Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gary Asmussen"'
Autor:
John L. Kane, Junkai Liao, Kevin D. Noson, Gary Asmussen, Yibin Xiang, Maria Fitzgerald, Christine Klaus, Bradford H. Hirth, Michael Booker, Christopher Yee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4550-4554
Building on our initial work, we have identified additional novel inhibitors of sphingosine kinase-1 (SK1). These new analogs address the shortcomings found in our previously reported compounds. Inhibitors 51 and 54 demonstrated oral bioavailability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369c9d41ca3e07b0818f4eabf2709c0f
https://doi.org/10.1016/j.bmcl.2010.06.019
https://doi.org/10.1016/j.bmcl.2010.06.019
Autor:
Gary Asmussen, Yibin Xiang, John L. Kane, Bradford H. Hirth, Christopher Yee, Kevin D. Noson, Michael Booker, Junkai Liao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6119-6121
Sphingosine kinase 1 (SK1) is an important enzyme that regulates the balance between ceramide and sphingosine-1-phosphate (S1P). Potent and novel SK1 inhibitors (6ag, 9ab and 12aa) have been discovered through a series of modifications of sphingosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a347c182cf62373121f9b662ce5ea70
https://doi.org/10.1016/j.bmcl.2009.09.022
https://doi.org/10.1016/j.bmcl.2009.09.022
Autor:
Tatiana Gladysheva, Yibin Xiang, A.C Good, Bradford H. Hirth, T Fremgen, Gary Asmussen, Renato Skerlj, A Jain, Kimberly Bishop, J.D Stepp, Ronnie Wei, Katherine Jancsics, Maria Fitzgerald, Jinyu Liu, H.P Biemann, Markus Metz, Andrew T Papoulis
Publikováno v:
Journal of medicinal chemistry. 55(6)
We have studied the subtleties of fragment docking and binding using data generated in a Pim-1 kinase inhibitor program. Crystallographic and docking data analyses have been undertaken using inhibitor complexes derived from an in-house surface plasmo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35c78468ba65305e73f208d0e42ebe7
https://pubmed.ncbi.nlm.nih.gov/22339127
https://pubmed.ncbi.nlm.nih.gov/22339127
Autor:
Yibin Xiang, Hans-Peter Biemann, Tatiana Gladysheva, Markus Metz, J. David Stepp, Renato Skerlj, Andrew T Papoulis, Andrew C. Good, Kimberly Bishop, Annuradha Jain, Gary Asmussen, Bradford H. Hirth, Katherine Jancsics, Maria Fitzgerald, Ronnie Wei, Jinyu Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(10)
Novel benzofuran-2-carboxylic acids, exemplified by 29, 38 and 39, have been discovered as potent Pim-1 inhibitors using fragment based screening followed by X-ray structure guided medicinal chemistry optimization. The compounds demonstrate potent in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f2a70806999950d2d3da86a2785090
https://pubmed.ncbi.nlm.nih.gov/21507633
https://pubmed.ncbi.nlm.nih.gov/21507633
Autor:
Gary Asmussen, Lindsay D Spence
Publikováno v:
Forensic science international. 132(2)
The results presented demonstrate the capacity for spectral enhancement to substantially improve the forensic examination of footwear impressions in blood treated with leucocrystal violet (LCV). The UV-Vis absorption spectra were generated of (i) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9622fb1d46c9b288fccee7418e575cd
https://pubmed.ncbi.nlm.nih.gov/12711191
https://pubmed.ncbi.nlm.nih.gov/12711191
Autor:
David J. Stepp, Trish Fremgen, Ronnie Wei, Hans-Peter N. Bieman, Markus Metz, Maria Fitzgerald, Renato Skerlj, Bradforth H. Hirth, Yibin Xiang, Michael Kothe, Gary Asmussen, Andrew T Papoulis, Jinyu Liu, Katherine Jancsics
Publikováno v:
Cancer Research. 71:2790-2790
Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. Recently, Pim-1 has been implicated in multiple human cancers, including prostate cancer, acute myeloid leukemia and other hematopoietic malignancies. Primarily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cba0c0a53264004830e8398c7e4309e
https://doi.org/10.1158/1538-7445.am2011-2790
https://doi.org/10.1158/1538-7445.am2011-2790