Discovery of ADDL-Targeting Small Molecule Drugs for Alzheimers Disease

Autor: Raymond Lowe, Jean-Claude R. Breach, Todd Pray, Michele McEntee, Hsiu-Mei Wu, Catherine M. Hironaka, Lily Ruslim-Litrus, Sue Zhang, David Summa, Susan M. Catalano, Gary C. Look, Jasna Jerecic, Walter J. Crosier, Lev Igoudin, Diana B. Cherbavaz, William F. Goure, Grant A. Krafft

Publikováno v: Current Alzheimer Research. 4:562-567

Amyloid beta-derived diffusible ligands (ADDLs) comprise the neurotoxic subset of soluble Abeta(1-42) oligomers, now widely considered to be the molecular cause of memory malfunction and neurodegeneration in Alzheimer's disease (AD). We have develope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db0afa4f0f31c5abbedaaa031bf9029
https://doi.org/10.2174/156720507783018271

Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity

Autor: Ottavio Arancio, Gilbert M. Rishton, Alison Goate, Hank Safferstein, Jinbin Xu, Molly J. Kirk, Gary C. Look, Tara L. Spires-Jones, Robert H. Mach, Kelsie Mozzoni, Harry LeVine, Michael A. Cahill, Courtney Rehak, Colleen Silky, Chenbo Zeng, Elizabeth Head, Rolf J. Craven, Nicholas J. Izzo, Carlos Cruchaga, Susan M. Catalano, Raymond Yurko

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e111899 (2014)
Izzo, N J, Xu, J, Zeng, C, Kirk, M J, Mozzoni, K, Silky, C, Rehak, C, Yurko, R, Look, G, Rishton, G, Safferstein, H, Cruchaga, C, Goate, A, Cahill, M A, Arancio, O, Mach, R H, Craven, R, Head, E, Levine, H, Spires-jones, T L & Catalano, S M 2014, ' Alzheimer's Therapeutics Targeting Amyloid Beta 1-42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity ', PLoS ONE, vol. 9, no. 11, pp. e111899 . https://doi.org/10.1371/journal.pone.0111899
PloS one, vol 9, iss 11
PLoS ONE

Amyloid beta (Abeta) 1-42 oligomers accumulate in brains of patients with Mild Cognitive Impairment (MCI) and disrupt synaptic plasticity processes that underlie memory formation. Synaptic binding of Abeta oligomers to several putative receptor prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38b148dc95240bb264e216df6bedda7
http://europepmc.org/articles/PMC4229119?pdf=render

The identification of cyclooxygenase-1 inhibitors from 4-thiazolidinone combinatorial libraries

Autor: Gary C. Look, Christopher P. Holmes, Mark A. Gallop, Jason P. Chinn, John R. Schullek, Eric M. Gordon

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:707-712

Three 4-thiazolidinone libraries, each containing up to 540 compounds, were prepared and assayed for inhibition of the enzyme cyclooxygenase-1 (COX-1). Deconvolution analysis led to the identification of a compound that is equipotent with the commerc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7ba3de22bf5090c0852c33df03b9129
https://doi.org/10.1016/0960-894x(96)00097-2

Trimethylorthoformate: A mild and effective dehydrating reagent for solution and solid phase imine formation

Autor: Martin M. Murphy, Mark A. Gallop, Gary C. Look, David A. Campbell

Publikováno v: Tetrahedron Letters. 36:2937-2940

Trimethylorthoformate has been found to be an effective dehydrating solvent for the formation of imines, both in the solid phase as well as solution phase.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f005b9d49d9a958c8c97fd957ff7ba51
https://doi.org/10.1016/0040-4039(95)00442-f

Enzyme-catalyzed organic synthesis: practical routes to aza sugars and their analogs for use as glycoprocessing inhibitors

Autor: Gary C. Look, Chi-Huey Wong, Christopher H. Fotsch

Publikováno v: Accounts of Chemical Research. 26:182-190

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da2c5ed7474a258113b0078e8c5eea9f
https://doi.org/10.1021/ar00028a008