Zobrazeno 1 - 10 of 313 pro vyhledávání: '"Gary A. Cline"'
1
Akademický článek
MMAB promotes negative feedback control of cholesterol homeostasis
Autor: Leigh Goedeke, Alberto Canfrán-Duque, Noemi Rotllan, Balkrishna Chaube, Bonne M. Thompson, Richard G. Lee, Gary W. Cline, Jeffrey G. McDonald, Gerald I. Shulman, Miguel A. Lasunción, Yajaira Suárez, Carlos Fernández-Hernando
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms governing cholesterol homeostasis remain incompletely understood. Here, the authors develop an integrative genomic strategy to identify MMAB, and enzyme in the adenosylcobalamin pathway, as a regulator of hepatic LDLR activity and chol
Externí odkaz: https://doaj.org/article/822cd3ae48234a3c882c3e30c74ffa1c
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2
Akademický článek
Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice
Autor: Abudukadier Abulizi, Daniel F. Vatner, Zhang Ye, Yongliang Wang, Joao-Paulo Camporez, Dongyan Zhang, Mario Kahn, Kun Lyu, Alaa Sirwi, Gary W. Cline, M. Mahmood Hussain, Patricia Aspichueta, Varman T. Samuel, Gerald I. Shulman
Publikováno v: Journal of Lipid Research, Vol 61, Iss 12, Pp 1565-1576 (2020)
Microsomal triglyceride transfer protein (MTTP) deficiency results in a syndrome of hypolipidemia and accelerated NAFLD. Animal models of decreased hepatic MTTP activity have revealed an unexplained dissociation between hepatic steatosis and hepatic
Externí odkaz: https://doaj.org/article/4a127f1e875f4bd1bff152707a536e82
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3
Akademický článek
A role for foregut tyrosine metabolism in glucose tolerance
Autor: Judith Korner, Gary W. Cline, Mark Slifstein, Pasquale Barba, Gina R. Rayat, Gerardo Febres, Rudolph L. Leibel, Antonella Maffei, Paul E. Harris
Publikováno v: Molecular Metabolism, Vol 23, Iss , Pp 37-50 (2019)
Objective: We hypothesized that DA and L-DOPA derived from nutritional tyrosine and the resultant observed postprandial plasma excursions of L-DOPA and DA might affect glucose tolerance via their ability to be taken-up by beta cells and inhibit gluco
Externí odkaz: https://doaj.org/article/d94b5337b8b045778ae5b9d0c8c596db
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5
Akademický článek
Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
Autor: Rachel J. Perry, Liang Peng, Gary W. Cline, Gina M. Butrico, Yongliang Wang, Xian-Man Zhang, Douglas L. Rothman, Kitt Falk Petersen, Gerald I. Shulman
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Liver mitochondrial metabolism plays an important role for glucose and lipid homeostasis and its alterations contribute to metabolic disorders, including fatty liver and diabetes. Here Perry et al. develop a method for the measurement of hepatic flux
Externí odkaz: https://doaj.org/article/ccfedb92246c4972a9596277dbe5a31b
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6
Akademický článek
Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages
Autor: Elisa Araldi, Marta Fernández-Fuertes, Alberto Canfrán-Duque, Wenwen Tang, Gary W. Cline, Julio Madrigal-Matute, Jordan S. Pober, Miguel A. Lasunción, Dianqing Wu, Carlos Fernández-Hernando, Yajaira Suárez
Publikováno v: Cell Reports, Vol 19, Iss 13, Pp 2743-2755 (2017)
Macrophages perform critical functions in both innate immunity and cholesterol metabolism. Here, we report that activation of Toll-like receptor 4 (TLR4) in macrophages causes lanosterol, the first sterol intermediate in the cholesterol biosynthetic
Externí odkaz: https://doaj.org/article/b967b084a196471a94bca71436aeadaf
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