Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Garth J S Cooper"'
Autor:
Ivana R Sequeira, Wilson Yip, Louise W Lu, Yannan Jiang, Rinki Murphy, Lindsay D Plank, Garth J S Cooper, Carl N Peters, Benjamin S Aribsala, Kieren G Hollingsworth, Sally D Poppitt
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279085 (2022)
ObjectiveWhile there is an emerging role of pancreatic fat in the aetiology of type 2 diabetes mellitus (T2DM), its impact on the associated decrease in insulin secretion remains controversial. We aimed to determine whether pancreatic fat negatively
Externí odkaz:
https://doaj.org/article/80b107414846425aa4d93915af84dce6
Autor:
Elahe Kia, Brett Wagner Mackenzie, Danielle Middleton, Anna Lau, David W Waite, Gillian Lewis, Yih-Kai Chan, Marta Silvestre, Garth J S Cooper, Sally D Poppitt, Michael W Taylor
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163666 (2016)
In studies of the human microbiome, faecal samples are frequently used as a non-invasive proxy for the study of the intestinal microbiota. To obtain reliable insights, the need for bacterial DNA of high quality and integrity following appropriate fae
Externí odkaz:
https://doaj.org/article/1c2f71e73c374253b8d9dce6088af6f9
Autor:
Simon G Anderson, Warwick B Dunn, Moulinath Banerjee, Marie Brown, David I Broadhurst, Royston Goodacre, Garth J S Cooper, Douglas B Kell, J Kennedy Cruickshank
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e103217 (2014)
Blood-vessel dysfunction arises before overt hyperglycemia in type-2 diabetes (T2DM). We hypothesised that a metabolomic approach might identify metabolites/pathways perturbed in this pre-hyperglycemic phase. To test this hypothesis and for specific
Externí odkaz:
https://doaj.org/article/65ef4c2d62664192ae8273490693be94
Autor:
Janice B B Lam, Kim H M Chow, Aimin Xu, Karen S L Lam, Jing Liu, Nai-Sum Wong, Randall T Moon, Peter R Shepherd, Garth J S Cooper, Yu Wang
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4968 (2009)
Adiponectin is an adipokine possessing beneficial effects on obesity-related medical complications. A negative association of adiponectin levels with breast cancer development has been demonstrated. However, the precise role of adiponectin deficiency
Externí odkaz:
https://doaj.org/article/03f22a636964446e86d1d3bce8de7668
Pan-cerebral sodium elevations in vascular dementia: Evidence for disturbed brain-sodium homeostasis
Autor:
Sasha A. Philbert, Jingshu Xu, Stephanie J. Church, Richard D. Unwin, Federico Roncaroli, Garth J. S. Cooper
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Vascular dementia (VaD) is the second most common cause of cognitive impairment amongst the elderly. However, there are no known disease-modifying therapies for VaD, probably due to incomplete understanding of the molecular basis of the disease. Desp
Externí odkaz:
https://doaj.org/article/55008665761749babd1effdcee0407a7
Autor:
Melissa Scholefield, Stephanie J. Church, George Taylor, David Knight, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
npj Parkinson's Disease. 9
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, most commonly characterised by motor dysfunction, but also with a high prevalence of cognitive decline in the decades following diagnosis—a condition known as Parkinso
Autor:
Agnese, Padula, Raffaella, Petruzzelli, Sasha A, Philbert, Stephanie J, Church, Federica, Esposito, Severo, Campione, Marcello, Monti, Filomena, Capolongo, Claudia, Perna, Edoardo, Nusco, Hartmut H, Schmidt, Alberto, Auricchio, Garth J S, Cooper, Roman, Polishchuk, Pasquale, Piccolo
Publikováno v:
Molecular therapy. Methodsclinical development. 26
Wilson disease (WD) is a genetic disorder of copper homeostasis, caused by deficiency of the copper transporter ATP7B. Gene therapy with recombinant adeno-associated vectors (AAV) holds promises for WD treatment. However, the full-length human
Autor:
Zhanxuan E. Wu, Marlena C. Kruger, Garth J. S. Cooper, Ivana R. Sequeira, Anne‐Thea McGill, Sally D. Poppitt, Karl Fraser
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(7)
Untargeted metabolomics of blood samples has become widely applied to study metabolic alterations underpinning disease and to identify biomarkers. However, understanding the relevance of a blood metabolite marker can be challenging if it is unknown w
Autor:
Ivana R, Sequeira, Wilson C, Yip, Louise W W, Lu, Yannan, Jiang, Rinki, Murphy, Lindsay D, Plank, Garth J S, Cooper, Carl N, Peters, Jun, Lu, Kieren G, Hollingsworth, Sally D, Poppitt
Publikováno v:
Frontiers in Physiology. 13
ObjectivePrevalence of type 2 diabetes (T2D) is disproportionately higher in younger outwardly lean Asian Chinese compared to matched Caucasians. Susceptibility to T2D is hypothesised due to dysfunctional adipose tissue expansion resulting in adverse
Autor:
Sasha A. Philbert, Jingshu Xu, Melissa Scholefield, Stephanie J. Church, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Philbert, S, Cooper, G JS, Xu, J, Unwin, R, Church, S & Scholefield, M 2022, ' Contrasting Sodium and Potassium Perturbations in the Hippocampus Indicate Potential Na +/K +-ATPase Dysfunction in Vascular Dementia ', Frontiers in aging neuroscience, vol. 14, 822787, pp. 822787 . https://doi.org/10.3389/fnagi.2022.822787
Frontiers in Aging Neuroscience, Vol 14 (2022)
Frontiers in Aging Neuroscience, Vol 14 (2022)
Vascular dementia (VaD) is thought to be the second most common cause of age-related dementia amongst the elderly. However, at present, there are no available disease-modifying therapies for VaD, probably due to insufficient understanding about the m