Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Garvita Gupta"'
Autor:
Garvita Gupta, Jianxing Song
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147278 (2016)
Hepatitis C virus (HCV) is a pathogen of global importance and nearly 200 million people are chronically infected with HCV. HCV is an enveloped single-stranded RNA virus, which is characteristic of the formation of the host membrane associated replic
Externí odkaz:
https://doaj.org/article/fe4fb6c2506247a0a0c197faf9975fe7
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134823 (2015)
Dengue genome encodes a two component protease complex (NS2B-NS3pro) essential for the viral maturation/infectivity, thus representing a key drug target. Previously, due to its "complete insolubility", the isolated NS3pro could not be experimentally
Externí odkaz:
https://doaj.org/article/852f7388d6884c278b22de90d50e11f4
Publikováno v:
F1000Research, Vol 2 (2014)
Paradoxically, aggregation of specific proteins is characteristic of many human diseases and aging, yet aggregates have increasingly been found to be unnecessary for initiating pathogenesis. Here we determined the NMR topology and dynamics of a helic
Externí odkaz:
https://doaj.org/article/4e42fa1014884dfc909734fb779be1ff
Publikováno v:
F1000Research, Vol 2 (2013)
Paradoxically, aggregation of specific proteins is characteristic of many human diseases and aging, yet aggregates have been found to be unnecessary for initiating pathogenesis. Here we determined the NMR topology and dynamics of a helical mutant in
Externí odkaz:
https://doaj.org/article/bc195c8622604b06a7c1137f80d9e97b
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39261 (2012)
Hepatitis C virus (HCV) affects nearly 200 million people worldwide and is a leading factor for serious chronic liver diseases. For replicating HCV genome, the membrane-associated replication machinery needs to be formed by both HCV non-structural pr
Externí odkaz:
https://doaj.org/article/2dfcaf8d6ead4e62adcc1a8645a9dcd9
Autor:
Shaveta Goyal, Garvita Gupta, Haina Qin, Megha Haridas Upadya, Yee Joo Tan, Vincent T K Chow, Jianxing Song
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40341 (2012)
Nearly 200 million people are infected by hepatitis C virus (HCV) worldwide. For replicating the HCV genome, the membrane-associated machinery needs to be formed by both HCV non-structural proteins (including NS5B) and human host factors such as VAPB
Externí odkaz:
https://doaj.org/article/d372bea7774d442ab91474e2d17397a7
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27072 (2011)
T46I is the second mutation on the hVAPB MSP domain which was recently identified from non-Brazilian kindred to cause a familial amyotrophic lateral sclerosis (ALS). Here using CD, NMR and molecular dynamics (MD) simulations, we characterized the str
Externí odkaz:
https://doaj.org/article/4b8dfde537b44338b7145b5522118298
Autor:
Shagun Srivastava, Amrita Roy, Jian Kang, Jiahai Shi, Liangzhong Lim, Garvita Gupta, Jianxing Song
Publikováno v:
Progress in Biophysics and Molecular Biology
Coronavirus 3C-like and Flavivirus NS2B-NS3 proteases utilize the chymotrypsin fold to harbor their catalytic machineries but also contain additional domains/co-factors. Over the past decade, we aimed to decipher how the extra domains/co-factors medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7141a6bbe22b6295cbdcd330ba0b8c4f
https://doi.org/10.1016/j.pbiomolbio.2018.08.009
https://doi.org/10.1016/j.pbiomolbio.2018.08.009
Autor:
Jianxing Song, Yee-Joo Tan, Y. Adam Yuan, Garvita Gupta, Qi Zeng, Jianping Wu, Bhaskar Barnwal, Chee-Keng Mok, Vincent T. K. Chow, Mandakhalikar Kedar Diwakar
Publikováno v:
Antiviral Research
Highlights • 2H6-antigen binding fragment forms a multimeric complex with non-structural 1 protein. • 2H6 antibody binds tightly to non-structural 1 protein. • The binding affinity reduces significantly when threonine 49 is substituted with Ala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7726049b1065738afb059ddf31a1427
http://europepmc.org/articles/PMC7113856
http://europepmc.org/articles/PMC7113856
Autor:
Sujit Dutta, Yook-Wah Choi, Yee-Joo Tan, Garvita Gupta, Burtram C. Fielding, Masayo Kotaka, Jianxing Song
Publikováno v:
The Biochemical journal. 446(1)
RNA helicases of the DEAD (Asp-Glu-Ala-Asp)-box family of proteins are involved in many aspects of RNA metabolism from transcription to RNA decay, but most of them have also been shown to be multifunctional. The DEAD-box helicase DDX5 of host cells h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51eb51e63935cb98fe1ce5c7bbc5ac5f
https://pubmed.ncbi.nlm.nih.gov/22640416
https://pubmed.ncbi.nlm.nih.gov/22640416