Interaction between apolipoprotein E genotype and hypertension on cognitive function in older women in the Nurses' Health Study.

Autor: Iris Y Kim, Francine Grodstein, Peter Kraft, Gary C Curhan, Katherine C Hughes, Hongyan Huang, Jae H Kang, David J Hunter

Publikováno v: PLoS ONE, Vol 14, Iss 11, p e0224975 (2019)

ObjectiveTo examine the interaction between APOE genotypes and both treated and untreated hypertension on cognitive function in an updated analysis of Nurses' Health Study (NHS) data.DesignAt baseline (1995-2001) and 3 biennial follow-up assessments

Externí odkaz: https://doaj.org/article/ecead8ef7a114527a6472338ee269050

Herpes zoster and long-term risk of subjective cognitive decline

Autor: Tian-Shin Yeh, Gary C. Curhan, Barbara P. Yawn, Walter C. Willett, Sharon G. Curhan

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)

Abstract Background Herpes zoster (HZ), commonly known as “shingles,” may contribute to cognitive decline through mechanisms such as neuroinflammation or direct neuronal injury. However, evidence on the longitudinal association between HZ and cog

Externí odkaz: https://doaj.org/article/b8d2ee581ca141bf8bb96a08918d6677

Genome-wide association and functional follow-up reveals new loci for kidney function.

Autor: Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A Böger, Christian Fuchsberger, Matthias Olden, Ming-Huei Chen, Adrienne Tin, Daniel Taliun, Man Li, Xiaoyi Gao, Mathias Gorski, Qiong Yang, Claudia Hundertmark, Meredith C Foster, Conall M O'Seaghdha, Nicole Glazer, Aaron Isaacs, Ching-Ti Liu, Albert V Smith, Jeffrey R O'Connell, Maksim Struchalin, Toshiko Tanaka, Guo Li, Andrew D Johnson, Hinco J Gierman, Mary Feitosa, Shih-Jen Hwang, Elizabeth J Atkinson, Kurt Lohman, Marilyn C Cornelis, Åsa Johansson, Anke Tönjes, Abbas Dehghan, Vincent Chouraki, Elizabeth G Holliday, Rossella Sorice, Zoltan Kutalik, Terho Lehtimäki, Tõnu Esko, Harshal Deshmukh, Sheila Ulivi, Audrey Y Chu, Federico Murgia, Stella Trompet, Medea Imboden, Barbara Kollerits, Giorgio Pistis, CARDIoGRAM Consortium, ICBP Consortium, CARe Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), Tamara B Harris, Lenore J Launer, Thor Aspelund, Gudny Eiriksdottir, Braxton D Mitchell, Eric Boerwinkle, Helena Schmidt, Margherita Cavalieri, Madhumathi Rao, Frank B Hu, Ayse Demirkan, Ben A Oostra, Mariza de Andrade, Stephen T Turner, Jingzhong Ding, Jeanette S Andrews, Barry I Freedman, Wolfgang Koenig, Thomas Illig, Angela Döring, H-Erich Wichmann, Ivana Kolcic, Tatijana Zemunik, Mladen Boban, Cosetta Minelli, Heather E Wheeler, Wilmar Igl, Ghazal Zaboli, Sarah H Wild, Alan F Wright, Harry Campbell, David Ellinghaus, Ute Nöthlings, Gunnar Jacobs, Reiner Biffar, Karlhans Endlich, Florian Ernst, Georg Homuth, Heyo K Kroemer, Matthias Nauck, Sylvia Stracke, Uwe Völker, Henry Völzke, Peter Kovacs, Michael Stumvoll, Reedik Mägi, Albert Hofman, Andre G Uitterlinden, Fernando Rivadeneira, Yurii S Aulchenko, Ozren Polasek, Nick Hastie, Veronique Vitart, Catherine Helmer, Jie Jin Wang, Daniela Ruggiero, Sven Bergmann, Mika Kähönen, Jorma Viikari, Tiit Nikopensius, Michael Province, Shamika Ketkar, Helen Colhoun, Alex Doney, Antonietta Robino, Franco Giulianini, Bernhard K Krämer, Laura Portas, Ian Ford, Brendan M Buckley, Martin Adam, Gian-Andri Thun, Bernhard Paulweber, Margot Haun, Cinzia Sala, Marie Metzger, Paul Mitchell, Marina Ciullo, Stuart K Kim, Peter Vollenweider, Olli Raitakari, Andres Metspalu, Colin Palmer, Paolo Gasparini, Mario Pirastu, J Wouter Jukema, Nicole M Probst-Hensch, Florian Kronenberg, Daniela Toniolo, Vilmundur Gudnason, Alan R Shuldiner, Josef Coresh, Reinhold Schmidt, Luigi Ferrucci, David S Siscovick, Cornelia M van Duijn, Ingrid Borecki, Sharon L R Kardia, Yongmei Liu, Gary C Curhan, Igor Rudan, Ulf Gyllensten, James F Wilson, Andre Franke, Peter P Pramstaller, Rainer Rettig, Inga Prokopenko, Jacqueline C M Witteman, Caroline Hayward, Paul Ridker, Afshin Parsa, Murielle Bochud, Iris M Heid, Wolfram Goessling, Daniel I Chasman, W H Linda Kao, Caroline S Fox

Publikováno v: PLoS Genetics, Vol 8, Iss 3, p e1002584 (2012)

Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6

Externí odkaz: https://doaj.org/article/14344aa218b0488aac7fd77f4ecb7d22

Prediction of 24‐Hour Urinary Sodium Excretion Using Machine‐Learning Algorithms

Autor: Rikuta Hamaya, Molin Wang, Stephen P. Juraschek, Kenneth J. Mukamal, JoAnn E. Manson, Deirdre K. Tobias, Qi Sun, Gary C. Curhan, Walter C. Willett, Eric B. Rimm, Nancy R. Cook

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 10 (2024)

Background Accurate quantification of sodium intake based on self‐reported dietary assessments has been a persistent challenge. We aimed to apply machine‐learning (ML) algorithms to predict 24‐hour urinary sodium excretion from self‐reported

Externí odkaz: https://doaj.org/article/4df7ef3de8714067a189dcfd676078bd

Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH

Autor: Benjamin K. Canales, Jennifer A. Smith, I. David Weiner, Erin B. Ware, Wei Zhao, Sharon L.R. Kardia, Gary C. Curhan, Stephen T. Turner, MD, Majuran Perinpam, BS, John C. Lieske

Publikováno v: Kidney International Reports, Vol 2, Iss 6, Pp 1111-1121 (2017)

Urine pH is critical for net acid and solute excretion, but the genetic factors that contribute to its regulation are incompletely understood. Methods: We tested the association of single nucleotide polymorphisms (SNPs) from 16 genes related to ammon

Externí odkaz: https://doaj.org/article/71632f0bc9bd4a228bdcb8f0f3e46b9a