Výsledky vyhledávání - "Gary Bruce Lipton"

A computational model for classification of BRCA2 variants using mouse embryonic stem cell-based functional assays

Autor: Linda Cleveland, Stacey Stauffer, Gary Bruce Lipton, Teresa Sullivan, Valentin Magidson, Eileen Southon, Susan W. Reid, Kajal Biswas, Edwin S. Iversen, Shyam K. Sharan

Publikováno v: npj Genomic Medicine, Vol 5, Iss 1, Pp 1-16 (2020)
NPJ Genomic Medicine

Sequencing-based genetic tests to identify individuals at increased risk of hereditary breast and ovarian cancers have resulted in the identification of more than 40,000 sequence variants of BRCA1 and BRCA2. A majority of these variants are considere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8e208c586954cd5937789c45ec6d08
https://doaj.org/article/040ac1e333f54a36a947eae448e108dd

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Bridging the gaps: using an NHP model to predict single dose radiation absorption in humans

Autor: Edwin S. Iversen, Janice M. McCarthy, Holly K. Dressman, Joel R. Ross, Nelson J. Chao, Kirsten Bell Burdett, Gary Phillips, Gary Bruce Lipton

Publikováno v: International Journal of Radiation Biology. 96:47-56

Purpose: Design and characterization of a radiation biodosimetry device are complicated by the fact that the requisite data are not available in the intended use population, namely humans e...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2826e4416f8ad4fee48139a6110966ed
https://doi.org/10.1080/09553002.2018.1532614

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Assessment of the Clinical Relevance of BRCA2 Missense Variants by Functional and Computational Approaches

Autor: Rachel Karchin, Vernon S. Pankratz, Namit Singh, Gary Bruce Lipton, Hermela Shimelis, David E. Goldgar, Fergus J. Couch, Edwin S. Iversen, Noralane M. Lindor, David L. Masica, Lucia Guidugli, Chunling Hu, Alvaro N.A. Monteiro

Publikováno v: The American Journal of Human Genetics. 102:233-248

Many variants of uncertain significance (VUS) have been identified in BRCA2 through clinical genetic testing. VUS pose a significant clinical challenge because the contribution of these variants to cancer risk has not been determined. We conducted a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220e7cd1d2ea67a01e5d78d5aab01008
https://doi.org/10.1016/j.ajhg.2017.12.013

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Abstract GS4-06: Cancer risks and response to targeted therapy associated with BRCA2 variants of uncertain significance

Autor: Fergus J. Couch, Hermela Shimelis, Raymond Moore, Steven N. Hart, Edwin S. Iversen, Abigail Thomas, Gary Bruce Lipton

Publikováno v: Cancer Research. 78:GS4-06

Background: Germline genetic testing of individuals with a diagnosis of triple negative breast cancer, young age at diagnosis, or a family history of breast and/or ovarian cancer has led to the identification of many unique BRCA2 missense variants of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7991a8118c2658745f7ccdacd3a9640
https://doi.org/10.1158/1538-7445.sabcs17-gs4-06

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Abstract 3507: Race-related genetic variation and response to secondary hormonal therapy in metastatic castration-resistant prostate cancer

Autor: Tyler A. Allen, Kouros Owzar, Alexander B. Sibley, Jennifer A. Freedman, Steven R. Patierno, Patrick Healy, Bonnie LaCroix, Brendon M. Patierno, Terry Hyslop, Gary Bruce Lipton, Daniel J. George

Publikováno v: Cancer Research. 80:3507-3507

Prostate cancer (PCa) is the second most common cancer diagnosed in men globally, after lung cancer. PCa incidence, aggressiveness and mortality are significantly higher among African Americans (AAs) compared with men of other racial/ethnic groups. D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61e3a1b0b07d141ed16a6a225075b69c
https://doi.org/10.1158/1538-7445.am2020-3507

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Functional Annotation Signatures of Disease Susceptibility Loci Improve SNP Association Analysis

Autor: Alvaro N.A. Monteiro, Merlise A. Clyde, Gary Bruce Lipton, Edwin S. Iversen

Publikováno v: BMC Genomics

Background Genetic association studies are conducted to discover genetic loci that contribute to an inherited trait, identify the variants behind these associations and ascertain their functional role in determining the phenotype. To date, functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515839333e96806f4150885d1ee288e6
https://doi.org/10.1101/000158

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Abstract 4685: Characterization of variants of uncertain significance (VUS) in breast and ovarian cancer predisposition genes

Autor: Hermela Shimelis, Emily Hallberg, Edwin S. Iversen, Chunling Hu, Gary Bruce Lipton, Fergus J. Couch, Noralane M. Lindor, Andreas S. Schroeder

Publikováno v: Cancer Research. 75:4685-4685

Panel-based germline genetic testing of established breast and ovarian cancer predisposition genes is widely used in high-risk clinics to inform on risks of breast and ovarian cancer. While most protein truncating mutations identified in predispositi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5200d38de5de2d27a55ec03494ab5214
https://doi.org/10.1158/1538-7445.am2015-4685

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Automaticity, axion invisibility and cosnological baryosynthesis

Autor: Gary Bruce Lipton, Paul H. Frampton

Publikováno v: Nuclear Physics B. 219:41-60

We explore the reconciliation between solution of the strong CP problem by the invisible axion technique and the successful qualitative explanation of the baryon number of the universe from grand unification. Imposition of Peccei-Quinn symmetry can m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d33523e0ec2b16763e0903117b4e7a1a
https://doi.org/10.1016/0550-3213(83)90427-3

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