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Novel Non-Cyclooxygenase Inhibitory Derivative of Sulindac Inhibits Breast Cancer Cell Growth In Vitro and Reduces Mammary Tumorigenesis in Rats.

Autor: Tinsley HN; Department of Biology Chemistry, Mathematics, and Computer Science, University of Montevallo, Montevallo, AL 35115, USA., Mathew B; Drug Discovery Division, Southern Research, Birmingham, AL 35205, USA., Chen X; Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA., Maxuitenko YY; Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA., Li N; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35205, USA., Lowe WM; Department of Biology Chemistry, Mathematics, and Computer Science, University of Montevallo, Montevallo, AL 35115, USA., Whitt JD; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35205, USA., Zhang W; Drug Discovery Division, Southern Research, Birmingham, AL 35205, USA., Gary BD; Drug Discovery Division, Southern Research, Birmingham, AL 35205, USA., Keeton AB; Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA., Grizzle WE; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35205, USA.; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35205, USA., Grubbs CJ; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35205, USA., Reynolds RC; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35205, USA., Piazza GA; Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, AL 36849, USA.

Publikováno v: Cancers [Cancers (Basel)] 2023 Jan 20; Vol. 15 (3). Date of Electronic Publication: 2023 Jan 20.

Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors.

Autor: Abdel-Rahman HM; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Abdel-Aziz M; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt., Tinsley HN; Department of Biology, Chemistry and Mathematics, University of Montevallo, Montevallo, AL, USA., Gary BD; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Canzoneri JC; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Piazza GA; Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2016 Feb; Vol. 349 (2), pp. 104-11. Date of Electronic Publication: 2015 Dec 20.

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.

Autor: Li N; Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, AL, USA., Lee K; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Xi Y; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Zhu B; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Gary BD; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Ramírez-Alcántara V; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Gurpinar E; Department of Pharmacology and Toxicology, The University of Alabama at Birmingham, Birmingham, AL, USA., Canzoneri JC; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Fajardo A; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Sigler S; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Piazza JT; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Chen X; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Andrews J; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Thomas M; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Lu W; Drug Discovery Division, Southern Research Institute, Birmingham, AL, USA., Li Y; Drug Discovery Division, Southern Research Institute, Birmingham, AL, USA., Laan DJ; School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA., Moyer MP; INCELL Corporation LLC, San Antonio, TX, USA., Russo S; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Eberhardt BT; Department of Chemistry, University of South Alabama, Mobile, AL, USA., Yet L; Department of Chemistry, University of South Alabama, Mobile, AL, USA., Keeton AB; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Grizzle WE; Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA., Piazza GA; Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.

Publikováno v: Oncogene [Oncogene] 2015 Mar 19; Vol. 34 (12), pp. 1499-509. Date of Electronic Publication: 2014 Apr 07.

Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention.

Autor: Aboul-Fadl T; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia., Al-Hamad SS; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia., Lee K; Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA., Li N; Department of Biochemistry, The University of Alabama at Birmingham, Birmingham, AL 35205, USA., Gary BD; Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA., Keeton AB; Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA., Piazza GA; Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA., Abdel-Hamid MK; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Publikováno v: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents [Med Chem Res] 2014 Sep; Vol. 23 (9), pp. 4177-4188.