Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Garry Weems"'
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Pharmacokinetic results at Day 29, by cohort (median [range])
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761803ef4b2434e7ff2418ba535f26e5
https://doi.org/10.1158/1078-0432.22469712
https://doi.org/10.1158/1078-0432.22469712
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
LYC-55716 toxicology thermometer plot indicating a pharmacologically active exposure of 18.6μg·h/mL, based on the upregulation of target genes in mouse thymus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e54a85ba157ea25ab3981c8cf5782f9
https://doi.org/10.1158/1078-0432.22469721.v1
https://doi.org/10.1158/1078-0432.22469721.v1
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Baseline RORgt (RORC2) expression is variable from patient to patient.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a017a95fe20e70d01be7ff951de0f44d
https://doi.org/10.1158/1078-0432.22469715.v1
https://doi.org/10.1158/1078-0432.22469715.v1
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Purpose:Transcription factor retinoic acid receptor–related orphan receptor γ (RORγ) regulates type 17 effector T-cell differentiation and function and is key to immune cell regulation. Synthetic RORγ agonists modulate immune cell gene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b94f77cf3892037b3e87257e1cdc429
https://doi.org/10.1158/1078-0432.c.6527316.v1
https://doi.org/10.1158/1078-0432.c.6527316.v1
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Post-treatment changes in IL-17A and pharmacokinetic profiles for Cohort 4a (600 mg QD) and Cohort 4b (300 mg BID). D, day; PD, pharmacodynamics; PK, pharmacokinetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f39aaacac1168b73f2c09557c63cdd5
https://doi.org/10.1158/1078-0432.22469718.v1
https://doi.org/10.1158/1078-0432.22469718.v1
Autor:
H. Jeffrey Wilkins, Marshall Schreeder, Xiao Hu, Laura Carter, Garry Weems, John Nemunaitis, John Sarantopoulos, Erika P. Hamilton, Judy S. Wang, Devalingam Mahalingam
Fold induction over Day 1 pre-dose.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018d87e7dfac7d80c8c4c814cce840ab
https://doi.org/10.1158/1078-0432.22469709.v1
https://doi.org/10.1158/1078-0432.22469709.v1
Autor:
Jérôme Alexandre, Carmen Kahatt, Frédérique Bertheault-Cvitkovic, Sandrine Faivre, Stephen Shibata, Werner Hilgers, François Goldwasser, François Lokiec, Eric Raymond, Garry Weems, Ajit Shah, John MacDonald
Publikováno v:
Investigational New Drugs; Oct2007, Vol. 25 Issue 5, p453-462, 10p
Autor:
Werner Hilgers, Sandrine Faivre, Stéphanie Chieze, Jérôme Alexandre, François Lokiec, François Goldwasser, Eric Raymond, Carmen Kahatt, Abdelkrim Taamma, Garry Weems, John MacDonald, Jean-Louis Misset, Esteban Cvitkovic
Publikováno v:
Investigational New Drugs; Jul2006, Vol. 24 Issue 4, p311-319, 9p