Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Garwood, C.J."'
Autor:
Matuszyk, M.M., Garwood, C.J., Ferraiuolo, L., Simpson, J.E., Staniforth, R.A., Wharton, S.B.
Although controversial, the amyloid cascade hypothesis remains central to the Alzheimer's disease (AD) field and posits amyloid-beta (Aβ) as the central factor initiating disease onset. In recent years, there has been an increase in emphasis on stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::4e07f5917226f54dd3298bcd125ec48e
https://eprints.whiterose.ac.uk/180533/9/jnc.15538.pdf
https://eprints.whiterose.ac.uk/180533/9/jnc.15538.pdf
Autor:
Vazquez‐Villasenor, I., Garwood, C.J., Simpson, J.E., Heath, P.R., Mortiboys, H., Wharton, S.B.
Oxidative DNA damage induces changes in the neuronal cell cycle and activates a DNA damage response to promote repair, but these processes may be altered under a chronic oxidative environment, leading to the accumulation of unrepaired DNA damage and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::893d625779b9dda34e119b2f70420863
https://eprints.whiterose.ac.uk/178513/9/ejn.15466.pdf
https://eprints.whiterose.ac.uk/178513/9/ejn.15466.pdf
Autor:
Allen, S.P., Seehra, R.S., Heath, P.R., Hall, B.P.C., Bates, J., Garwood, C.J., Matuszyk, M.M., Wharton, S.B., Simpson, J.E.
Hypoxia is a feature of neurodegenerative diseases, and can both directly and indirectly impact on neuronal function through modulation of glial function. Astrocytes play a key role in regulating homeostasis within the central nervous system, and med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3b4a941a26a0a5672792ad9fde3a324e
Autor:
Chambers, A., Bury, J.J., Minett, T., Richardson, C.D., Brayne, C., Ince, P.G., Shaw, P.J., Garwood, C.J., Heath, P.R., Simpson, J.E., Matthews, F.E., Wharton, S.B.
Diabetes mellitus is a risk factor for dementia, and nonenzymatic glycosylation of macromolecules results in formation of advanced glycation end-products (AGEs). We determined the variation in AGE formation in brains from the Cognitive Function and A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::336e6c5c407dad41f753b39b295bcb18
AIMS: Cellular senescence plays a role in organismal ageing and has been linked to persistent DNA damage in age-related diseases. Brain senescence has been described in astrocytes and microglia but is less well understood in neurones. Evidence sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::5a3487b0b54dbf6917595b8ecf9e7c75
https://eprints.whiterose.ac.uk/146632/1/NAN-2019-Vazquez-Villasenor.docx
https://eprints.whiterose.ac.uk/146632/1/NAN-2019-Vazquez-Villasenor.docx
Autor:
Fadul, M.M., Garwood, C.J., Waller, R., Garrett, N., Heath, P.R., Matthews, F.E., Brayne, C., Wharton, S.B., Simpson, J.E.
Astrocytes play a major role in the pathogenesis of a range of neurodegenerative diseases, including Alzheimer’s disease (AD), undergoing dramatic morphological and molecular changes that can cause potentially both beneficial and detrimental effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::54779efc2c7db8f222e12240d0a37a9b
https://eprints.whiterose.ac.uk/156943/1/ijms-21-00340.pdf
https://eprints.whiterose.ac.uk/156943/1/ijms-21-00340.pdf
Autor:
Ratcliffe, L.E., Vázquez Villaseñor, I., Jennings, L., Heath, P.R., Mortiboys, H., Schwartzentruber, A., Karyka, E., Simpson, J.E., Ince, P.G., Garwood, C.J., Wharton, S.B.
The insulin/insulin-like growth factor 1 (IGF1) signalling pathways are implicated in longevity and in progression of Alzheimer's disease. Previously, we showed that insulin-like growth factor 1 receptor (IGF1R) and downstream signalling transcripts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::27940dcb78f4bbe0afe3d1b153b06dea
https://eprints.whiterose.ac.uk/134026/10/1-s2.0-S0306452218305049-main.pdf
https://eprints.whiterose.ac.uk/134026/10/1-s2.0-S0306452218305049-main.pdf
Autor:
Morgan, S.V., Garwood, C.J., Jennings, L., Simpson, J.E., Castelli, L.M., Heath, P.R., Mihaylov, S.R., Vazquez Villasenor, I., Minshull, T.C., Ince, P.G., Dickman, M.J., Hautbergue, G.M., Wharton, S.B.
Occludin is a component of tight junctions, which are essential structural components of the blood brain barrier. However, occludin is expressed in cells without tight junctions, implying additional functions. We determined the expression and localis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::fee20167b2859ef4b58b78d8a1e6e3ce
https://eprints.whiterose.ac.uk/130780/10/Morgan_et_al-2018-European_Journal_of_Neuroscience.pdf
https://eprints.whiterose.ac.uk/130780/10/Morgan_et_al-2018-European_Journal_of_Neuroscience.pdf
Astrocytes have essential roles in the central nervous system and are also implicated in the pathogenesis of neurodegenerative disease. Forming non-overlapping domains, astrocytes are highly complex cells. Immunohistochemistry to a variety of protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::dc628190b11704158b474bf712275922
Astrocytes have essential roles in the central nervous system and are also implicated in the pathogenesis of neurodegenerative disease. Forming non-overlapping domains, astrocytes are highly complex cells. Immunohistochemistry to a variety of protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3d29a180fbfb1d5d9cec54d0b9b3f4e6
https://eprints.whiterose.ac.uk/103154/1/Garwood_et_al-2016-Neuropathology_and_Applied_Neurobiology.pdf
https://eprints.whiterose.ac.uk/103154/1/Garwood_et_al-2016-Neuropathology_and_Applied_Neurobiology.pdf