Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Gary A B Armstrong"'
Glial Hsp70 protects K+ homeostasis in the Drosophila brain during repetitive anoxic depolarization.
Autor:
Gary A B Armstrong, Chengfeng Xiao, Jennifer L Krill, Laurent Seroude, Ken Dawson-Scully, R Meldrum Robertson
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28994 (2011)
Neural tissue is particularly vulnerable to metabolic stress and loss of ion homeostasis. Repetitive stress generally leads to more permanent dysfunction but the mechanisms underlying this progression are poorly understood. We investigated the effect
Externí odkaz:
https://doaj.org/article/a71ed44178764998a4cce4275021cf71
Publikováno v:
PLoS ONE, Vol 2, Iss 8, p e773 (2007)
Although it is acknowledged that genetic variation contributes to individual differences in thermotolerance, the specific genes and pathways involved and how they are modulated by the environment remain poorly understood. We link natural variation in
Externí odkaz:
https://doaj.org/article/c316400c518c4563b32b767a8f36f108
Autor:
Corinne I Rodgers, Gary A B Armstrong, Kelly L Shoemaker, John D LaBrie, Christopher D Moyes, R Meldrum Robertson
Publikováno v:
PLoS ONE, Vol 2, Iss 12, p e1366 (2007)
Cortical spreading depression (CSD) is closely associated with important pathologies including stroke, seizures and migraine. The mechanisms underlying SD in its various forms are still incompletely understood. Here we describe SD-like events in an i
Externí odkaz:
https://doaj.org/article/1bf69552590f49e29283bf18d65e2596
Efficacy of Ciprofloxacin/Celecoxib combination in zebrafish models of amyotrophic lateral sclerosis
Autor:
Hagit Goldshtein, Alexandre Muhire, Virginie Petel Légaré, Avital Pushett, Ron Rotkopf, Jeremy M. Shefner, Randall T Peterson, Gary A. B. Armstrong, Niva Russek‐ Blum
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 10, Pp 1883-1897 (2020)
Abstract Objective To evaluate the efficacy of a fixed‐dose combination of two approved drugs, Ciprofloxacin and Celecoxib, as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS). Methods Toxicity and efficacy of Ciprofloxacin
Externí odkaz:
https://doaj.org/article/b113a40b6b6d4087b0de396e6c9a5c30
Autor:
Virginie Petel Légaré, Christian J. Rampal, Tyler J. N. Gurberg, Mari J. Aaltonen, Alexandre Janer, Lorne Zinman, Eric A. Shoubridge, Gary A. B. Armstrong
Publikováno v:
Developmental Neurobiology. 83:54-69
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52db07b39db37b6a634829f52ddbfdec
https://doi.org/10.1002/dneu.22909
https://doi.org/10.1002/dneu.22909
Autor:
Rahul Kumar, Vincent Francis, Gopinath Kulasekaran, Maleeha Khan, Gary A. B. Armstrong, Peter S. McPherson
Publikováno v:
Science advances. 8(8)
Primary cilia are sensory antennae crucial for cell and organism development, and defects in their biogenesis cause ciliopathies. Ciliogenesis involves membrane trafficking mediated by small guanosine triphosphatases (GTPases) including Rabs, molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865c2ecf3b524699c96ea1b46e9b7ebe
https://pubmed.ncbi.nlm.nih.gov/35196081
https://pubmed.ncbi.nlm.nih.gov/35196081
Autor:
Gary A. B. Armstrong, Xavier Allard-Chamard, Esteban C. Rodríguez, Virginie Petel Légaré, Christian J. Rampal, Ziyaan A. Harji
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Though there is compelling evidence that de-innervation of neuromuscular junctions (NMJ) occurs early in amyotrophic lateral sclerosis (ALS), defects arising at synapses in the spinal cord remain incompletely understood. To investigate spinal cord sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58e0dd1993f93f07b61dc4d6a9fe88c
http://link.springer.com/article/10.1038/s41598-019-45530-3
http://link.springer.com/article/10.1038/s41598-019-45530-3
Efficacy of Ciprofloxacin/Celecoxib combination in zebrafish models of amyotrophic lateral sclerosis
Autor:
Avital Pushett, Virginie Petel Légaré, Hagit Goldshtein, Ron Rotkopf, Jeremy M. Shefner, Niva Russek‐ Blum, Randall T. Peterson, Gary A. B. Armstrong, Alexandre Muhire
Publikováno v:
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, Vol 7, Iss 10, Pp 1883-1897 (2020)
Annals of Clinical and Translational Neurology, Vol 7, Iss 10, Pp 1883-1897 (2020)
Objective To evaluate the efficacy of a fixed‐dose combination of two approved drugs, Ciprofloxacin and Celecoxib, as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS). Methods Toxicity and efficacy of Ciprofloxacin and Cele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4a6aaac62b73b1486459775d4789fd
https://pubmed.ncbi.nlm.nih.gov/32915525
https://pubmed.ncbi.nlm.nih.gov/32915525
Autor:
Stuart Pickering-Brown, Marilou Bouffard, Janis Bennion Callister, Pierre Drapeau, Amrutha Swaminathan, Gary A. B. Armstrong, Sarah Ryan, Meijiang Liao
Publikováno v:
Human Molecular Genetics. 27:1754-1762
Large expansions of hexanucleotide GGGGCC (G4C2) repeats (hundreds to thousands) in the first intron of the chromosome 9 open reading frame 72 (C9orf72) locus are the strongest known genetic factor associated with amyotrophic lateral sclerosis and fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7614ea457a7bd67393b2fb70df2e8cf
https://doi.org/10.1093/hmg/ddy083
https://doi.org/10.1093/hmg/ddy083
Autor:
Gary A. B. Armstrong, Poulomee Bose, Christopher Barden, Claudia Maios, J. Alex Parker, Vijay Narasimhan, Richard Robitaille, Xiao-Yan Wen, Meijiang Liao, Elsa Tremblay, Pierre Drapeau
Publikováno v:
Neurotherapeutics
Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder in which the neuromuscular junction progressively degenerates, leading to movement difficulties, paralysis, and eventually death. ALS is currently being treated by only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83ce053bfcebbef6363ad766f1f08c6
https://europepmc.org/articles/PMC6985319/
https://europepmc.org/articles/PMC6985319/
