Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Gary D. Glick"'
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Targeting the mitochondrial enzyme FoF1-ATP synthase and modulating its catalytic activities with small molecules is a promising new approach for treatment of autoimmune diseases. The immunomodulatory compound Bz-423 is such a drug that binds to subu
Externí odkaz:
https://doaj.org/article/0349291195a549bcab430cd6af86262f
Myc proteins regulate cell growth and are oncogenic in many cancers. Although these proteins are validated molecular anticancer targets, new therapies aimed at modulating myc have yet to emerge. A benzodiazepine (Bz-423) that was discovered in effort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b91134d75c22d795003cede7e2791bf
https://doi.org/10.1158/0008-5472.c.6495227
https://doi.org/10.1158/0008-5472.c.6495227
Supplementary Table 1 from The Immunomodulatory Benzodiazepine Bz-423 Inhibits B-Cell Proliferation by Targeting c-Myc Protein for Rapid and Specific Degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e2ed41ce5d254bd7cbea8ab980541f
https://doi.org/10.1158/0008-5472.22366628
https://doi.org/10.1158/0008-5472.22366628
Supplementary Figure 1 from The Immunomodulatory Benzodiazepine Bz-423 Inhibits B-Cell Proliferation by Targeting c-Myc Protein for Rapid and Specific Degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033abce2d4279e36193f0815d3a7ed1d
https://doi.org/10.1158/0008-5472.22366634.v1
https://doi.org/10.1158/0008-5472.22366634.v1
Autor:
Gary D. Glick
Publikováno v:
Current Protocols in Nucleic Acid Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2598ea2769030b128451dff12d15ba6d
https://pubmed.ncbi.nlm.nih.gov/35472857
https://pubmed.ncbi.nlm.nih.gov/35472857
Autor:
Jie Gao, Skalitzky Donald James, Bing Yang, Junping Zhang, Charles A Lesch, Xiaolong Tian, Chenxi Qiao, Chad A. Van Huis, Clarke Taylor, Laura L. Carter, Tao Zheng, Weiping Zou, Rodney W. Morgan, Peter L. Toogood, Yahong Wang, Kellie Demock, Gary D. Glick, Xiao Hu, Jacques Moisan, Chrystal M. Paulos, JoAnn Scatina, Changxin Huo, Thomas Daniel Aicher, Alexander R. Hurd, Omar M Beleh, Ling-Yang Hao
Publikováno v:
Journal of medicinal chemistry. 64(18)
Retinoic acid receptor-related orphan receptor γ (RORc, RORγ, or NR1F3) is the nuclear receptor master transcription factor that drives the function and development of IL-17-producing T helper cells (Th17), cytotoxic T cells (Tc17), and subsets of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2e4225821f461df08e3b04715e7805
https://pubmed.ncbi.nlm.nih.gov/34499493
https://pubmed.ncbi.nlm.nih.gov/34499493
Autor:
Chuck A. Lesch, Ling Yang Hao, Ivan Monteleone, Anthony W. Opipari, Wenpu Zhao, Oksana Mashadova, Gary D. Glick, Mark A. Spahr, John M. Asara, Giovanni Monteleone, Costas A. Lyssiotis, Brian Sanchez, Irene Marafini, Luigi Franchi, Xiao Hu, Kellie Demock, Xikui Liu, Min Yuan, Harinder Singh, Aditi Kulkarni, Laura L. Carter
Publikováno v:
The Journal of Immunology. 198:2735-2746
Integration of signaling and metabolic pathways enables and sustains lymphocyte function. Whereas metabolic changes occurring during T cell activation are well characterized, the metabolic demands of differentiated T lymphocytes are largely unexplore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba90584d43c28b544a24097ef938ec6
https://doi.org/10.4049/jimmunol.1600810
https://doi.org/10.4049/jimmunol.1600810
Autor:
Laura Engstrom, Kyle J. Piers, Kenneth Jay Barr, Renu Jain, Dallas C. Jones, Huseyin Mehmet, Heidi Ferguson, Gary D. Glick, John S. Mudgett, Richard Miller, Xiao Hu, Hongjun Zhang, I-Ming Wang, Abbas Hawwari, Craig C. Correll, Barbara Joyce-Shaikh, Razvan Cristescu, Yanxia Guo, Daniel J. Cua, Gretchen A. Baltus, Yi Chen, Thomas Daniel Aicher, Dennis M. Zaller, Laura L. Carter, Laxminarayan G Hegde, Kenzie D. MacIsaac
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3206-3218 (2016)
Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4+CD8+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0611f033ecc5354d2efdd17e30b783f
http://www.sciencedirect.com/science/article/pii/S2211124716316473
http://www.sciencedirect.com/science/article/pii/S2211124716316473
Autor:
H. Martin Seidel, Matthew Mangan, Gary D. Glick, William R. Roush, Edward James Olhava, Eicke Latz
Publikováno v:
Nature reviews / Drug discovery 17(8), 588-606 (2018). doi:10.1038/nrd.2018.97
Danger signals are a hallmark of many common inflammatory diseases, and these stimuli can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR- and pyrin domain-containing 3). Once activated, NLRP3 nucleates the assem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452c81946964c3bb37c11c4f5711bbe1
Autor:
Charles A Lesch, Clarke Bentley Taylor, Ling Yang Hao, Xikui Liu, Rodrigue Rossignol, Craig A. Byersdorfer, Victor Tkachev, Gary D. Glick, Daniel Wahl, James L.M. Ferrara, Laszlo G. Boros, Costas A. Lyssiotis, Brian Sanchez, Alexander Hurd, Anthony W. Opipari
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:298-307
T-cell activation requires increased ATP and biosynthesis to support proliferation and effector function. Most models of T-cell activation are based on in vitro culture systems and posit that aerobic glycolysis is employed to meet increased energetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62ee2574e104f8c8a74db6b80856842
https://doi.org/10.1124/jpet.114.218099
https://doi.org/10.1124/jpet.114.218099