Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Gary C. Hon"'
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-6 (2024)
Abstract Undifferentiated pleomorphic sarcoma (UPS) and related tumors are the most common type of soft tissue sarcoma. However, this spectrum of tumors has different etiologies with varying rates of metastasis and survival. Two dermal-based neoplasm
Externí odkaz:
https://doaj.org/article/8e5780871a3c4ef2a2a8af13c6227cf8
Autor:
Yihan Wang, Gary C. Hon
Publikováno v:
Frontiers in Genome Editing, Vol 6 (2024)
Large scale cancer genomic studies in patients have unveiled millions of non-coding variants. While a handful have been shown to drive cancer development, the vast majority have unknown function. This review describes the challenges of functionally a
Externí odkaz:
https://doaj.org/article/88caf4ee4dc6452884a0c99147f6300a
Publikováno v:
JID Innovations, Vol 5, Iss 1, Pp 100322- (2025)
The UK Biobank includes genotype information for about 500,000 patients for over 7000 phenotypes. However, owing to multiple testing correction for approximately 200 billion tests, many clinically and statistically significant associations remain una
Externí odkaz:
https://doaj.org/article/2b513f55b76147a281e2c750a4b181ad
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102631- (2023)
Summary: A challenge in studying cervical epithelial cell biology at the single-cell level is that differentiated subtypes, in particular mucus-secreting goblet cells, are sensitive to disassociating enzymes making isolation of all epithelial subpopu
Externí odkaz:
https://doaj.org/article/e85d0dae22324ab99fb9e573c1d2f796
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Background Single-cell CRISPR screens are powerful tools to understand genome function by linking genetic perturbations to transcriptome-wide phenotypes. However, since few cells can be affordably sequenced in these screens, biased sampling
Externí odkaz:
https://doaj.org/article/397006fadd80408ea78a4a7d031b18b7
Autor:
Samadrita Bhattacharyya, Rahul K. Kollipara, Gabriela Orquera-Tornakian, Sean Goetsch, Minzhe Zhang, Cameron Perry, Boxun Li, John M. Shelton, Minoti Bhakta, Jialei Duan, Yang Xie, Guanghua Xiao, Bret M. Evers, Gary C. Hon, Ralf Kittler, Nikhil V. Munshi
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Comprehensive cis-regulatory landscapes are essential for accurate enhancer prediction and disease variant mapping. Although cis-regulatory element (CRE) resources exist for most tissues and organs, many rare — yet functionally important — cell t
Externí odkaz:
https://doaj.org/article/46dde78eea664fca9e8ce2e867c261c0
Autor:
Anne Cooley, ShanmugaPriyaa Madhukaran, Elizabeth Stroebele, Mariano Colon Caraballo, Lei Wang, Yucel Akgul, Gary C. Hon, Mala Mahendroo
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105953- (2023)
Summary: The cervical epithelium undergoes changes in proliferation, differentiation, and function that are critical to ensure fertility and maintain pregnancy. Here, we identify cervical epithelial subtypes in non-pregnant, pregnant, and in labor mi
Externí odkaz:
https://doaj.org/article/609d96e72e6e46dd9c0bbf17838065f9
Autor:
Boxun Li, Gary C. Hon
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
As we near a complete catalog of mammalian cell types, the capability to engineer specific cell types on demand would transform biomedical research and regenerative medicine. However, the current pace of discovering new cell types far outstrips our a
Externí odkaz:
https://doaj.org/article/e92a58334a3f437bb9b2918874b042aa
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2570-2578.e5 (2019)
Summary: Single-cell screens enable high-throughput functional assessment of enhancers in their endogenous genomic context. However, the design of current studies limits their application to identifying the primary gene targets of enhancers. Here, we
Externí odkaz:
https://doaj.org/article/e41940ede607471781cc79668953c0e7
Publikováno v:
Cell Reports, Vol 27, Iss 12, Pp 3486-3499.e6 (2019)
Summary: Ectopic expression of transcription factors (TFs) can reprogram cell state. However, because of the large combinatorial space of possible TF cocktails, it remains difficult to identify TFs that reprogram specific cell types. Here, we develop
Externí odkaz:
https://doaj.org/article/2805e13f0d1e46ccab417572d87d423c