Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gary D. Bowers"'
Autor:
Susan L Ford, Gary D Bowers, Lindsey O. Webster, Elizabeth P Gould, Joseph W. Polli, Melinda J. Reese, Joan E. Humphreys
Publikováno v:
Xenobiotica. 46:445-456
1. Cabotegravir (CAB; GSK1265744) is a potent HIV integrase inhibitor in clinical development as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. 2. This work investigated if CAB was a substrate for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee029c6cb38b7a6d4adef529a07b55e
https://doi.org/10.3109/00498254.2015.1081993
https://doi.org/10.3109/00498254.2015.1081993
Autor:
Phuong Huynh, David S. Wagner, Lee Moss, William Spreen, Yu Lou, Gary D Bowers, Susan L. Ford, Amanda G. Culp, Rennan Pan, Melinda J. Reese, Glenn Tabolt, David A. Margolis, Stephen C. Piscitelli, Elizabeth Gould
Publikováno v:
Xenobiotica. 46:147-162
1. Cabotegravir [(3S,11aR)-N-[(2,4-difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide] is an HIV-1 integrase inhibitor under development as a tablet for both oral lead-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bf26e1cbb6454fe0e0bcb222d0ef45
https://doi.org/10.3109/00498254.2015.1060372
https://doi.org/10.3109/00498254.2015.1060372
Autor:
Bao Hoang, Stephen C. Lenhard, Valeriu Damian, Hasan Alsaid, M. Reid Groseclose, Stephen Castellino, Beat M. Jucker, Gary D. Bowers, Mary V. Rambo, Manish Gupta, Fang Xie
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 268
Long-Acting Parenterals (LAPs) have been used in the clinic to provide sustained therapeutic drug levels at a target site, and thereby reducing the frequency of dosing required. In an effort to understand the factors associated with long-acting cabot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58d1430f17a0ba785ba00bc8e7649e0
https://pubmed.ncbi.nlm.nih.gov/29042321
https://pubmed.ncbi.nlm.nih.gov/29042321
Publikováno v:
Xenobiotica. 45:60-70
1. Plasma clearance of dolutegravir, an unboosted HIV-1 integrase inhibitor, was low in rat and monkey (0.23 and 2.12 mL/min/kg, respectively) as was the volume of distribution (0.1 and 0.28 L/kg, respectively) with terminal elimination half-life app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037d800f1bc43986c18603e2ce1d3fa1
https://doi.org/10.3109/00498254.2014.942409
https://doi.org/10.3109/00498254.2014.942409
Autor:
Gary D Bowers, Lakshmi S. Vasist Johnson, Derek J. Nunez, Jiang Lin, Elizabeth Gould, Rebecca J. Hodge
Publikováno v:
Clinical Pharmacology in Drug Development. 2:213-222
TGR5 is a bile acid receptor and a potential target for the treatment of type 2 diabetes (T2D). We report here the safety, pharmacokinetics, and pharmacodynamic effects of a selective TGR5 agonist, SB-756050, in patients with T2D. Fifty-one subjects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9d3e3cb6e4b0b5f08d396a36f9e8563
https://doi.org/10.1002/cpdd.34
https://doi.org/10.1002/cpdd.34
Publikováno v:
Bioanalysis. 5:463-479
Effective characterization of drug metabolites in complex biological matrices is facilitated by mass spectrometers with high resolving power, mass accuracy and sensitivity. This review begins with an overview of high-resolution MS terminology and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c4d58aa0f347b6d1e5a4982c0dd615
https://doi.org/10.4155/bio.13.3
https://doi.org/10.4155/bio.13.3
Autor:
Wenli Tao, J. Sigafoos, Robert L. Dobbins, Anita Kapur, Stephen Castellino, David S. Wagner, Joan E. Humphreys, Joseph W. Polli, Melinda J. Reese, Elizabeth K. Hussey, Gary D Bowers, Amanda G. Culp, Robin L. O'Connor Semmes
Publikováno v:
Drug Metabolism and Disposition. 40:2090-2101
Remogliflozin etabonate is the ester prodrug of remogliflozin, a selective sodium-dependent glucose cotransporter-2 inhibitor. This work investigated the absorption, metabolism, and excretion of [(14)C]remogliflozin etabonate in humans, as well as th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e117e38342441abf69a32eb67645b2a1
https://doi.org/10.1124/dmd.112.047258
https://doi.org/10.1124/dmd.112.047258
Autor:
Gary D Bowers
Publikováno v:
Bioanalysis. 3:263-267
The Conference on Small Molecule Science (CoSMoS), organized by the Society for Small Molecule Science (a 501(c)(3) nonprofit chartered organization), was held in Portland, Oregon, USA, on the 27–29 September 2010. The meeting is focused on analyti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::192f39e464b753f9f9a44e5b0e4acd7d
https://doi.org/10.4155/bio.10.200
https://doi.org/10.4155/bio.10.200
Autor:
Lee Moss, Cosette J. Serabjit-Singh, Andrea M. Sefler, J. Sigafoos, Mark de Serres, Stephen Castellino, Gary D Bowers
Publikováno v:
Xenobiotica. 40:437-445
GW695634 is the prodrug of GW678248, a novel non-nucleoside reverse transcriptase inhibitor with potent antiviral activity against HIV/AIDS efavirenz- and nevirapine-resistant viruses. In mice, rats, and monkeys following oral administration of [(14)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f01a8e957a82d7f8b9707c9d1ae8ca6
https://doi.org/10.3109/00498251003770578
https://doi.org/10.3109/00498251003770578
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 354(2)
Blood cells are considered an important distributional compartment for metformin based on the high blood-to-plasma partition ratio (B/P) in humans (>10 at Cmin). However, literature reports of metformin's intrinsic in vitro B/P values are lacking. At
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1a3c516ca78408df93f2f8d4257530
https://pubmed.ncbi.nlm.nih.gov/26062557
https://pubmed.ncbi.nlm.nih.gov/26062557