Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Garth Blackler"'
Autor:
Garth Blackler, Yue Lai-Zhao, Joseph Klapak, Holly T. Philpott, Kyle K. Pitchers, Andrew R. Maher, Benoit Fiset, Logan A. Walsh, Elizabeth R. Gillies, C. Thomas Appleton
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Background Pain from osteoarthritis (OA) is one of the top causes of disability worldwide, but effective treatment is lacking. Nociceptive factors are released by activated synovial macrophages in OA, but depletion of synovial macrophages pa
Externí odkaz:
https://doaj.org/article/0940f57f8f3a45eebcbb4ee9caf19d39
Autor:
Garth Blackler, James Akingbasote, Ewa Cairns, Christopher Howlett, Patti Kiser, Lillian Barra
Publikováno v:
Journal of Translational Autoimmunity, Vol 7, Iss , Pp 100203- (2023)
Objectives: HLA-DRB1 is associated with an increased risk of cardiovascular disease in patients with rheumatoid arthritis (RA). This study aimed to determine the effect of HLA-DRB1 on atherosclerotic cardiovascular disease (ASCVD) using a novel mouse
Externí odkaz:
https://doaj.org/article/2a8cfe2531d14841b278a8baeca4ba43
Publikováno v:
Journal of Translational Autoimmunity, Vol 3, Iss , Pp 100053- (2020)
Rheumatoid Arthritis (RA) is more common and severe in women compared to men. Both women and men with RA express autoantibodies to post-translationally modified antigens, including citrullinated and homocitrullinated proteins or peptides. These autoa
Externí odkaz:
https://doaj.org/article/88f5c1d152fa46019ec103d333f76282
Autor:
Ermina Hadzic, Garth Blackler, Holly Dupuis, Stephen James Renaud, Christopher Thomas Appleton, Frank Beier
Publikováno v:
Applied Sciences, Vol 11, Iss 15, p 7118 (2021)
Post-traumatic osteoarthritis (PTOA) is a degenerative joint disease, leading to articular cartilage breakdown, osteophyte formation, and synovitis, caused by an initial joint trauma. Pro-inflammatory cytokines increase catabolic activity and may per
Externí odkaz:
https://doaj.org/article/76532e77b6d1435190f7c715cefe90f5
Autor:
Holly T. Philpott, Garth Blackler, Joseph Daniel Klapak, Kyle K. Pitchers, Madison Tomlinson, Niall Smith, Jaclyn Viehweger, Joseph U. Umoh, David W. Holdsworth, Tristan Maerz, Christopher Thomas Appleton
Publikováno v:
Journal of Orthopaedic Research.
Autor:
Garth Blackler, Yue Lai-Zhao, Joseph Klapak, Holly T. Philpott, Kyle K. Pitchers, Andrew R. Maher, Benoit Fiset, Logan A. Walsh, Elizabeth R. Gillies, C. Thomas Appleton
It has been suggested that synovial macrophages mediate nociceptive signals in knee osteoarthritis (OA) but the underlying mechanisms are unknown. Our objectives were to investigate the role of synovial macrophages and their activation via signal tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ba0f4919d490e3e7cfb1e42491d725c
https://doi.org/10.1101/2023.04.25.538261
https://doi.org/10.1101/2023.04.25.538261
Autor:
Frank Beier, Stephen J. Renaud, Ermina Hadzic, Holly Dupuis, Garth Blackler, Christopher Thomas Appleton
Publikováno v:
Bone and Joint Institute
Applied Sciences
Volume 11
Issue 15
Applied Sciences, Vol 11, Iss 7118, p 7118 (2021)
Applied Sciences
Volume 11
Issue 15
Applied Sciences, Vol 11, Iss 7118, p 7118 (2021)
Post-traumatic Osteoarthritis (PTOA) is a degenerative joint disease, leading to articular cartilage breakdown, osteophyte formation, and synovitis, caused by an initial joint trauma. Pro-inflammatory cytokines increase catabolic activity and may per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4289da4a11cc6d9fbba31a4d27349d53
https://doi.org/10.1101/2021.04.15.440032
https://doi.org/10.1101/2021.04.15.440032
Publikováno v:
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity, Vol 3, Iss, Pp 100053-(2020)
Bone and Joint Institute
Journal of Translational Autoimmunity, Vol 3, Iss, Pp 100053-(2020)
Bone and Joint Institute
Rheumatoid Arthritis (RA) is more common and severe in women compared to men. Both women and men with RA express autoantibodies to post-translationally modified antigens, including citrullinated and homocitrullinated proteins or peptides. These autoa
Autor:
Jonathan Hu, Dave Nagpal, Rajesh Abraham Jacob, Jimmy D. Dikeakos, James Akingbasote, Angela M. Vrieze, Lillian Barra, Neha Sharma, Charles Yin, Garth Blackler, Bryan Heit, Emily N. Pawlak
Publikováno v:
Journal of the American College of Cardiology. 75:2228
Atherosclerosis is an inflammatory disease involving formation of lipid-rich lesions within the arteries. Macrophages clear apoptotic cells that accumulate within these lesions. Defective apoptotic cell clearance is a hallmark of advanced atheroscler