Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Gary J. Grover"'
Autor:
Naoki Kumashiro, Derek M. Erion, Roy E. Weiss, Gary J. Grover, John D. Baxter, Kevin J. Phillips, Dirk Weismann, Xiao Hui Liao, Jonathan S. Bogan, Sara A. Beddow, Varman T. Samuel, Daniel F. Vatner, Paul Webb, Gerald I. Shulman
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 305:E89-E100
Liver-specific thyroid hormone receptor-β (TRβ)-specific agonists are potent lipid-lowering drugs that also hold promise for treating nonalcoholic fatty liver disease and hepatic insulin resistance. We investigated the effect of two TRβ agonists (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80815483913b6e3faa919450b8b43144
https://doi.org/10.1152/ajpendo.00573.2012
https://doi.org/10.1152/ajpendo.00573.2012
Autor:
Michael Lyon, Gary J. Grover, Lee Koetzner, Simon Wood, Prateek Juneja, Raylene A. Reimer, Roland J. Gahler
Publikováno v:
The Journal of Nutrition. 142:1812-1820
The novel polysaccharide (NPS) PolyGlycopleX (PGX) has been shown to reduce glycemia. Pharmacological treatment with sitagliptin, a dipeptidyl peptidase 4 (DPP4) inhibitor, also reduces glycemia by increasing glucagon-like peptide-1 (GLP-1). Our obje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1924dab1ac13603afa3cd18d02884fcd
https://doi.org/10.3945/jn.112.163204
https://doi.org/10.3945/jn.112.163204
Publikováno v:
Molecular and Cellular Endocrinology. 339:72-80
Thyroid hormone (T3) suppresses cerebral gene expression of the β-amyloid precursor protein (APP), an integral membrane protein that plays a key role in the onset and progression of Alzheimer's disease. However, the mechanisms by which T3 signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e40cb846d3db4e30adf6b2f933a1b81
https://doi.org/10.1016/j.mce.2011.03.016
https://doi.org/10.1016/j.mce.2011.03.016
Autor:
Michael Lyon, Simon Wood, Gary J. Grover, Roland J. Gahler, Joan Wicks, Lee Koetzner, Raylene A. Reimer
Publikováno v:
Life Sciences. 88:392-399
Aims The effects of the novel water soluble, viscous fiber complex PolyGlycopleX® [(α- d -glucurono-α- d -manno-β- d -manno-β- d -gluco), (α- l -gulurono-β- d mannurono), β- d -gluco-β- d -mannan (PGX®)] on body weight, food consumption, gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33aedabc708e4027619135d825664a57
https://doi.org/10.1016/j.lfs.2010.11.014
https://doi.org/10.1016/j.lfs.2010.11.014
Autor:
Johan Malm, Gary J. Grover
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Thyroid hormones and thyromimetics bind their cognate receptors in the nucleus to regulate the expression of diverse genes throughout the body. Consequently, such agents represent significant promise for the development of new therapies—particularl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fe413e3ec6318dab8d389e0f0c218ee
https://doi.org/10.1002/0471266949.bmc052.pub2
https://doi.org/10.1002/0471266949.bmc052.pub2
Publikováno v:
Biomedical Chromatography. 23:973-979
A simple and sensitive analytical method using liquid chromatography-tandem mass spectrometry (LC/MS/MS) for determination of acetylsalicylic acid (aspirin, ASA) and its major metabolite, salicylic acid (SA), in animal plasma has been developed and v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc069550a20831451ad502b9df17315
https://doi.org/10.1002/bmc.1209
https://doi.org/10.1002/bmc.1209
Autor:
Stanley R. Krystek, Donald Egan, John S. Sack, Joyce E. Kuhns, Alexandra A. Nirschl, Gary J. Grover, Rajasree Golla, John A. Lupisella, James A. Bryson, John D. Dimarco, Jack Z. Gougoutas, Ligaya M. Simpkins, Aberra Fura, Jacek Ostrowski, Yan Zou, Yi-Xin Li, Robert Zahler, Yongmi An, James C. Sutton, Kevin Kish, Viral Vyas, Lawrence G. Hamann, Ramakrishna Seethala, Paul G. Sleph, Blake C. Beehler
Publikováno v:
Journal of Medicinal Chemistry. 52:2794-2798
A novel selective androgen receptor modulator (SARM) scaffold was discovered as a byproduct obtained during synthesis of our earlier series of imidazolidin-2-ones. The resulting oxazolidin-2-imines are among the most potent SARMs known, with many ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f214c0cc904cf19d8eb4d61464a864
https://doi.org/10.1021/jm801583j
https://doi.org/10.1021/jm801583j
Autor:
Gary J. Grover, Johan Malm
Publikováno v:
Cardiovascular Therapeutics. 26:287-296
The mitochondrial F1F0 ATP synthase is responsible for the majority of ATP production in mammals and does this through a rotary catalytic mechanism. Studies show that the F1F0 ATP synthase can switch to an ATP hydrolase, and this occurs under conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91cecfd1123747a18f7080a3ba168a5
https://doi.org/10.1111/j.1755-5922.2008.00065.x
https://doi.org/10.1111/j.1755-5922.2008.00065.x
Publikováno v:
Future Lipidology. 2:641-649
Thyroid hormones are of interest because of their ability to reduce serum cholesterol and triglycerides and their ability to reduce adiposity. Unfortunately, naturally occurring thyroid hormones, such as T3 (thyroid hormone) or T4 (thyroxine), cannot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69006c40078788da4c4d80784ec6b07f
https://doi.org/10.2217/17460875.2.6.641
https://doi.org/10.2217/17460875.2.6.641
Discovery, synthesis, and structure–activity studies of tetrazole based growth hormone secretagogues
Autor:
David A. Gordon, Christa M. Musial, R. Krishna Seethala, Leah Giupponi, Kenneth E.J. Dickinson, Jeffrey A. Robl, Peter T. W. Cheng, Neil Flynn, Mark A. Smith, Dorothy Slusarchyk, Joseph A. Tino, Brian J. Murphy, Stephen G. Swartz, Gary J. Grover, Andres S. Hernandez, R.J. George, Daniel Longhi, Scott A. Biller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5928-5933
A novel class of Growth Hormone Secretagogues (GHS), based on a tetrazole template, has been discovered. In vitro SAR and in vivo potency within this new class of GHS are described. The tetrazole 9q exhibits good oral bioavailability in rats and dogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1154e1211ab6b2013a35c0eb0313a1a6
https://doi.org/10.1016/j.bmcl.2007.07.099
https://doi.org/10.1016/j.bmcl.2007.07.099