Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Garth Rapeport"'
Autor:
Lindsey Cass, Alison Murray, Amanda Davis, Kathy Woodward, Muna Albayaty, Kazuhiro Ito, Pete Strong, John Ayrton, Charlie Brindley, Jayne Prosser, John Murray, Eddie French, Phillip Haywood, Christopher Wallis, Garth Rapeport
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 1, Pp n/a-n/a (2021)
Abstract PC945 is a novel antifungal triazole formulated for nebulized delivery to treat lung Aspergillus infections. Pharmacokinetic and safety profiles from nonclinical studies and clinical trials in healthy subjects, and subjects with mild asthma
Externí odkaz:
https://doaj.org/article/0bd3a72ad5fc4f21b9cbc8db0aa32460
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 205:1271-1280
A dramatic global reduction in the incidence of common seasonal respiratory viral infections has resulted from measures to limit the transmission of SARS2-Cov-19 during the pandemic . This has been accompanied by falls reaching 50% internationally in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6448d9bf756ec9c6feee81c50182096e
https://doi.org/10.1164/rccm.202110-2389ci
https://doi.org/10.1164/rccm.202110-2389ci
Autor:
Anthony Gilbert, Helen McShane, Christopher Chiu, Andrew Catchpole, Emma Smith, Garth Rapeport
Publikováno v:
New England Journal of Medicine. 385:961-964
SARS-CoV-2 Human Challenge Studies While commentators have made theoretical arguments for and against SARS-CoV-2 challenge studies, a consortium of academics, industry collaborators, and the Britis...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791b266944f2f76d3715866c8220d78c
https://doi.org/10.1056/nejmp2106970
https://doi.org/10.1056/nejmp2106970
Autor:
Matthew Coates, Alison Murray, Kathy Woodward, Vicky Wheeler, Meabh McCurdy, Lindsey Cass, Kazuhiro Ito, Bryan Murray, Amanda Davis, Julie Mori, Elizabeth A. Meals, Garth Rapeport, Charlie Brindley, John P. DeVincenzo, Pete Strong, Leah Daly
Publikováno v:
The Journal of Infectious Diseases. 225:2087-2096
Background PC786 is a nebulized nonnucleoside respiratory syncytial virus (RSV) polymerase inhibitor designed to treat RSV, which replicates in the superficial layer of epithelial cells lining the airways. Methods Fifty-six healthy volunteers inocula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6525cc6578189ec94d7fed43e5587f
https://doi.org/10.1093/infdis/jiaa716
https://doi.org/10.1093/infdis/jiaa716
Autor:
Ben Killingley, Alex Mann, Mariya Kalinova, Alison Boyers, Niluka Goonawardane, Jie Zhou, Kate Lindsell, Samanjit S. Hare, Jonathan Brown, Rebecca Frise, Emma Smith, Claire Hopkins, Nicolas Noulin, Brandon Londt, Tom Wilkinson, Stephen Harden, Helen McShane, Mark Baillet, Anthony Gilbert, Michael Jacobs, Christine Charman, Priya Mande, Jonathan S. Nguyen-Van-Tam, Malcolm G. Semple, Robert C. Read, Neil M. Ferguson, Peter J. Openshaw, Garth Rapeport, Wendy S. Barclay, Andrew P. Catchpole, Christopher Chiu
To establish a novel SARS-CoV-2 human challenge model, 36 volunteers aged 18-29 years without evidence of previous infection or vaccination were inoculated with 10 TCID50 of a wild-type virus (SARS-CoV-2/human/GBR/484861/2020) intranasally. Two parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4acff7b7df2c4e91fd494a0e42410910
https://doi.org/10.21203/rs.3.rs-1121993/v1
https://doi.org/10.21203/rs.3.rs-1121993/v1
Autor:
Ben Killingley, Alex J. Mann, Mariya Kalinova, Alison Boyers, Niluka Goonawardane, Jie Zhou, Kate Lindsell, Samanjit S. Hare, Jonathan Brown, Rebecca Frise, Emma Smith, Claire Hopkins, Nicolas Noulin, Brandon Löndt, Tom Wilkinson, Stephen Harden, Helen McShane, Mark Baillet, Anthony Gilbert, Michael Jacobs, Christine Charman, Priya Mande, Jonathan S. Nguyen-Van-Tam, Malcolm G. Semple, Robert C. Read, Neil M. Ferguson, Peter J. Openshaw, Garth Rapeport, Wendy S. Barclay, Andrew P. Catchpole, Christopher Chiu
Publikováno v:
NATURE MEDICINE
Since its emergence in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused hundreds of millions of cases and continues to circulate globally. To establish a novel SARS-CoV-2 human challenge model that enables controlled inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19770fcfa2186270555032383616651
https://pubmed.ncbi.nlm.nih.gov/35610124
https://pubmed.ncbi.nlm.nih.gov/35610124
Publikováno v:
The New England journal of medicine. 385(18)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbbc4f3522ebe42ab5713f047b64bafc
https://pubmed.ncbi.nlm.nih.gov/34587380
https://pubmed.ncbi.nlm.nih.gov/34587380
Autor:
Garth Rapeport, Jacques F. Meis, Yuki Nishimoto, Thomas Colley, Alexandre Alanio, Stéphane Bretagne, Kazuhiro Ito, Pete Strong, Anuradha Chowdhary, Genki Kimura, Leah Daly, Yasuo Kizawa, Cheshta Sharma, Takahiro Nakaoki
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives The growing emergence of azole-resistant Aspergillus fumigatus strains worldwide is a major concern for current systemic antifungal treatment. Here we report antifungal activities of a novel inhaled triazole, PC1244, against a collection o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b3282e4fc5c706fe37474d652d4c54
http://europepmc.org/articles/PMC6753496
http://europepmc.org/articles/PMC6753496
Autor:
John Ayrton, Muna Albayaty, Eddie French, Alison Murray, Charlie Brindley, Kathy Woodward, Lindsey Cass, Jayne Prosser, Pete Strong, Haywood Phillip A, Ito Kazuhiro, Christopher Wallis, John Murray, Amanda Davis, Garth Rapeport
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 1, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
PC945 is a novel antifungal triazole formulated for nebulized delivery to treat lung Aspergillus infections. Pharmacokinetic and safety profiles from nonclinical studies and clinical trials in healthy subjects, and subjects with mild asthma were char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6c303576ebff497c68f011ba5552aa
https://doaj.org/article/0bd3a72ad5fc4f21b9cbc8db0aa32460
https://doaj.org/article/0bd3a72ad5fc4f21b9cbc8db0aa32460
Publikováno v:
Clinical and Translational Allergy, Vol 10, Iss 1, Pp 1-15 (2020)
Clinical and Translational Allergy
Clinical and Translational Allergy
In patients with asthma, the inhalation of elevated amounts of fungal spores and hyphae may precipitate the onset of asthma or worsen control to the extent of being life-threatening. Sensitisation to fungi, especially Aspergillus fumigatus, is found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21765529427baf129212e3c6d7e19f83
https://doi.org/10.1186/s13601-020-00353-8
https://doi.org/10.1186/s13601-020-00353-8