Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Gary D. Bren"'
Autor:
Rahul Sampath, Nathan W Cummins, Sekar Natesampillai, Gary D Bren, Thomas D Chung, Jason Baker, Keith Henry, Amélie Pagliuzza, Andrew D Badley
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179327 (2017)
HIV persists because a reservoir of latently infected CD4 T cells do not express viral proteins and are indistinguishable from uninfected cells. One approach to HIV cure suggests that reactivating HIV will activate cytotoxic pathways; yet when tested
Externí odkaz:
https://doaj.org/article/fbe979067c1142899383a6144c7300a9
Autor:
Maike Sperk, Ujjwal Neogi, Nicole Kogan, Anders Sönnerborg, Steve Deeks, Enrique Garcia-Rivera, Andrew D. Badley, Eric C. Polley, Sekar Natesampillai, Nathan W. Cummins, Gary D. Bren, Ana C. Paim
Publikováno v:
AIDS (London, England), vol 33, iss 11
OBJECTIVE Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) dependent apoptosis has been implicated in CD4 T-cell death and immunologic control of HIV-1 infection. We have described a splice variant called TRAILshort, which is a dominan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d544bd6a2c4fb3fb1ad4ef20e9c1fb
https://doi.org/10.1097/qad.0000000000002279
https://doi.org/10.1097/qad.0000000000002279
Autor:
Andrew D. Badley, Aswath P. Chandrasekar, Ana C. Paim, Gary D. Bren, Hans-Peter Kiem, Sharon R Lewin, Nathan W. Cummins, Sekar Natesampillai
Publikováno v:
J Immunol
CD4 T cells from HIV-1 infected patients die at excessive rates compared to those from uninfected patients, causing immunodeficiency. We previously identified a dominant negative ligand that antagonizes the TRAIL-dependent pathway of cell death, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6005fc315ae8b7e375ae000ad5303b2e
https://doi.org/10.4049/jimmunol.1900271
https://doi.org/10.4049/jimmunol.1900271
Autor:
Thomas D.Y. Chung, Jeff R. Anderson, Stephen P. Burke, Fatma Aboulnasr, David J. Katzmann, Michele K. Smart, Govindarajan Rajagopalan, Sekar Natesampillai, Nathan W. Cummins, Ashton Krogman, Zilin Nie, Gary D. Bren, Andrew D. Badley
Publikováno v:
The Journal of Immunology. 200:1110-1123
TNF-related apoptosis-inducing ligand (TRAIL) was initially described to induce apoptosis of tumor cells and/or virally infected cells, although sparing normal cells, and has been implicated in the pathogenesis of HIV disease. We previously identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f32add6c053fbdad2644f69cea88303d
https://doi.org/10.4049/jimmunol.1701113
https://doi.org/10.4049/jimmunol.1701113
Autor:
Stacey A Rizza, Kishore B Challagundla, Sekar Natesampillai, Gary D Bren, Jaromir Sykora, Henning Walczak, Andrew D Badley
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27171 (2011)
The mechanism by which HIV and HCV cooperatively accelerate hepatocyte damage is not clearly understood; however, each virus affects the TRAIL: TRAIL-receptor system. We, therefore, questioned whether the independent effects of HCV and HIV combine to
Externí odkaz:
https://doaj.org/article/9b38212406d244b0821b0672af30d909
Autor:
Nathan W Cummins, Anna Klicpera, Amy M Sainski, Gary D Bren, Sundeep Khosla, Jennifer J Westendorf, Andrew D Badley
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24876 (2011)
Patients with HIV infection have decreased numbers of osteoblasts, decreased bone mineral density and increased risk of fracture compared to uninfected patients; however, the molecular mechanisms behind these associations remain unclear. We questione
Externí odkaz:
https://doaj.org/article/8d1ea0a6bb65496fac755409464d7227
Autor:
Sekar Natesampillai, Zilin Nie, Nathan W Cummins, Dirk Jochmans, Gary D Bren, Jonathan B Angel, Andrew D Badley
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001213 (2010)
In medicine, understanding the pathophysiologic basis of exceptional circumstances has led to an enhanced understanding of biology. We have studied the circumstance of HIV-infected patients in whom antiretroviral therapy results in immunologic benefi
Externí odkaz:
https://doaj.org/article/143cdd7991584c8080240d814977a14a
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4875 (2009)
HIV envelope glycoprotein gp120 causes cellular activation resulting in anergy, apoptosis, proinflammatory cytokine production, and through an unknown mechanism, enhanced HIV replication.We describe that the signals which promote apoptosis are also r
Externí odkaz:
https://doaj.org/article/0b43dcd505e6474cbfed6059da963517
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4623 (2009)
HIV infected patients have an increased susceptibility to liver disease due to Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), alcoholic, and non-alcoholic steatohepatitis. Clinically, this results in limited options for antiretroviral therapy and
Externí odkaz:
https://doaj.org/article/5aebd2e0ec60413d97d34ea6d259a2bf
Autor:
Gary D Bren, Joe Whitman, Nathan Cummins, Brett Shepard, Stacey A Rizza, Sergey A Trushin, Andrew D Badley
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2112 (2008)
Acute HIV-1 infection of CD4 T cells often results in apoptotic death of infected cells, yet it is unclear what evolutionary advantage this offers to HIV-1. Given the independent observations that acute T cell HIV-1 infection results in (1) NF-kappaB
Externí odkaz:
https://doaj.org/article/b94c0e912a43428e8d71520e351b5e55