Výsledky vyhledávání

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Kniha

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex.

Autor: Garvita Gupta, Jianxing Song

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0147278 (2016)

Hepatitis C virus (HCV) is a pathogen of global importance and nearly 200 million people are chronically infected with HCV. HCV is an enveloped single-stranded RNA virus, which is characteristic of the formation of the host membrane associated replic

Externí odkaz: https://doaj.org/article/fe4fb6c2506247a0a0c197faf9975fe7

Zobrazit plný text záznamu

Akademický článek

NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional Dynamics.

Autor: Garvita Gupta, Liangzhong Lim, Jianxing Song

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134823 (2015)

Dengue genome encodes a two component protease complex (NS2B-NS3pro) essential for the viral maturation/infectivity, thus representing a key drug target. Previously, due to its "complete insolubility", the isolated NS3pro could not be experimentally

Externí odkaz: https://doaj.org/article/852f7388d6884c278b22de90d50e11f4

Zobrazit plný text záznamu

Akademický článek

Resolving the paradox for protein aggregation diseases: NMR structure and dynamics of the membrane-embedded P56S-MSP causing ALS imply a common mechanism for aggregation-prone proteins to attack membranes [v2; ref status: indexed, http://f1000r.es/3zl]

Autor: Haina Qin, Liangzhong Lim, Yuanyuan Wei, Garvita Gupta, Jianxing Song

Publikováno v: F1000Research, Vol 2 (2014)

Paradoxically, aggregation of specific proteins is characteristic of many human diseases and aging, yet aggregates have increasingly been found to be unnecessary for initiating pathogenesis. Here we determined the NMR topology and dynamics of a helic

Externí odkaz: https://doaj.org/article/4e42fa1014884dfc909734fb779be1ff

Zobrazit plný text záznamu

Akademický článek

Resolving the paradox for protein aggregation diseases: a common mechanism for aggregated proteins to initially attack membranes without needing aggregates [v1; ref status: indexed, http://f1000r.es/221]

Autor: Haina Qin, Liangzhong Lim, Yuanyuan Wei, Garvita Gupta, Jianxing Song

Publikováno v: F1000Research, Vol 2 (2013)

Paradoxically, aggregation of specific proteins is characteristic of many human diseases and aging, yet aggregates have been found to be unnecessary for initiating pathogenesis. Here we determined the NMR topology and dynamics of a helical mutant in

Externí odkaz: https://doaj.org/article/bc195c8622604b06a7c1137f80d9e97b

Zobrazit plný text záznamu

Akademický článek

Intrinsically unstructured domain 3 of hepatitis C Virus NS5A forms a 'fuzzy complex' with VAPB-MSP domain which carries ALS-causing mutations.

Autor: Garvita Gupta, Haina Qin, Jianxing Song

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e39261 (2012)

Hepatitis C virus (HCV) affects nearly 200 million people worldwide and is a leading factor for serious chronic liver diseases. For replicating HCV genome, the membrane-associated replication machinery needs to be formed by both HCV non-structural pr

Externí odkaz: https://doaj.org/article/2dfcaf8d6ead4e62adcc1a8645a9dcd9

Zobrazit plný text záznamu

Akademický článek

VAPC, an human endogenous inhibitor for hepatitis C virus (HCV) infection, is intrinsically unstructured but forms a 'fuzzy complex' with HCV NS5B.

Autor: Shaveta Goyal, Garvita Gupta, Haina Qin, Megha Haridas Upadya, Yee Joo Tan, Vincent T K Chow, Jianxing Song

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40341 (2012)

Nearly 200 million people are infected by hepatitis C virus (HCV) worldwide. For replicating the HCV genome, the membrane-associated machinery needs to be formed by both HCV non-structural proteins (including NS5B) and human host factors such as VAPB

Externí odkaz: https://doaj.org/article/d372bea7774d442ab91474e2d17397a7

Zobrazit plný text záznamu

Akademický článek

Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations.

Autor: Shixiong Lua, Haina Qin, Liangzhong Lim, Jiahai Shi, Garvita Gupta, Jianxing Song

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27072 (2011)

T46I is the second mutation on the hVAPB MSP domain which was recently identified from non-Brazilian kindred to cause a familial amyotrophic lateral sclerosis (ALS). Here using CD, NMR and molecular dynamics (MD) simulations, we characterized the str

Externí odkaz: https://doaj.org/article/4b8dfde537b44338b7145b5522118298

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání