Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Gary A. Sega"'
Autor:
Gary A. Sega, Cymbeline T. Culiat, Eugene M. Rinchik, Loren Hauser, Catherine M. Withrow, Dabney K. Johnson, Jennifer L. Aponte, Madhu S Dhar, Donald A. Carpenter
Publikováno v:
Proceedings of the National Academy of Sciences. 98:641-645
Hereditary tyrosinemia type 1 (HT1) is a severe autosomal recessive metabolic disease associated with point mutations in the human fumarylacetoacetate hydrolase ( FAH ) gene that disrupt tyrosine catabolism. An acute form of HT1 results in death duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714dfc75be86a79741b750a9a04e7780
https://doi.org/10.1073/pnas.98.2.641
https://doi.org/10.1073/pnas.98.2.641
Autor:
Gary A. Sega, Rene E. Sotomayor
Publikováno v:
Environmental and Molecular Mutagenesis. 36:255-265
The unscheduled DNA synthesis (UDS) assay measures DNA repair in response to DNA damage. To date, 59 chemicals plus UV and X rays have been tested for UDS in spermatogenic cells of humans, rabbits, rats, and mice. In vivo, in vitro, and combined in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e25e611352291b06c206cbc1b3d91a0d
https://doi.org/10.1002/1098-2280(2000)36:4<255::aid-em1>3.0.co
https://doi.org/10.1002/1098-2280(2000)36:4<255::aid-em1>3.0.co
Publikováno v:
Teratogenesis, Carcinogenesis, and Mutagenesis. 19:339-351
An autoradiographic procedure was used to measure unscheduled DNA synthesis (UDS, DNA repair synthesis) in spermatogonial and postspermatogonial cell stages of mice after treatment with two doses of N-ethyl-N-nitrosourea (ENU) and N-methyl-N-nitrosou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da04c536b5af54726ab358bd2c2dc98a
https://doi.org/10.1002/(sici)1520-6866(1999)19:5<339::aid-tcm4>3.0.co
https://doi.org/10.1002/(sici)1520-6866(1999)19:5<339::aid-tcm4>3.0.co
Publikováno v:
Analytical Letters. 31:1603-1622
For approximately thirty years, the facilities at Rocky Mountain Arsenal were used for producing, packaging, and shipping sulfur- and phosphorus-containing mustard, Sarin, and pesticides. Degradation and manufacturing by-products related to these spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab462631d25de3d989f2898ae0a84935
https://doi.org/10.1080/00032719808002892
https://doi.org/10.1080/00032719808002892
Publikováno v:
Journal of Environmental Science and Health, Part A. 33:213-236
The half‐life of di‐isopropyl methylphosphonate (DIMP) in ground water at 10°C was estimated to be 500 years with a 95% confidence interval of 447 to 559 years from measurements of the hydrolysis rates at four temperatures ranging between 70 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dedd34207d64962dcd1d6311b8119cd6
https://doi.org/10.1080/10934529809376728
https://doi.org/10.1080/10934529809376728
Autor:
Martha M. Moore, Kerry L. Dearfield, George R. Douglas, David J. Brusick, U.H. Ehling, Gary A. Sega
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 330:71-99
An updated review of the genotoxicity studies with acrylamide is provided. Then, using data from the studies generating quantitative information concerning heritability of genetic effects, an assessment of the heritable genetic risk presented by acry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0953e50884d254157b0b7db14e2d5c2d
https://doi.org/10.1016/0027-5107(95)00037-j
https://doi.org/10.1016/0027-5107(95)00037-j
Autor:
Kerry L. Dearfield, Gary A. Sega, Jack Favor, David Layton, John S. Wassom, David J. Brusick, George R. Douglas, Jim Burkhart
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 330:23-34
This report describes a model for producing quantitative genetic risk assessments for human populations. The model is patterned after current methods used in cancer risk analysis. The risk to humans is expressed as the number of additional dominant g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::603f0e5a13bee2426c9a04bf07c8d6d4
https://doi.org/10.1016/0027-5107(93)e0261-n
https://doi.org/10.1016/0027-5107(93)e0261-n
Publikováno v:
Environmental and Molecular Mutagenesis. 24:68-74
The extent and persistence of DMA damage and repair were investigated in mouse spermatogenic cells exposed in vivo to urethane (ethyl carbamate, EC). Adult male mice exposed to [3H]EC at 10–1,000 mg/kg were sacrificed 12 hr later. EC/metabolite bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34cd86531b7e0730172ab0c35b1a36e
https://doi.org/10.1002/em.2850240109
https://doi.org/10.1002/em.2850240109
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 249:339-349
Male mice were exposed to [3H]EtO by inhalation at different exposure rates (300 parts per million (ppm) of EtO for 1 h: 150 ppm for 2 h: 75 ppm for 4 h). The total exposure was fixed at 300 ppm-h. The amount of EtO binding to developing spermatogeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1bc52ec9c54f6aee2bb93753988cab
https://doi.org/10.1016/0027-5107(91)90009-d
https://doi.org/10.1016/0027-5107(91)90009-d
Autor:
Fernando A. Castro, Gary A. Sega, Frederik Pauwels, James Schumacher, Chris W. Rogers, Roger C. Carroll, Troy E. C. Holder
Publikováno v:
American journal of veterinary research. 69(5)
Objective—To determine whether clinically effective concentrations of methylprednisolone or triamcinolone can be achieved in the navicular bursa after injection of methylprednisolone acetate (MPA) or triamcinolone acetonide (TA) into the distal int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0a5ab2544ea7ce47bac49c85b30fbb
https://pubmed.ncbi.nlm.nih.gov/18447791
https://pubmed.ncbi.nlm.nih.gov/18447791