Výsledky vyhledávání - "Gary B. Henderson"

Identification of efflux systems for large anions and anionic conjugates as the mediators of methotrexate efflux in L1210 cells

Autor: Manju Saxena, Gary B. Henderson

Publikováno v: Biochemical Pharmacology. 51:975-982

Two ATP-dependent efflux systems for methotrexate have been identified in inside-out vesicles from an L1210 mouse cell variant with a defective influx carrier for methotrexate. Transport at 40 muM [3H]methotrexate was separated by inhibitors into two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2943ad673af64a1bbca2de22f96a75a9
https://doi.org/10.1016/0006-2952(96)00051-2

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Suramin sodium: Pronounced effects on methotrexate transport and anti-folate activity in cultured tumor cells

Autor: Andres Bustamante, Rena Patel, Darryl Rideout, Gary B. Henderson

Publikováno v: International Journal of Cancer. 61:840-847

Suramin is an experimental anti-neoplastic agent which has shown promising activity against prostatic carcinoma and lymphoma in clinical trials. To elucidate its mechanism of action, suramin was examined for an effect on the transport of folate compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00232046ed57f4ffec1069aca7652a71
https://doi.org/10.1002/ijc.2910610616

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ATP-dependent Efflux of 2,4-Dinitrophenyl-S-glutathione

Autor: Manju Saxena, Gary B. Henderson

Publikováno v: Journal of Biological Chemistry. 270:5312-5319

The transport of 2,4-dinitrophenyl-S-glutathione (DNP-SG) into inside-out vesicles from L1210 cells was employed to identify and characterize ATP-dependent efflux routes for DNP-SG. Measurements of ATP-dependent uptake at varying concentrations of [3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a50d1d0391d7c07c47c7ff9ea0267fe
https://doi.org/10.1074/jbc.270.10.5312

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5′-Cholesteryl-phosphorothioate oligodeoxynucleotides: potent inhibition of methotrexate transport and antagonism of methotrexate toxicity in cells containing the reduced-folate carrier

Autor: Gary B. Henderson, C. A. Stein

Publikováno v: Nucleic Acids Research. 23:3726-3731

Polyanionic 5'-cholesteryl-phosphorothioate oligodeoxynucleotides of varying polymer length and nucleobase composition were examined for an effect on methotrexate transport via the reduced-folate carrier of L1210 mouse cells. Methotrexate transport w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1d20aadc43276d9b08aeb8fa7190bf
https://doi.org/10.1093/nar/23.18.3726

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Functional implications from the effects of 1-chloro-2,4-dinitrobenzene and ethacrynic acid on efflux routes for methotrexate and cholate in L1210 cells

Autor: Gary B. Henderson, Manju Saxena, T R Hughes

Publikováno v: Journal of Biological Chemistry. 269:13382-13389

1-Chloro-2,4-dinitrobenzene (CDNB) and ethacrynic acid were examined for the ability to inhibit unidirectional efflux routes in L1210 cells that extrude both methotrexate and cholate (system I) and methotrexate alone (system II). These electrophiles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93620f3252772e639c65b39e27c094ae
https://doi.org/10.1016/s0021-9258(17)36844-8

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Separation and inhibitor specificity of a second unidirectional efflux route for methotrexate in L1210 cells

Autor: Gary B. Henderson

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1110:137-143

L1210 cells mediate the unidirectional and energy-dependent efflux of methotrexate. Efflux occurs primarily via a system which has a high sensitivity to prostaglandin A 1 , vincristine, reserpine, verapamil, and bromosulfophthalein, but evidence has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1b3a7eba3d5a5249b8dd65b0780c91
https://doi.org/10.1016/0005-2736(92)90350-u

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Folate-Binding Proteins

Autor: Gary B. Henderson

Publikováno v: Annual Review of Nutrition. 10:319-335

Folate-binding proteins of three major classes have been observed in various bodily fluids and in the plasma membrane and cytoplasm of normal and neoplastic cells. A major class, the high-affinity folate-binding proteins, show a preferential and tigh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c192add64715a35f8ebd0bd35616ac1
https://doi.org/10.1146/annurev.nu.10.070190.001535

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Growth inhibition by homofolate in tumor cells utilizing a high-affinity folate binding protein as a means for folate internalization

Autor: Brian P. Strauss, Gary B. Henderson

Publikováno v: Biochemical Pharmacology. 39:2019-2025

A subline (JT-1) of L1210 mouse leukemia cells that contains elevated levels of a high-affinity folate binding protein is sensitive to growth inhibition by homofolate. Inhibition was observed at nanomolar concentrations of folate or 5-fonnyltetrahydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f047ad30a33b6e999af9bfb9c86207
https://doi.org/10.1016/0006-2952(90)90624-t

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Identification of cholate as a shared substrate for the unidirectional efflux systems for methotrexate in L1210 mouse cells

Autor: Judy M. Tsuji, Gary B. Henderson

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1051:60-70

The bidirectional transport properties of cholate have been examined in leukemic L1210 mouse cells and compared with the transport of methotrexate. The cell entry of [3H]cholate was Na(+)-independent, linear with increasing concentrations of substrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135a95f2d9630333cf8f22e081dcecdb
https://doi.org/10.1016/0167-4889(90)90174-c

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