Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Gary A. Cain"'
Autor:
Jennifer Epler, Joachim Rudolph, Joy Drobnick, Roxanne Vega, Ignacio Aliagas, Sreemathy Ramaswamy, Elizabeth Blackwood, Klaus P. Hoeflich, Diana Jakubiak, Wendy Lee, Haiming Zhang, Xianrui Zhao, Weiru Wang, Christopher E. Heise, David Favor, Chudi Ndubaku, Thomas W. O'Brien, Gary A. Cain, Lesley J. Murray, Paroma Chakravarty, Hank La, Christy C. Ong, Ping Dong, Connie Chan, James J. Crawford, Angela Oh, Yu Zhong, Dolores Díaz, Lewis J. Gazzard
Publikováno v:
Journal of medicinal chemistry. 59(11)
p21-activated kinase 1 (PAK1) has an important role in transducing signals in several oncogenic pathways. The concept of inhibiting this kinase has garnered significant interest over the past decade, particularly for targeting cancers associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0be5f9cfb402a0bbeedbcf126e00c2a
https://pubmed.ncbi.nlm.nih.gov/27167326
https://pubmed.ncbi.nlm.nih.gov/27167326
Autor:
Melissa Estrella, Christopher A. Teleha, Gary A. Cain, Alfred J. Mical, Andrew M. Blum, Edd R. Holler, James S. Piecara, George C. Emmett, Dean A. Wacker
Publikováno v:
Synthesis. 2005:92-96
Methods for the preparation of (3S)-3-(4-fluorobenzyl)piperidine (2) and its mandelate salt (9) are described. The first generation synthesis started from 3-benzylpiperidone, and required Boc protection of the nitrogen for efficient separation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32a41940b9728638926eda6d6cec68db
https://doi.org/10.1055/s-2004-834903
https://doi.org/10.1055/s-2004-834903
Autor:
Gary M. Cain
Publikováno v:
Compensation & Benefits Review. 35:36-42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ddc64575d3801afb875e16a2c8f4ee4
https://doi.org/10.1177/0886368703251165
https://doi.org/10.1177/0886368703251165
Autor:
Argyrios G, Arvanitis, Joseph T, Rescinito, Charles R, Arnold, Richard G, Wilde, Gary A, Cain, Jung Hui, Sun, Jia-Sheng, Yan, Christopher A, Teleha, Lawrence W, Fitzgerald, John, McElroy, Robert, Zaczek, Paul R, Hartig, Scott, Grossman, Stephen P, Arneric, Paul J, Gilligan, Richard E, Olson, David W, Robertson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:125-128
A series of high affinity CRF receptor ligands with an imidazo[4,5-b]pyridine core is described. Individual analogues were synthesized and tested in a rat CRF receptor binding assay. The best compounds were further tested in the dog N-in-1 pharmacoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057e389865579ec966662dc7ddd358a7
https://doi.org/10.1016/s0960-894x(02)00833-8
https://doi.org/10.1016/s0960-894x(02)00833-8
Autor:
Gary A. Cain, Spencer Drummond
Publikováno v:
Synthetic Communications. 30:4513-4521
Naloxone 3-methyl ether was selectively oxidized by treatment with cerium ammonium nitrate in aqueous acetonitrile at ambient temperature to provide the 10-(S)-hydroxy adduct. The stereochemistry of the oxidation product was proven by single crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20819d5e5bb6eeb4934fd23dad680bbf
https://doi.org/10.1080/00397910008087081
https://doi.org/10.1080/00397910008087081
Autor:
Gary Avonn Cain
Publikováno v:
Organic Preparations and Procedures International. 32:88-91
(2000). AN IMPROVED SYNTHESIS OF 3-CYANO-4-FLUOROBENZYL BROMIDE. Organic Preparations and Procedures International: Vol. 32, No. 1, pp. 88-91.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b9a9562c5e50da49cb6c5a75b9edc0
https://doi.org/10.1080/00304940009356752
https://doi.org/10.1080/00304940009356752
Autor:
Gary A. Cain, Christopher A. Teleha
Publikováno v:
Organic Preparations and Procedures International. 32:96-99
(2000). A CONVENIENT SYNTHESIS OF N-Boc-4-FORMYLPIPERINE. Organic Preparations and Procedures International: Vol. 32, No. 1, pp. 96-99.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::073b21f9fa66345a2638a4432c0190dd
https://doi.org/10.1080/00304940009356755
https://doi.org/10.1080/00304940009356755
Autor:
Patricia P Harlow, Susan M. Spitz, Mark S. Forsythe, Ruth R. Wexler, Martha H. Corjay, Joseph J. Petraitis, Peter J. Bouchard, Gregory C. Houghton, Shaker A. Mousa, Prabhakar K. Jadhav, Frank A. Barbera, Douglas G. Batt, Dilip P. Modi, Gary A. Cain
Publikováno v:
Journal of Medicinal Chemistry. 43:41-58
A new series of indazole-containing αvβ3 integrin antagonists is described. Starting with lead compound 18a, variations in a number of structural features were explored with respect to inhibition of the binding of β3-transfected 293 cells to fibri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cb1e0dfb66424a070cd1095d9734008
https://doi.org/10.1021/jm990049j
https://doi.org/10.1021/jm990049j
Autor:
Chu-Biao Xue, John Wityak, Thais M. Sielecki, Donald J. Pinto, Douglas G. Batt, Gary A. Cain, Michael Sworin, Arlene L. Rockwell, John J. Roderick, Shuaige Wang, Michael J. Orwat, William E. Frietze, Lori L. Bostrom, Jie Liu, C. Anne Higley, F. Wayne Rankin, A. Ewa Tobin, George Emmett, George K. Lalka, Jean Y. Sze, Susan V. Di Meo, Shaker A. Mousa, Martin J. Thoolen, Adrienne L. Racanelli, Elizabeth A. Hausner, Thomas M. Reilly, William F. DeGrado, Ruth R. Wexler, Richard E. Olson
Publikováno v:
Journal of Medicinal Chemistry. 40:2064-2084
Using isoxazoline XR299 (1a) as a starting point for the design of highly potent, long-duration GPIIb/IIIa antagonists, the effect of placing lipophilic substituents at positions alpha and beta to the carboxylate moiety was evaluated. Of the compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9b542866bf589da6d073fd44e05bd5
https://doi.org/10.1021/jm960799i
https://doi.org/10.1021/jm960799i
Publikováno v:
Biochemistry. 35:1270-1273
The active metabolite of leflunomide. A771726, is a novel immunosuppressive compound that has been shown to be a powerful antiproliferative agent for mononuclear and T-cells. The molecular mechanism of action for this compound has not been clearly es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e0f91c80b39515063da7c14232555e
https://doi.org/10.1021/bi952168g
https://doi.org/10.1021/bi952168g