Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Gary A, Sulikowski"'
Publikováno v:
ACS Omega, Vol 9, Iss 35, Pp 37025-37034 (2024)
Externí odkaz:
https://doaj.org/article/87811b9141474157bb89b65c47f37659
Autor:
Shajila Siricilla, Christopher J. Hansen, Jackson H. Rogers, Debasmita De, Carolyn L. Simpson, Alex G. Waterson, Gary A. Sulikowski, Stacey L. Crockett, Naoko Boatwright, Jeff Reese, Bibhash C. Paria, J. Newton, Jennifer L. Herington
Publikováno v:
Pharmacological Research, Vol 195, Iss , Pp 106876- (2023)
There is a lack of FDA-approved tocolytics for the management of preterm labor (PL). In prior drug discovery efforts, we identified mundulone and mundulone acetate (MA) as inhibitors of in vitro intracellular Ca2+-regulated myometrial contractility.
Externí odkaz:
https://doaj.org/article/8b5a89fb307b43c0bf0c44f354bc7013
Autor:
Francis J. Prael III, Kwangho Kim, Yu Du, Brittany D. Spitznagel, Gary A. Sulikowski, Eric Delpire, C. David Weaver
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
KCC2 is a K+-Cl− cotransporter that is expressed in neurons throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism spectrum disorders, a
Externí odkaz:
https://doaj.org/article/494279392eab412885fe7d235f350b87
Autor:
Jonah E. Zarrow, Jianhua Tian, Brendan Dutter, Kwangho Kim, Amanda C. Doran, Gary A. Sulikowski, Sean S. Davies
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 1, Pp 100156- (2022)
N-acyl-phosphatidylethanolamine (NAPE)-hydrolyzing phospholipase D (NAPE-PLD) is a zinc metallohydrolase enzyme that converts NAPEs to bioactive N-acyl-ethanolamides. Altered NAPE-PLD activity may contribute to pathogenesis of obesity, diabetes, athe
Externí odkaz:
https://doaj.org/article/5e58933ec3924ae6a69a3726475555e9
Autor:
Carole A. Bewley, Gary A. Sulikowski, Zhongyue J. Yang, Giuseppe Bifulco, Hyo-Moon Cho, Christopher R. Fullenkamp
Publikováno v:
Accounts of Chemical Research. 56:414-424
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fa979b95e8f509c96b338eadec8a6e3
https://doi.org/10.1021/acs.accounts.2c00648
https://doi.org/10.1021/acs.accounts.2c00648
Autor:
Lillian J. Juttukonda, William N. Beavers, Daisy Unsihuay, Kwangho Kim, Gleb Pishchany, Kyle J. Horning, Andy Weiss, Hassan Al-Tameemi, Jeffrey M. Boyd, Gary A. Sulikowski, Aaron B. Bowman, Eric P. Skaar
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Metals are essential nutrients that all living organisms acquire from their environment. While metals are necessary for life, excess metal uptake can be toxic; therefore, intracellular metal levels are tightly regulated in bacterial cells. S
Externí odkaz:
https://doaj.org/article/1260e5a12a7c4059be846aa784f59aa4
Autor:
Haruto Yamanashi, William E. Boeglin, Christophe Morisseau, Robert W. Davis, Gary A. Sulikowski, Bruce D. Hammock, Alan R. Brash
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 4, Pp 684-695 (2018)
Lipoxygenase (LOX)-catalyzed oxidation of the essential fatty acid, linoleate, represents a vital step in construction of the mammalian epidermal permeability barrier. Analysis of epidermal lipids indicates that linoleate is converted to a trihydroxy
Externí odkaz:
https://doaj.org/article/95ce9ae73c3240bfa2fcabcd000ddcec
Autor:
Kevin P. Kelly, Hugo Borsetti, Marta E. Wenzler, Alessandro Ustione, Kwangho Kim, Plamen P. Christov, Bianca Ramirez, Joshua A. Bauer, David W. Piston, Carl Hirschie Johnson, Gary A. Sulikowski
Publikováno v:
ACS Chem Biol
A high-throughput cell-based screen identified redox-active small molecules that produce a period lengthening of the circadian rhythm. The strongest period lengthening phenotype was induced by a phenazine carboxamide (VU661). Comparison to two isomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81eac32d691a448f27578095b63aa4cb
https://doi.org/10.1021/acschembio.2c00240
https://doi.org/10.1021/acschembio.2c00240
Autor:
Samantha J. McClenahan, Caitlin N. Kent, Sujay V. Kharade, Elena Isaeva, Jade C. Williams, Changho Han, Andrew Terker, Robert Gresham, Roman M. Lazarenko, Emily L. Days, Ian M. Romaine, Joshua A. Bauer, Olivier Boutaud, Gary A. Sulikowski, Raymond Harris, C. David Weaver, Alexander Staruschenko, Craig W. Lindsley, Jerod S. Denton
Publikováno v:
Mol Pharmacol
Heteromeric Kir4.1/Kir5.1 (KCNJ10/KCNJ16) inward rectifier potassium (Kir) channels play key roles in the brain and kidney, but pharmacological tools for probing their physiology and therapeutic potential have not been developed. Here, we report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4fbdcbfcd068da9cf2cba3d0be7037f
https://doi.org/10.1124/molpharm.121.000464
https://doi.org/10.1124/molpharm.121.000464
Autor:
Jonah E. Zarrow, Abdul-Musawwir Alli-Oluwafuyi, Cristina M. Youwakim, Kwangho Kim, Andrew N. Jenkins, Isabelle C. Suero, Margaret R. Jones, Zahra Mashhadi, Kenneth P. Mackie, Alex G. Waterson, Amanda C. Doran, Gary A. Sulikowski, Sean S. Davies
Publikováno v:
bioRxiv
N-acyl-phosphatidylethanolamine hydrolyzing phospholipase D (NAPE-PLD) is a zinc metallohydrolase that hydrolyzesN-acyl-phosphatidylethanolamine (NAPEs) to formN-acyl-ethanolamides (NAEs) and phosphatidic acid. Several lines of evidence suggest that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163ae61d0441803c3cded0cfa71c1fbc
https://doi.org/10.1101/2023.01.25.525554
https://doi.org/10.1101/2023.01.25.525554
