Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Gary A. Jarvis"'
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 9 (2024)
ABSTRACT We previously reported that a linear cationic 12-amino acid cell-penetrating peptide (CPP) was bactericidal for Neisseria gonorrhoeae. In this study, our objectives were to determine the effect of cyclization of the linear CPP on its antibac
Externí odkaz:
https://doaj.org/article/6dfecc7c602443cd8a5430b074496dc9
Autor:
Amaris J. Cardenas, Keena S. Thomas, Mary W. Broden, Noel J. Ferraro, Marcos M. Pires, Constance M. John, Gary A. Jarvis, Alison K. Criss
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTGonorrhea, caused by the bacterium Neisseria gonorrhoeae (Gc), is characterized by neutrophilic influx to infection sites. Gc has developed mechanisms to resist killing by neutrophils that include modifications to its surface lipooligosacchar
Externí odkaz:
https://doaj.org/article/7f6122ee6b0e4c4a85bfb334024f3999
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The alarming rise of antibiotic resistance and the emergence of new vaccine technologies have increased the focus on vaccination to control gonorrhea. Neisseria gonorrhoeae strains FA1090 and MS11 have been used in challenge studies in human males. W
Externí odkaz:
https://doaj.org/article/4d8f9c6f83c24f56b590bb1b4194c56d
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 11, Pp 1437-1449 (2020)
Among the virulence factors in Neisseria infections, a major inducer of inflammatory cytokines is the lipooligosaccharide (LOS). The activation of NF-κB via extracellular binding of LOS or lipopolysaccharide (LPS) to the toll-like receptor 4 and its
Externí odkaz:
https://doaj.org/article/f4edb99bf329417285f809e9f3d41afa
Autor:
Katja Brunner, Constance M. John, Nancy J. Phillips, Dagmar G. Alber, Matthew R. Gemmell, Richard Hansen, Hans L. Nielsen, Georgina L. Hold, Mona Bajaj-Elliott, Gary A. Jarvis
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1893-1905 (2018)
The pathogenicity of Campylobacter concisus, increasingly found in the human gastrointestinal (GI) tract, is unclear. Some studies indicate that its role in GI conditions has been underestimated, whereas others suggest that the organism has a commens
Externí odkaz:
https://doaj.org/article/7a827cf87a674a91b5b8e8d9711f5d22
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 424-438 (2009)
Fine differences in the phosphorylation and acylation of lipooligosaccharide (LOS) from Neisseria species are thought to profoundly influence the virulence of the organisms and the innate immune responses of the host, such as signaling through toll-l
Externí odkaz:
https://doaj.org/article/3a5478c8aa344e41b40014c78601a415
Autor:
Christopher Mullally, Keith A Stubbs, Van C Thai, Anandhi Anandan, Stephanie Bartley, Martin J Scanlon, Gary A Jarvis, Constance M John, Katherine Y L Lim, Courtney M Sullivan, Mitali Sarkar-Tyson, Alice Vrielink, Charlene M Kahler
Publikováno v:
The Journal of antimicrobial chemotherapy. 77(9)
Objectives Neisseria gonorrhoeae is an exclusively human pathogen that commonly infects the urogenital tract resulting in gonorrhoea. Empirical treatment of gonorrhoea with antibiotics has led to multidrug resistance and the need for new therapeutics
Autor:
Zheng Gong, M Matt Tang, Xueliang Wu, Nancy Phillips, Dariusz Galkowski, Gary A Jarvis, Huizhou Fan
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147637 (2016)
Microbe-derived lactic acid protects women from pathogens in their genital tract. The purpose of this study was to determine lactic acid susceptibility of Neisseria gonorrhoeae, and identify potential acid resistance mechanisms present in this pathog
Externí odkaz:
https://doaj.org/article/6344731e3ffd4bd7abf3d651c80aa114
Autor:
Georgina L. Hold, Constance M. John, Matthew Gemmell, Katja Brunner, Gary A. Jarvis, Mona Bajaj-Elliott, Dagmar Alber, Hans Linde Nielsen, Nancy J. Phillips, Richard Hansen
Publikováno v:
Brunner, K, John, C M, Phillips, N J, Alber, D G, Gemmell, M R, Hansen, R, Nielsen, H L, Hold, G L, Bajaj-Elliott, M & Jarvis, G A 2018, ' Novel Campylobacter concisus lipooligosaccharide is a determinant of inflammatory potential and virulence ', Journal of Lipid Research, vol. 59, no. 10, pp. 1893-1905 . https://doi.org/10.1194/jlr.M085860
Journal of Lipid Research, Vol 59, Iss 10, Pp 1893-1905 (2018)
Journal of lipid research, vol 59, iss 10
Journal of Lipid Research, Vol 59, Iss 10, Pp 1893-1905 (2018)
Journal of lipid research, vol 59, iss 10
The pathogenicity of Campylobacter concisus, increasingly found in the human gastrointestinal (GI) tract, is unclear. Some studies indicate that its role in GI conditions has been underestimated, whereas others suggest that the organism has a commens
Publikováno v:
The Journal of antimicrobial chemotherapy. 74(11)
Objectives Cell-penetrating peptides (CPPs) have been evaluated for intracellular delivery of molecules and several CPPs have bactericidal activity. Our objectives were to determine the effect of a 12 amino acid CPPs on survival and on the invasive a