Zobrazeno 1 - 10
of 467
pro vyhledávání: '"Gary A Rosenberg"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
BackgroundAdvances in in vivo MRI techniques enable cerebral barrier transfer rates (Ktrans) measurement in patients with vascular cognitive impairment and dementia (VCID). However, a consensus has not been reached on the dynamic contribution and imp
Externí odkaz:
https://doaj.org/article/a52764e5704d4a60810801545901fb37
Autor:
Jeff W Hill, Jeffrey F Thompson, Mark B Carter, Bruce S Edwards, Larry A Sklar, Gary A Rosenberg
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96761 (2014)
Stroke is a leading cause of death and disability and treatment options are limited. A promising approach to accelerate the development of new therapeutics is the use of high-throughput screening of chemical libraries. Using a cell-based high-through
Externí odkaz:
https://doaj.org/article/76d02db473a94b489c57b1d1b3787c97
Autor:
Danielle C. Hergert, Owen Gaasedelen, Sephira G. Ryman, Jillian Prestopnik, Arvind Caprihan, Gary A. Rosenberg
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 14 (2024)
Background The purpose of this study was to investigate the relationship between blood–brain barrier (BBB) permeability and cognitive functioning in healthy older adults and individuals with neurodegenerative diseases. Methods and Results A total o
Externí odkaz:
https://doaj.org/article/fa7fe878d8c94be0806e51f74706c70d
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6597 (2009)
Variations in apparent diffusion coefficient of water (ADC) and blood-brain barrier (BBB) permeability after ischemia have been suggested, though the correlation between ADC alterations and BBB opening remains to be studied. We hypothesized that ther
Externí odkaz:
https://doaj.org/article/42edeaf0f1f044308ffc46107d30ff09
Autor:
Kathryn E. Sánchez, Shanya Jiang, Sharina Palencia Desai, Jeffery Thompson, Sasha Hobson, Gary A. Rosenberg, Kiran Bhaskar
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102916- (2024)
Summary: Apoptosis-associated speck-like protein containing a c-terminal caspase activation and recruitment domain (ASC) specks are elevated in the cerebrospinal fluid (CSF) of Alzheimer’s disease and related dementias (AD/ADRDs) patients. Here, we
Externí odkaz:
https://doaj.org/article/cdb71a31e5af421cb405829c89c0a119
Autor:
Arvind Caprihan, Laura Hillmer, Erik Barry Erhardt, John C. Adair, Janice E. Knoefel, Jillian Prestopnik, Gary A. Rosenberg, for Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 10, Pp 1802-1815 (2023)
Abstract Introduction Diagnosis of dementia in the aging brain is confounded by the presence of multiple pathologies. Mixed dementia (MX), a combination of Alzheimer's disease (AD) proteins with vascular disease (VD), is frequently found at autopsy,
Externí odkaz:
https://doaj.org/article/770232db29f046f8b664576411a926f5
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Inflammation contributes to amyloid-β and tau pathology in Alzheimer’s disease (AD). Microglia facilitate an altered immune response that includes microgliosis, upregulation of inflammasome proteins, and elevation of matrix-metalloproteinases (MMP
Externí odkaz:
https://doaj.org/article/46de3c30db5347a4b84c8cd043e8ba03
Autor:
Gary A. Rosenberg
The molecular basis for the physiology of the brain has advanced enormously in the past twenty years with an influx of new information gleaned through technological developments in neuroimaging and molecular discoveries. Molecular Physiology and Meta
Autor:
Anders Wallin, Suvarna Alladi, Sandra E Black, Christopher Chen, Steven M Greenberg, Deborah Gustafson, Jeremy D Isaacs, Hanna Jokinen, Raj Kalaria, Vincent Mok, Leonardo Pantoni, Florence Pasquier, Gustavo C Roman, Gary A. Rosenberg, Reinhold Schmidt, Eric E Smith, Atticus H Hainsworth
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 3, Iss , Pp 100044- (2022)
Externí odkaz:
https://doaj.org/article/bc1f1d7d163b486482fc3e467dcd6041
Autor:
Shanya Jiang, Nicole M. Maphis, Jessica Binder, Devon Chisholm, Lea Weston, Walter Duran, Crina Peterson, Amber Zimmerman, Michael A. Mandell, Stephen D. Jett, Eileen Bigio, Changiz Geula, Nikolaos Mellios, Jason P. Weick, Gary A. Rosenberg, Eicke Latz, Michael T. Heneka, Kiran Bhaskar
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109720- (2021)
Summary: Pathological hyperphosphorylation and aggregation of tau (pTau) and neuroinflammation, driven by interleukin-1β (IL-1β), are the major hallmarks of tauopathies. Here, we show that pTau primes and activates IL-1β. First, RNA-sequence analy
Externí odkaz:
https://doaj.org/article/d7ff525d710c4c41847bd98e6f7f0a7b