Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Gary C. Chamness"'
Autor:
Rachel Schiff, Mothaffar F. Rimawi, C. Kent Osborne, Jenny C. Chang, Gary C. Chamness, Meghana V. Trivedi, Anne C. Pavlick, Sara Lopez-Tarruella, Joe W. Gray, Laura M. Heiser, Nicholas J. Wang, Carmine De Angelis, Susan G. Hilsenbeck, Tao Wang, Carolina Gutierrez, Alejandro Contreras, Sufeng Mao, Sabrina Herrera, Agostina Nardone, Xiaoyong Fu, Yen-Chao Wang, Huizhong Hu, Mario Giuliano
Supplementary Figure 2. ER expression changes upon neoadjuvant treatment with trastuzumab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b38ed6a099216efbf2e1288834c85f
https://doi.org/10.1158/1078-0432.22456521.v1
https://doi.org/10.1158/1078-0432.22456521.v1
Autor:
Rachel Schiff, Mothaffar F. Rimawi, C. Kent Osborne, Jenny C. Chang, Gary C. Chamness, Meghana V. Trivedi, Anne C. Pavlick, Sara Lopez-Tarruella, Joe W. Gray, Laura M. Heiser, Nicholas J. Wang, Carmine De Angelis, Susan G. Hilsenbeck, Tao Wang, Carolina Gutierrez, Alejandro Contreras, Sufeng Mao, Sabrina Herrera, Agostina Nardone, Xiaoyong Fu, Yen-Chao Wang, Huizhong Hu, Mario Giuliano
Purpose: To investigate the direct effect and therapeutic consequences of epidermal growth factor receptor 2 (HER2)-targeting therapy on expression of estrogen receptor (ER) and Bcl2 in preclinical models and clinical tumor samples.Experimental desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e0587fb0456056a2d9cbd81adb8b39
https://doi.org/10.1158/1078-0432.c.6523335
https://doi.org/10.1158/1078-0432.c.6523335
Autor:
Rachel Schiff, C. Kent Osborne, Jorge S. Reis-Filho, Britta Weigelt, Joe W. Gray, Mothaffar F. Rimawi, Susan G. Hilsenbeck, Chad A. Shaw, Ben H. Park, Gary C. Chamness, Felipe C. Geyer, Chandandeep Nagi, Carolina Gutierrez, Kenneth L. Scott, Daniel J. Zabransky, Ian Waters, Mahitha Rajendran, Tamika Mitchell, Martin Shea, Sarmistha Nanda, Tao Wang, Alexander Renwick, Edward S. Chen, Charlotte K.Y. Ng, Nicholas Wang, Laura M. Heiser, Vidyalakshmi Sethunath, Jamunarani Veeraraghavan, Lanfang Qin, Huizhong Hu, Agostina Nardone, Kathleen A. Burke, Carmine De Angelis, Xiaowei Xu
Purpose: Resistance to anti-HER2 therapies in HER2+ breast cancer can occur through activation of alternative survival pathways or reactivation of the HER signaling network. Here we employed BT474 parental and treatment-resistant cell line models to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e201b57c505d629e55aa1001b1f5bfb
https://doi.org/10.1158/1078-0432.c.6526164.v1
https://doi.org/10.1158/1078-0432.c.6526164.v1
Autor:
Rachel Schiff, C. Kent Osborne, Jorge S. Reis-Filho, Britta Weigelt, Joe W. Gray, Mothaffar F. Rimawi, Susan G. Hilsenbeck, Chad A. Shaw, Ben H. Park, Gary C. Chamness, Felipe C. Geyer, Chandandeep Nagi, Carolina Gutierrez, Kenneth L. Scott, Daniel J. Zabransky, Ian Waters, Mahitha Rajendran, Tamika Mitchell, Martin Shea, Sarmistha Nanda, Tao Wang, Alexander Renwick, Edward S. Chen, Charlotte K.Y. Ng, Nicholas Wang, Laura M. Heiser, Vidyalakshmi Sethunath, Jamunarani Veeraraghavan, Lanfang Qin, Huizhong Hu, Agostina Nardone, Kathleen A. Burke, Carmine De Angelis, Xiaowei Xu
Supplementary Figures S1-S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e427abe7531c4eca4121298b954c95
https://doi.org/10.1158/1078-0432.22465851.v1
https://doi.org/10.1158/1078-0432.22465851.v1
Autor:
Rachel Schiff, Mothaffar F. Rimawi, C. Kent Osborne, Jenny C. Chang, Gary C. Chamness, Meghana V. Trivedi, Anne C. Pavlick, Sara Lopez-Tarruella, Joe W. Gray, Laura M. Heiser, Nicholas J. Wang, Carmine De Angelis, Susan G. Hilsenbeck, Tao Wang, Carolina Gutierrez, Alejandro Contreras, Sufeng Mao, Sabrina Herrera, Agostina Nardone, Xiaoyong Fu, Yen-Chao Wang, Huizhong Hu, Mario Giuliano
Supplementary figure legend. Legend of supplementary Figure 1 and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da5960a0283b1e62e5e00f2e5913808
