Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Garth L, Warnock"'
Autor:
Queenie Hui, Ali Asadi, Yoo Jin Park, Timothy J. Kieffer, Ziliang Ao, Garth L. Warnock, Lucy Marzban
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 833-844 (2017)
Objectives: β-cell dysfunction and apoptosis associated with islet inflammation play a key role in the pathogenesis of type 2 diabetes (T2D). Growing evidence suggests that islet amyloid, formed by aggregation of human islet amyloid polypeptide (hIA
Externí odkaz:
https://doaj.org/article/6960a9c74b2c430bbfa4556630d36243
Autor:
Yun Zhang, Garth L Warnock, Ziliang Ao, Yoo Jin Park, Nooshin Safikhan, Aziz Ghahary, Lucy Marzban
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193184 (2018)
Amyloid formation in the pancreatic islets due to aggregation of human islet amyloid polypeptide (hIAPP) contributes to reduced β-cell mass and function in type 2 diabetes (T2D) and islet transplantation. Protein kinase B (PKB) signaling plays a key
Externí odkaz:
https://doaj.org/article/6f94636cc45e4f40866eafd23967be66
Autor:
Reza B Jalili, Yun Zhang, Azadeh Hosseini-Tabatabaei, Ruhangiz T Kilani, Mohsen Khosravi Maharlooei, Yunyuan Li, Sanam Salimi Elizei, Garth L Warnock, Aziz Ghahary
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146970 (2016)
Type 1 diabetes (T1D) results from autoimmune destruction of insulin producing β cells of the pancreatic islets. Curbing autoimmunity at the initiation of T1D can result in recovery of residual β cells and consequently remission of diabetes. Here w
Externí odkaz:
https://doaj.org/article/523cc6162cc74e73b878e51c9b5686ee
Autor:
Tianshu Angela Ji, Huai-Hsuan Clare Chiu, Dan Cojocaru, Geoffrey K. Blair, Karan D'Souza, Garth L. Warnock
Publikováno v:
Journal of Surgical Education. 77:323-328
OBJECTIVE A lack of structure and communication in physician shadowing experiences may prevent medical students from accruing its potential benefits. In this study, we evaluated the use of an objectives-based surgical shadowing teacher-learner contra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6b0ac6a1fff6f70f30a6653613a2b2
https://doi.org/10.1016/j.jsurg.2019.09.013
https://doi.org/10.1016/j.jsurg.2019.09.013
Autor:
Xiaojie Wang, Jianqiang Hao, Gigi Leung, Trisia Breitkopf, Eddy Wang, Nicole Kwong, Noushin Akhoundsadegh, Garth L. Warnock, Jerry Shapiro, Kevin J. McElwee
Publikováno v:
Journal of Immunology Research, Vol 2015 (2015)
Immunosuppressive drugs successfully prevent rejection of islet allografts in the treatment of type I diabetes. However, the drugs also suppress systemic immunity increasing the risk of opportunistic infection and cancer development in allograft reci
Externí odkaz:
https://doaj.org/article/4cb22f23293c48279275f5e3bad6cc09
Autor:
Xiaojie Wang, Jianqiang Hao, Daniel L. Metzger, Alice Mui, Ziliang Ao, C. Bruce Verchere, Lieping Chen, Dawei Ou, Garth L. Warnock M.D.
Publikováno v:
Cell Transplantation, Vol 21 (2012)
Negative cosignaling molecules play an important role in regulating T-cell responses to alloantigen stimulation. We recently reported that adenoviral-mediated transduction of islet allografts with B7-H4 inhibits allograft rejection. In this study, we
Externí odkaz:
https://doaj.org/article/b001d0aca263466fa58cf315a44f5214
Autor:
Xiaojie Wang, Jianqiang Hao, Daniel L Metzger, Ziliang Ao, Lieping Chen, Dawei Ou, C Bruce Verchere, Alice Mui, Garth L Warnock
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e28232 (2012)
B7-H4 is a newly identified B7 homolog that plays an important role in maintaining T-cell homeostasis by inhibiting T-cell proliferation and lymphokine-secretion. In this study, we investigated the signal transduction pathways inhibited by B7-H4 enga
Externí odkaz:
https://doaj.org/article/4aa795a5ba164a0496255f196a8c99a2
Publikováno v:
International Journal of Endocrinology, Vol 2012 (2012)
Islet cell transplantation offers a potential cure for type 1 diabetes, but it is challenged by insufficient donor tissue and side effects of current immunosuppressive drugs. Therefore, alternative sources of insulin-producing cells and isletfriendly
Externí odkaz:
https://doaj.org/article/00b667b493bb4db7b7d57316e53182d0
Autor:
David M. Thompson, Timothy J. Kieffer, Peter T. W. Kim, Laura Cook, Adam Ramzy, Jackson Loyal, Rosa Garcia, Garth L. Warnock, Kirsten A. Ward-Hartstonge, Sabine Ivison, Megan K. Levings
Publikováno v:
Cell Stem Cell. 28:2047-2061.e5
Summary An open-label, first-in-human phase 1/2 study is being conducted to evaluate the safety and efficacy of pancreatic endoderm cells (PECs) implanted in non-immunoprotective macroencapsulation devices for the treatment of type 1 diabetes. We rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e72dcede33925be850ff8286977a494
https://doi.org/10.1016/j.stem.2021.10.003
https://doi.org/10.1016/j.stem.2021.10.003
Autor:
Xiaojie Wang, Jianqiang Hao, Daniel L. Metzger, Ziliang Ao, Mark Meloche, C. Bruce Verchere, Lieping Chen, Dawei Ou, Alice Mui, Garth L. Warnock
Publikováno v:
Journal of Transplantation, Vol 2011 (2011)
Type 1 diabetes (T1D) is a chronic autoimmune disease and characterized by absolute insulin deficiency. β-cell replacement by islet cell transplantation has been established as a feasible treatment option for T1D. The two main obstacles after islet
Externí odkaz:
https://doaj.org/article/a65e6589fd094c0ab878c5d910be7c30