Effects of rIL2/anti-IL2 antibody complex on chikungunya virus-induced chronic arthritis in a mouse model

Autor: Sarah R. Tritsch, Abigail J. Porzucek, Arnold M. Schwartz, Abigale M. Proctor, Richard L. Amdur, Patricia S. Latham, Gary L. Simon, Christopher N. Mores, Aileen Y. Chang

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Chikungunya virus (CHIKV) is characterized by disabling joint pain that can cause persistent arthritis in approximately one-fourth of patients. Currently, no standard treatments are available for chronic CHIKV arthritis. Our preliminary data

Externí odkaz: https://doaj.org/article/5234ad6cd63345829163e63510e1158d

Use of BioFire FilmArray gastrointestinal PCR panel associated with reductions in antibiotic use, time to optimal antibiotics, and length of stay

Autor: Daisy Torres-Miranda, Hana Akselrod, Ryan Karsner, Alessandra Secco, Diana Silva-Cantillo, Marc O. Siegel, Afsoon D. Roberts, Gary L. Simon

Publikováno v: BMC Gastroenterology, Vol 20, Iss 1, Pp 1-7 (2020)

Abstract Background Rapid and accurate diagnostic tools are needed for appropriate management of infectious diarrhea. Methods We evaluated the impact of the introduction of rapid multiplex PCR testing using the FilmArray gastrointestinal (GI) panel (

Externí odkaz: https://doaj.org/article/11e7ae65b506466c914aa99da6fc736a

An individual with human immunodeficiency virus, dementia, and central nervous system amyloid deposition

Autor: Raymond Scott Turner, Melanie Chadwick, Wesley A. Horton, Gary L. Simon, Xiong Jiang, Giuseppe Esposito

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 4, Iss 1, Pp 1-5 (2016)

Abstract Human immunodeficiency virus (HIV)–associated neurocognitive disorder (HAND) is found in 30%–50% of individuals with HIV infection. To date, no HIV+ individual has been reported to have a positive amyloid PET scan. We report a 71‐year�

Externí odkaz: https://doaj.org/article/bc10b14ba0654b3baeec155206187ae1

Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis

Autor: Aileen Y. Chang, Felipe Gomes Naveca, Maony Rodrigues-Moreno, Hugh Watson, Gary L. Simon, Gary S. Firestein, Ramão Luciano Nogueira-Hayd, Karol Suchowiecki, Giulia Calusi

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Watson, H, Nogueira-Hayd, R L, Rodrigues-Moreno, M, Naveca, F, Calusi, G, Suchowiecki, K, Firestein, G S, Simon, G & Chang, A Y 2021, ' Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis ', Scientific Reports, vol. 11, no. 1, 18578 . https://doi.org/10.1038/s41598-021-98164-9
Scientific Reports

Chronic rheumatological manifestations similar to those of rheumatoid arthritis (RA) are described after chikungunya virus infection. We aimed to compare the relevance of joint counts and symptoms to clinical outcomes in RA and chronic chikungunya di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df788a58bb257b24d6761fe33e31db9
https://doaj.org/article/d3967d5fca6a4114a272fe872fccbc9f

Metataxonomic and Metagenomic Approaches Versus Culture-Based Techniques For Clinical Pathology

Autor: Sarah K Hilton, Eduardo eCastro Nallar, Marcos ePérez-Losada, Ian eToma, Timothy A McCaffrey, Eric P. Hoffman, Marc O. Siegel, Gary L. Simon, W. Evan Johnson, Keith A Crandall

Publikováno v: Frontiers in Microbiology, Vol 7 (2016)

Diagnoses that are both timely and accurate are critically important for patients with life-threatening or drug resistant infections. Technological improvements in High-Throughput Sequencing (HTS) have led to its use in pathogen detection and its app

Externí odkaz: https://doaj.org/article/e166d1f30e5a42c3ac2d38dfc30db835