https://doi.org/10.1158/1078-0432.22456518
https://doi.org/10.1158/1078-0432.22456518
Autor:
Rachel Schiff, C. Kent Osborne, Jorge S. Reis-Filho, Britta Weigelt, Joe W. Gray, Mothaffar F. Rimawi, Susan G. Hilsenbeck, Chad A. Shaw, Ben H. Park, Gary C. Chamness, Felipe C. Geyer, Chandandeep Nagi, Carolina Gutierrez, Kenneth L. Scott, Daniel J. Zabransky, Ian Waters, Mahitha Rajendran, Tamika Mitchell, Martin Shea, Sarmistha Nanda, Tao Wang, Alexander Renwick, Edward S. Chen, Charlotte K.Y. Ng, Nicholas Wang, Laura M. Heiser, Vidyalakshmi Sethunath, Jamunarani Veeraraghavan, Lanfang Qin, Huizhong Hu, Agostina Nardone, Kathleen A. Burke, Carmine De Angelis, Xiaowei Xu
supplementary methods and figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e0d9ee9ce58c4edf0a351323100c28
https://doi.org/10.1158/1078-0432.22465845
https://doi.org/10.1158/1078-0432.22465845
Autor:
Rachel Schiff, Mothaffar F. Rimawi, C. Kent Osborne, Jenny C. Chang, Gary C. Chamness, Meghana V. Trivedi, Anne C. Pavlick, Sara Lopez-Tarruella, Joe W. Gray, Laura M. Heiser, Nicholas J. Wang, Carmine De Angelis, Susan G. Hilsenbeck, Tao Wang, Carolina Gutierrez, Alejandro Contreras, Sufeng Mao, Sabrina Herrera, Agostina Nardone, Xiaoyong Fu, Yen-Chao Wang, Huizhong Hu, Mario Giuliano
Supplementary Figure 1. Lapatinib clinical trial scheme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33eb2333bc0e525e83aef791fdcc11d3
https://doi.org/10.1158/1078-0432.22456524
https://doi.org/10.1158/1078-0432.22456524
Autor:
Rachel Schiff, C. Kent Osborne, Jorge S. Reis-Filho, Britta Weigelt, Joe W. Gray, Mothaffar F. Rimawi, Susan G. Hilsenbeck, Chad A. Shaw, Ben H. Park, Gary C. Chamness, Felipe C. Geyer, Chandandeep Nagi, Carolina Gutierrez, Kenneth L. Scott, Daniel J. Zabransky, Ian Waters, Mahitha Rajendran, Tamika Mitchell, Martin Shea, Sarmistha Nanda, Tao Wang, Alexander Renwick, Edward S. Chen, Charlotte K.Y. Ng, Nicholas Wang, Laura M. Heiser, Vidyalakshmi Sethunath, Jamunarani Veeraraghavan, Lanfang Qin, Huizhong Hu, Agostina Nardone, Kathleen A. Burke, Carmine De Angelis, Xiaowei Xu
Supplementary tables S1-S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d6915877b2311caa8e686d7fc8a0c8
https://doi.org/10.1158/1078-0432.22465848
https://doi.org/10.1158/1078-0432.22465848
Autor:
Jorge S. Reis-Filho, Nikhil Wagle, Ofir Cohen, Sepideh Mehravaran, Jamunarani Veeraraghavan, Resel Pereira, Myles Brown, Lanfang Qin, Bert W. O'Malley, Carmine De Angelis, Carolina Gutierrez, Vidyalakshmi Sethunath, Xiaoyong Fu, Rachel Schiff, Maria Letizia Cataldo, Sarmistha Nanda, Qin Feng, Mothaffar F. Rimawi, Gary C. Chamness, Rinath Jeselsohn, Britta Weigelt, Pier Selenica, Agostina Nardone, C. Kent Osborne
Publikováno v:
Proc Natl Acad Sci U S A
Forkhead box A1 (FOXA1) is a pioneer factor that facilitates chromatin binding and function of lineage-specific and oncogenic transcription factors. Hyperactive FOXA1 signaling due to gene amplification or overexpression has been reported in estrogen
Autor:
Xiaoyong Fu, Shixia Huang, Resel Pereira, Nicholas J. Wang, Chad A. Shaw, Jorge S. Reis-Filho, Sarmistha Nanda, Anna Tsimelzon, Agostina Nardone, Vidyalakshmi Sethunath, Rachel Schiff, Laura M. Heiser, Britta Weigelt, Lukas M. Simon, Joe W. Gray, Carmine De Angelis, Tao Wang, Mothaffar F. Rimawi, Lanfang Qin, Gary C. Chamness, Obi L. Griffith, Jamunarani Veeraraghavan, Huizhong Hu, C. Kent Osborne, Susan G. Hilsenbeck
Publikováno v:
Mol Cancer Res
Mol. Cancer Res. 17, 2318-2330 (2019)
Mol. Cancer Res. 17, 2318-2330 (2019)
Despite effective strategies, resistance in HER2+ breast cancer remains a challenge. While the mevalonate pathway (MVA) is suggested to promote cell growth and survival, including in HER2+ models, its potential role in resistance to HER2-targeted the