlan, John J. Venit, Edward J. Delaney, Paul A. Jass, William J. Winter
Publikováno v: Tetrahedron: Asymmetry. 9:1337-1340
BMS-180448, (3S,4R)- 2 , was prepared in 63% yield via a facile method which involved a new regio- and stereoselective ring opening of epoxide (3S,4S)- 12 with the potassium dianion of cyanoguanidine 11 .
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb3443a42e03bc6d36c91c2e715a38a1
https://doi.org/10.1016/s0957-4166(98)00116-5
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4
ChemInform Abstract: Condensation Reactions of Activated Picolines with Anthranilate Esters and o-Nitrobenzaldehyde: Improved Syntheses of the Antiarrhythmic Drug Encainide
Autor: Mary E. Wire, Richard H. Spector, John L. Dillon, Gary D. Madding
Publikováno v: ChemInform. 24
Two new and improved syntheses of the antiarrhythmic drug Encainide, 1, are presented. The first approach is based on the condensation of 2-picolyllithium with the p-anisoyl amide of methyl anthranilate, 3, followed by a series of catalytic hydrogena
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de27a9c8f9da44b76cbe50791ca4c16e
https://doi.org/10.1002/chin.199349189
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5
Ethyl Hydroxymethyleneacetate, Sodium Salt
Autor: Gary D. Madding
Publikováno v: e-EROS Encyclopedia of Reagents for Organic Synthesis
[58986-28-0] C5H7NaO3 (MW 138.11) InChI = 1S/C5H8O3.Na/c1-2-8-5(7)3-4-6;/h3-4,6H,2H2,1H3;/q;+1/p-1/b4-3-; InChIKey = ITWVTNYFGKFDGE-LNKPDPKZSA-M (a three-carbon β-dicarbonyl building block) Alternate Names: ethyl formylacetate, sodium salt. Solubili
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de1cfea9a3dce01b1dc1614b43f21b4f
https://doi.org/10.1002/047084289x.re091
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6
Synthesis and X-Ray crystal structure of a 2,4,5-trisubstituted 1,2,4-triazolin-3-one
Autor: B. Lee, David W. Smith, Robert I. Sheldon, Gary D. Madding
Publikováno v: Journal of Heterocyclic Chemistry. 22:1121-1126
The synthesis and x-ray crystal structure of BMY 13754, a 1,2,4-triazolin-3-one under clinical evaluation as an antidepressant agent, is described. Several synthetic strategies are discussed.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b1d7d6246f36ac2482c3dd63eab4942
https://doi.org/10.1002/jhet.5570220440
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