Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Gary A. Gintant"'
Autor:
Hugo M. Vargas, Eric I. Rossman, Todd A. Wisialowski, Jill Nichols, Michael K. Pugsley, Brian Roche, Gary A. Gintant, Andrea Greiter-Wilke, Robert B. Kleiman, Jean-Pierre Valentin, Derek J. Leishman
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 121:107265
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be76a6ce3a2e0c4c2deec09e77581719
https://doi.org/10.1016/j.vascn.2023.107265
https://doi.org/10.1016/j.vascn.2023.107265
Autor:
Eric I. Rossman, Todd A. Wisialowski, Hugo M. Vargas, Jean-Pierre Valentin, Michael G. Rolf, Brian M. Roche, Steve Riley, Michael K. Pugsley, Jill Nichols, Dingzhou Li, Derek J. Leishman, Robert B. Kleiman, Andrea Greiter-Wilke, Gary A. Gintant, Michael J. Engwall, Annie Delaunois, Simon Authier
Publikováno v:
Journal of Pharmacological and Toxicological Methods. :107270
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bce4cdaca3426f8bebb1500bde7339b
https://doi.org/10.1016/j.vascn.2023.107270
https://doi.org/10.1016/j.vascn.2023.107270
Autor:
James L, Januzzi, John M, Canty, Saumya, Das, Christopher R, DeFilippi, Gary A, Gintant, David E, Gutstein, Allan, Jaffe, Emily P, Kaushik, Christopher, Leptak, Cyrus, Mehta, Ileana, Pina, Thomas J, Povsic, Curtis, Rambaran, Rhonda F, Rhyne, Maribel, Salas, Victor C, Shi, Jacob A, Udell, Ellis F, Unger, Tanja S, Zabka, Jonathan H, Seltzer
Publikováno v:
Journal of the American College of Cardiology. 77(15)
The momentum of cardiovascular drug development has slowed dramatically. Use of validated cardiac biomarkers in clinical trials could accelerate development of much-needed therapies, but biomarkers have been used less for cardiovascular drug developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76fc882b78dd9efbb144709c0cb31440
https://pubmed.ncbi.nlm.nih.gov/33858628
https://pubmed.ncbi.nlm.nih.gov/33858628
Autor:
Thomas K. Baker, Radhakrishna Sura, Josesph Cichocki, David M Stresser, Paul Levesque, Diane Ramsden, Myrtle Davis, Gary A. Gintant, Christopher M. Hale, Jonathan Maher, Amy Pointon, Kyle L. Kolaja
Publikováno v:
Lab on a chip. 21(3)
The integrative responses of the cardiovascular (CV) system are essential for maintaining blood flow to provide oxygenation, nutrients, and waste removal for the entire body. Progress has been made in independently developing simple in vitro models o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58ac64ab0b3f6fceab193d783353528
https://pubmed.ncbi.nlm.nih.gov/33471007
https://pubmed.ncbi.nlm.nih.gov/33471007
Autor:
Charles Benson, Yasunari Kanda, David G. Strauss, Rob Wallis, Borje Darpo, Jean-Pierre Valentin, Gary A. Gintant, Krishna Prasad
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:15-25
The Safety Pharmacology Society organized a scientific session at its annual conference in 2017 to discuss the challenges and opportunities of the Comprehensive In-Vitro Proarrhythmia Assay (CiPA) paradigm. Our intention was to raise awareness of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5204946c49cc9d69154b2a763721aabc
https://doi.org/10.1016/j.vascn.2018.06.005
https://doi.org/10.1016/j.vascn.2018.06.005
Autor:
Yevgeniya E. Koshman, Amanda S. Wilsey, Brandan M. Bird, Sabine Sadilek, Debra A. Weisbecker, Paige A. Ebert, Kuldip K. Mirakhur, James S. Polakowski, Gary A. Gintant, C. Michael Foley, Scott W. Mittelstadt
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 111:107003
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c45e5c67a8c524de97cc0c0a12b9ec2b
https://doi.org/10.1016/j.vascn.2021.107003
https://doi.org/10.1016/j.vascn.2021.107003
Autor:
Brian R. Berridge, Mathew Brock, Yasunari Kanda, C. Michael Foley, Stanley T. Parish, Jennifer B. Pierson, Liang Guo, Sandy Eldridge, Khuram W. Chaudhary, Gary A. Gintant, Michael J. Engwall, Brian Guth, Alexandre J.S. Ribeiro, John Koerner
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human cardiomyocytes in vitro can provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7dab8b3c2e77857108416def7023a6f
https://doi.org/10.3389/fphar.2019.00934
https://doi.org/10.3389/fphar.2019.00934
Autor:
Brian R. Berridge, Sandy Eldridge, Liang Guo, Stanley T. Parish, Yasunari Kanda, John Koerner, Jennifer B. Pierson, C. Michael Foley, Khuram W. Chaudhary, Tanja S. Zabka, Michael J. Engwall, Gary A. Gintant, Brian Guth, Alexandre J.S. Ribeiro
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology, Vol 10 (2019)
Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted at the late stage of preclini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad621c7d50a631f678bb7d03b1ccc52
https://www.frontiersin.org/articles/10.3389/fphar.2019.00884/pdf
https://www.frontiersin.org/articles/10.3389/fphar.2019.00884/pdf
Autor:
Jack Reynolds, Andrea Ghetti, Yannick Miron, Paul Miller, Guido Steiner, Ken Wang, Phachareeya Ratchada, Guy Page, Najah Abi-Gerges, Gary A. Gintant, Andrea Greiter-Wilke, Liudmila Polonchuk, Martin Traebert
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 81:183-195
While current S7B/E14 guidelines have succeeded in protecting patients from QT-prolonging drugs, the absence of a predictive paradigm identifying pro-arrhythmic risks has limited the development of valuable drug programs. We investigated if a human e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce44be7208e69c14aaa4367e5bb7f94e
https://doi.org/10.1016/j.vascn.2016.05.016
https://doi.org/10.1016/j.vascn.2016.05.016
Autor:
Yevgeniya E. Koshman, James S. Polakowski, Scott W. Mittelstadt, Amanda S. Wilsey, Gary A. Gintant, Brandan M. Bird
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106757
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16af4ef8607279cfe6af3209f57b508b
https://doi.org/10.1016/j.vascn.2020.106757
https://doi.org/10.1016/j.vascn.2020.106757