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Akademický článek

FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion‐positive rhabdomyosarcomas

Publikováno v: Molecular Oncology, Vol 16, Iss 6, Pp 1272-1289 (2022)

Rhabdomyosarcomas are aggressive pediatric soft‐tissue sarcomas and include high‐risk PAX3–FOXO1 fusion‐gene‐positive cases. Fibroblast growth factor receptor 4 (FGFR4) is known to contribute to rhabdomyosarcoma progression; here, we sought

Externí odkaz: https://doaj.org/article/5b496d1e847c44f09cabb855a8b74715

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Akademický článek

Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice

Autor: Nigel Bush, Andrew Healey, Anant Shah, Gary Box, Vladimir Kirkin, Sue Eccles, Per Christian Sontum, Spiros Kotopoulis, Svein Kvåle, Annemieke van Wamel, Catharina de Lange Davies, Jeffrey Bamber

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

IntroductionAcoustic cluster therapy (ACT) comprises co-administration of a formulation containing microbubble/microdroplet clusters (PS101), together with a regular medicinal drug (e.g., a chemotherapeutic) and local ultrasound (US) insonation of th

Externí odkaz: https://doaj.org/article/f2bf4ce5386d49caa1e0235ee5b4f708

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Akademický článek

Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging

Autor: Anant Shah, Nigel Bush, Gary Box, Suzanne Eccles, Jeffrey Bamber

Publikováno v: Photoacoustics, Vol 8, Iss C, Pp 15-27 (2017)

Optoacoustic imaging (OAI) can detect haemoglobin and assess its oxygenation. However, the lack of a haemoglobin signal need not indicate a lack of perfusion. This study uses a novel method to assist the co-registration of optoacoustic images with dy

Externí odkaz: https://doaj.org/article/4a58b230476c444786094a2fcc1d633e

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Akademický článek

Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI

Autor: Jessica K.R. Boult, Gary Box, Maria Vinci, Lara Perryman, Suzanne A. Eccles, Chris Jones, Simon P. Robinson

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 9, Pp 684-694 (2017)

Vascular endothelial growth factor A (VEGF-A) is considered one of the most important factors in tumor angiogenesis, and consequently, a number of therapeutics have been developed to inhibit VEGF signaling. Therapeutic strategies to target brain mali

Externí odkaz: https://doaj.org/article/e311da93a57e4dada4f26c73da4eee2a

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Akademický článek

Therapeutic Dose Response of Acoustic Cluster Therapy in Combination With Irinotecan for the Treatment of Human Colon Cancer in Mice

Autor: Nigel Bush, Andrew Healey, Anant Shah, Gary Box, Vladimir Kirkin, Spiros Kotopoulis, Svein Kvåle, Per Christian Sontum, Jeffrey Bamber

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Introduction: Acoustic Cluster Therapy (ACT) comprises coadministration of a formulation containing microbubble-microdroplet clusters (PS101) together with a regular medicinal drug and local ultrasound (US) insonation of the targeted pathological tis

Externí odkaz: https://doaj.org/article/11d08ad546e74f209522240221b776ca

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