Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Garry Southan"'
Autor:
Satoshi Fukuda, Yosuke Niimi, Yasutaka Hirasawa, Ennert R. Manyeza, C. Edwin Garner, Garry Southan, Andrew L. Salzman, Donald S. Prough, Perenlei Enkhbaatar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract In sepsis, microvascular hyperpermeability caused by oxidative/nitrosative stress (O&NS) plays an important role in tissue edema leading to multi-organ dysfunctions and increased mortality. We hypothesized that a novel compound R-107, a modu
Externí odkaz:
https://doaj.org/article/0a205f198d544ea58822c974d20c9099
Autor:
Alexander Nivorozhkin, Kevin Desisto, Garry Southan, Prakash Jagtap, William Williams, and Andrew L. Salzman, Nelson Landrau, Csaba Szabó, Aloka Roy, Erkan Baloglu
Publikováno v:
Organic Letters. 7:1753-1756
[reaction: see text] The synthesis of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-ones from the base-promoted condensation reaction of homophthalic anhydride and 2-(bromomethyl)-benzonitrile and a convenient method for the synthesis of indolo[3,2-c]is
Publikováno v:
Tetrahedron Letters. 50:2057-2059
A highly efficient and clean method has been developed for the synthesis of 3-oxoindeno[2,1-c]isocoumarins and 3-oxoindeno[2,1-c]isoquinolinones from 4-phenyl-3-isocoumarincarboxylic acids and 4-phenyl-3-isoquinolinonecarboxylic acids, respectively.
Publikováno v:
Proceedings of the National Academy of Sciences. 91:12472-12476
Enhanced formation of nitric oxide (NO) by both the constitutive and the inducible isoforms of NO synthase (NOS) has been implicated in the pathophysiology of a variety of diseases, including circulatory shock. Non-isoform-selective inhibition of NO
Publikováno v:
ChemInform. 40
A highly efficient and clean method has been developed for the synthesis of 3-oxoindeno[2,1-c]isocoumarins and 3-oxoindeno[2,1-c]isoquinolinones from 4-phenyl-3-isocoumarincarboxylic acids and 4-phenyl-3-isoquinolinonecarboxylic acids, respectively.
Autor:
William Williams, Walter J. Koch, Xiangying Jiao, Bernard L. Lopez, Kumar Sharma, Garry Southan, Erhe Gao, Wayne Bond Lau, Theodore A. Christopher, Yuexing Yuan, Ling Tao, Xin L. Ma, Satish P. RamachandraRao
Publikováno v:
Circulation. 114(13)
Background— Intracellular proteins involved in oxidative stress and apoptosis are nitrated in diseased tissues but not in normal tissues; definitive evidence to support a causative link between a specific protein that is nitratively modified with t
Autor:
Csaba Szabó, Jon G. Mabley, Siya Ram, Erkan Baloglu, Andrew L. Salzman, Anita Marton, Prakash Jagtap, Garry Southan
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(1)
A series of novel 4-(N-acyl)-2,3-dihydro-1H-isoindol-1-ones have been prepared from methyl-3-nitro-2-methylbenzoate and linked through various spacers to the adenosine derivatives 11 and 12. We found that potent inhibition of poly(ADP-ribose)polymera
Autor:
Pavel Martásek, Garry Southan, Huiying Li, Bettie Sue Siler Masters, Chander Raman, Thomas L. Poulos
Publikováno v:
Biochemistry. 40(45)
Nitric oxide is generated under normal and pathophysiological conditions by three distinct isoforms of nitric oxide synthase (NOS). A small-molecule inhibitor of NOS (3-Br-7-nitroindazole, 7-NIBr) is profoundly neuroprotective in mouse models of stro
Publikováno v:
The Haemodynamic Effects of Nitric Oxide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78be053caaf5d30d5980ff60be4e6bbf
https://doi.org/10.1142/9781848160781_0007
https://doi.org/10.1142/9781848160781_0007
Publikováno v:
European journal of pharmacology. 291(3)
We evaluated the ability of simple alkyl amidines to inhibit the activity of the inducible isoform of nitric oxide (NO) synthase in vitro. In immunostimulated J774 macrophages, 2-iminopiperidine (EC 50 = 10 μ M) and butyramidine (EC 50 = 60 μ M) we