Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gary Cavallo"'
Autor:
Nadine Tare, Gerry Kaplan, Aruna Railkar, Anjula Pamidimukkala, Karl Frank, Gary Cavallo, Duk Soon Choi, Louise Gerber, Louis M. Renzetti, Jianping Lou, Jefferson Wright Tilley, Achyutharao Sidduri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1036-1040
From a series of N-acyl 4-(3-pyridonyl)phenylalanine derivatives of 4, the trifluoromethyl derivative 28 was identified as a potent, dual acting alpha4 integrin antagonist with activity in primate models of allergic asthma. Investigation of a series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08c5a8da0eaac2bf6512608278d3b51
https://doi.org/10.1016/j.bmcl.2012.12.019
https://doi.org/10.1016/j.bmcl.2012.12.019
Autor:
Duk Soon Choi, Louise Gerber, Jianping Lou, Louis M. Renzetti, Karl Frank, Achyutharao Sidduri, Aruna Railkar, Anjula Pamidimukkala, Gary Cavallo, Jefferson Wright Tilley, Nadine Tare
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1026-1031
N-Acyl 4-(5-pyrimidine-2,4-dionyl)phenylalanine derivatives of type 4 were designed to replace the 2,6-dichlorobenzoylamine portion of compound 1 in order to identify novel compounds with improved potency against α4-integrins. Several derivatives we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b26e172df191cd396f104c96ab6eb0
https://doi.org/10.1016/j.bmcl.2012.12.026
https://doi.org/10.1016/j.bmcl.2012.12.026
Autor:
Tina Molinaro, Robert Alan Goodnow, Louis M. Renzetti, Alexandra Hicks, Satish Choudhry, Xin Wei, Gesine J. Hermann, Qi Qiao, Anjula Pamidimukkala, A. Robert Catala, Maureen Hargaden, Jian Ping Lou, Nadine Tare, John O’Neil, Ueli Gubler, Karen Pozzani, David J Moore, Jennifer Santiago, Ruben Marcano, Paul Gillespie, Rachid Hamid, Noal Cohen, Hyesun Oh, Lisa C. F. Chao, Laura Singer, Jefferson Wright Tilley, Romyr Dominique, Grazyna Kurylko, Ying L. Li, Radhika Venkat, Achyutharao Sidduri, Matthew Blake Wright, Ann F. Hoffman, Shahid Tannu, Gary Cavallo, Nader Fotouhi, Thomas Egan, Martin Lamb, Jessica D. Ventre, Agnieszka Kowalczyk, D Lavelle, Helena Mancebo
Publikováno v:
Journal of Medicinal Chemistry. 53:3502-3516
The inhibition of LTB(4) binding to and activation of G-protein-coupled receptors BLT1 and BLT2 is the premise of a treatment for several inflammatory diseases. In a lead optimization effort starting with the leukotriene B(4) (LTB(4)) receptor antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f954d2982302b35c7516d54421fb833
https://doi.org/10.1021/jm1001919
https://doi.org/10.1021/jm1001919
Autor:
Anjula Pamidimukkala, Jian Ping Lou, Paul Gillespie, Rachid Hamid, Hyesun Oh, Thomas H. March, D Lavelle, Lisa C. F. Chao, Tina Molinaro, Matthew Blake Wright, Martin Brovarney, A. Robert Catala, John O’Neil, Agnieszka Kowalczyk, Louis M. Renzetti, Nader Fotouhi, Maureen Hargaden, John Satjawatcharaphong, Karen Pozzani, Xin Wei, Thomas Egan, Radhika Venkat, Ruben Marcano, Shahid Tannu, Karim Dabbagh, Helena Mancebo, Laura Singer, Martin Lamb, David J Moore, Jessica D. Ventre, Janet M. Benson, Ying L. Li, Jennifer Santiago, Ann F. Hoffman, Alexandra Hicks, Gary Cavallo, Jose M. Lora, Robert Alan Goodnow, Ueli Gubler, Romyr Dominique, Achyutharao Sidduri, Nadine Tare, Qi Qiao, Grazyna Kurylko
Publikováno v:
Prostaglandinsother lipid mediators. 92(1-4)
Asthma, chronic obstructive pulmonary disease (COPD) and acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are characterized by neutrophilic inflammation and elevated levels of leukotriene B4 (LTB4). However, the exact role of LTB4 pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a72bd708fcaa8a3eadcb8c1fcef6fbe
https://pubmed.ncbi.nlm.nih.gov/20214997
https://pubmed.ncbi.nlm.nih.gov/20214997
Autor:
Shahid Tannu, Louis M. Renzetti, Achyutharao Sidduri, Li Chen, Jefferson Wright Tilley, Gary Cavallo, Nadine Tare
Publikováno v:
Journal of Allergy and Clinical Immunology. 113:S221
Rationale The dual α4/β1-α4/β7 intergrin antagonist, RO0270608, the active free acid of the investigational asthma controller R411, has shown antiinflammatory activity in previous studies. This study further investigates the importance of dual vs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e206a4eac5887646feb26bf68cbcc9fd
https://doi.org/10.1016/j.jaci.2004.01.248
https://doi.org/10.1016/j.jaci.2004.01.248
Publikováno v:
Proceedings, annual meeting, Electron Microscopy Society of America. 45:876-877
The role of oxygen free radicals in the development of tissue injury and necrosis, including myocardial ischemic damage, is well documented. In this investigation, application of a free radical generator system (FRG) to rat myocardium resulted in ECG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ced92a2d69d9c84ed2943813ab00996
https://doi.org/10.1017/s0424820100128663
https://doi.org/10.1017/s0424820100128663