Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gary C. Pien"'
Autor:
Daniel J Hui, Shyrie C Edmonson, Gregory M Podsakoff, Gary C Pien, Lacramioara Ivanciu, Rodney M Camire, Hildegund Ertl, Federico Mingozzi, Katherine A High, Etiena Basner-Tschakarjan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
Adeno-associated virus (AAV) has become one of the most promising vectors in gene transfer in the last 10 years with successful translation to clinical trials in humans and even market approval for a first gene therapy product in Europe. Administrati
Externí odkaz:
https://doaj.org/article/c3c459a322e749a9b9b077cc70a13749
Autor:
Kerry S LeBenger, Cindy Barrett, Gary C Pien, Denise Scolpino, Jane M Simmons, Michele Difilippi, Danielle R Carotenuto, Robert W Brenner
Publikováno v:
Allergy and Asthma Proceedings. 31:507-510
Egg allergy is a contraindication for influenza vaccination because of the presence of trace egg protein. Although recent reports suggest that egg-allergic individuals can be safely immunized with seasonal influenza vaccine, the safety of H1N1 influe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d934d3fe8b9340222f8df07656aa6e9
https://doi.org/10.2500/aap.2010.31.3396
https://doi.org/10.2500/aap.2010.31.3396
Autor:
Shangzhen Zhou, Jonathan D. Finn, Katherine A. High, Harre D. Downey, Daniel Hui, Danielle Dunn, Gary C. Pien, Federico Mingozzi
Publikováno v:
Molecular Therapy. 18(1):135-142
Adeno-associated viral (AAV) vectors are an extensively studied and highly used vector platform for gene therapy applications. We hypothesize that in the first clinical trial using AAV to treat hemophilia B, AAV capsid proteins were presented on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ff358dc14fe6fe33f5c6cdd16cde19
Autor:
Federico Mingozzi, Daniel J. Hui, Hildegund C.J. Ertl, Shyrie C Edmonson, Rodney M. Camire, Etiena Basner-Tschakarjan, Lacramioara Ivanciu, Katherine A. High, Gregory M. Podsakoff, Gary C. Pien
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss, Pp-(2015)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Adeno-associated virus (AAV) has become one of the most promising vectors in gene transfer in the last 10 years with successful translation to clinical trials in humans and even market approval for a first gene therapy product in Europe. Administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd0ffba287b2b6e221a827ff93f4258
Autor:
Gary C. Pien, Akio Morinobu, Christine A. Biron, Wendy T. Watford, John J. O'Shea, Rachelle Salomon, Khuong B. Nguyen, Sigrun R. Hofmann, Massimo Gadina
Publikováno v:
Science. 297:2063-2066
Interferons (IFNs) are essential for host defense. Although the antiviral effects of the type 1 IFNs IFN-alpha and IFN-beta (IFN-alpha/beta) have been established, their immunoregulatory functions, especially their ability to regulate IFN-gamma produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6cd91246f08053a0a912293e53d18f
https://doi.org/10.1126/science.1074900
https://doi.org/10.1126/science.1074900
Autor:
Khuong B. Nguyen, Persephone Borrow, Arlene H. Sharpe, Christine A. Biron, Miriam Rodriguez Sosa, Ninghai Wang, Chengbin Wu, Matthew J. Edwards, Duncan Howie, Charles A. Gullo PhD, Cox Terhorst, Abhay R. Satoskar, Gary C. Pien
Publikováno v:
Nature Immunology. 2:410-414
SH2D1A, which encodes signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), is altered in patients with X-linked lymphoproliferative disease (XLP), a primary immunodeficiency. SAP-deficient mice infected with lymphocytic choriomen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161ed344aef0c2ebabeb7aa6e15b2e12
https://doi.org/10.1038/87713
https://doi.org/10.1038/87713
Autor:
Khuong B. Nguyen, Joan E. Durbin, Leslie P. Cousens, Christine A. Biron, Lesley Doughty, Gary C. Pien
Publikováno v:
Nature Immunology. 1:70-76
Induction of high systemic levels of type 1 interferons (IFNs) IFN-alpha and IFN-beta is a hallmark of many viral infections. In addition to their potent antiviral effects, these cytokines mediate a number of immunoregulatory functions and can promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::710bf131c4674629833ea5e36813a751
https://doi.org/10.1038/76940
https://doi.org/10.1038/76940
Autor:
Leslie P. Cousens, Christine A. Biron, Khuong B. Nguyen, Gary C. Pien, Thais P. Salazar-Mather
Publikováno v:
Annual Review of Immunology. 17:189-220
Natural killer (NK) cells are populations of lymphocytes that can be activated to mediate significant levels of cytotoxic activity and produce high levels of certain cytokines and chemokines. NK cells respond to and are important in defense against a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a2c2361323670126d11b89441f09b1
https://doi.org/10.1146/annurev.immunol.17.1.189
https://doi.org/10.1146/annurev.immunol.17.1.189
Autor:
Mustafa N. Yazicioglu, Leslie P. Cousens, Federico Mingozzi, Robert J. Davidson, Daniel J. Hui, Jonathan D. Finn, Virginia Haurigot, Gary C. Pien, Yifeng Chen, David W. Scott, Anne S. De Groot, Shangzhen Zhou, Etiena Basner-Tschakarjan, George Buchlis, Alex Tai
Publikováno v:
Molecular Therapy
Molecular Therapy, Cell Press, 2013, ⟨10.1038/mt.2013.166⟩
Molecular Therapy, 2013, ⟨10.1038/mt.2013.166⟩
Molecular Therapy, Cell Press, 2013, ⟨10.1038/mt.2013.166⟩
Molecular Therapy, 2013, ⟨10.1038/mt.2013.166⟩
International audience; Immune responses directed against viral capsid proteins constitute a main safety concern in the use of adeno-associated virus (AAV) as gene transfer vectors in humans. Pharmacological immunosuppression has been proposed as a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6342a62c7fb9a61f6f3145e291b5c77d
https://hal.archives-ouvertes.fr/hal-02881196
https://hal.archives-ouvertes.fr/hal-02881196
Autor:
Nicole C. Hasbrouck, Samuel J.H. Murphy, Jordan S. Orange, Federico Mingozzi, Gary C. Pien, Katherine A. High, Daniel J. Hui, Jonathan D. Finn, Etiena Basner-Tschakarjan, Shangzhen Zhou, Ashley N. Mentlik, Marcela V. Maus
Publikováno v:
The Journal of clinical investigation. 119(6)
Adeno-associated virus (AAV) vectors are effective gene delivery vehicles mediating long-lasting transgene expression. Data from a clinical trial of AAV2-mediated hepatic transfer of the Factor IX gene (F9) into hemophilia B subjects suggests that CT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c353f36e58151abf8ca34db1a42a38
https://pubmed.ncbi.nlm.nih.gov/19436115
https://pubmed.ncbi.nlm.nih.gov/19436115