Zobrazeno 1 - 10
of 417
pro vyhledávání: '"Garry R, Buettner"'
Autor:
Kellie L. Bodeker, Brian J. Smith, Daniel J. Berg, Chandrikha Chandrasekharan, Saima Sharif, Naomi Fei, Sandy Vollstedt, Heather Brown, Meghan Chandler, Amanda Lorack, Stacy McMichael, Jared Wulfekuhle, Brett A. Wagner, Garry R. Buettner, Bryan G. Allen, Joseph M. Caster, Barbara Dion, Mandana Kamgar, John M. Buatti, Joseph J. Cullen
Publikováno v:
Redox Biology, Vol 77, Iss , Pp 103375- (2024)
Background: Patients with metastatic pancreatic ductal adenocarcinoma (PDAC) have poor 5-year survival. Pharmacological ascorbate (P-AscH-, high dose, intravenous, vitamin C) has shown promise as an adjunct to chemotherapy. We hypothesized adding P-A
Externí odkaz:
https://doaj.org/article/7a718d95f6c446c69fd37ed4334b67e1
Autor:
Madeline R. Hines, Piedad C. Gomez-Contreras, Suryamin Liman, Alexandria M. Wilson, Kevin J. Lu, Jaycie A. O'Neill, Jacob S. Fisher, Douglas C. Fredericks, Brett A. Wagner, Garry R. Buettner, Holly Van Remmen, Mitchell C. Coleman
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103306- (2024)
In orthopedic research, many studies have applied vitamin E as a protective antioxidant or used tert-butyl hydroperoxide to induce oxidative injury to chondrocytes. These studies often support the hypothesis that joint pathology causes oxidative stre
Externí odkaz:
https://doaj.org/article/817362ea08d7463e9414d0fd6087f442
Publikováno v:
Advances in Redox Research, Vol 9, Iss , Pp 100079- (2023)
Nitric oxide (NO•) generated by nitric oxide synthases is involved in many physiological and pathophysiological processes. However, non-enzymatic formation of NO• also occurs in vivo. Here we investigated the production of NO• from nitrite, as
Externí odkaz:
https://doaj.org/article/7c7bece3bd724fa389e1838f0d403ead
Autor:
Brett A. Wagner, Garry R. Buettner
Publikováno v:
Advances in Redox Research, Vol 9, Iss , Pp 100077- (2023)
Ascorbate (vitamin C) can rapidly oxidize in many near-neutral pH, aqueous solutions. We report on the stability of ascorbate solutions prepared for infusion into patients using standard pharmacy protocols, for example, 75 g of ascorbate/L in water f
Externí odkaz:
https://doaj.org/article/99d02de7caf6468793d9d1c84a31aa41
Autor:
Gloria Y. Chen, Brianne R. O’Leary, Juan Du, Rory S. Carroll, Garett J. Steers, Garry R. Buettner, Joseph J. Cullen
Publikováno v:
Antioxidants, Vol 13, Iss 3, p 361 (2024)
The toxicity of ionizing radiation limits its effectiveness in the treatment of pancreatic ductal adenocarcinoma. Pharmacologic ascorbate (P-AscH−) has been shown to radiosensitize pancreatic cancer cells while simultaneously radioprotecting normal
Externí odkaz:
https://doaj.org/article/d50be425446b432099130382021777a4
Autor:
Juan Du, Amanda N. Pope, Brianne R. O’Leary, Brett A. Wagner, Prabhat C. Goswami, Garry R. Buettner, Joseph J. Cullen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract At pharmacological levels, ascorbate (P-AscH-) acts as a pro-oxidant by generating H2O2, depleting ATP in sensitive cells leading to cell death. The aim of this study was to determine the role of ATP production by oxidative phosphorylation o
Externí odkaz:
https://doaj.org/article/c43e8748fa3d45c9940de066f4152d51
Autor:
Khaliunaa Bayanbold, Mekhla Singhania, Melissa A. Fath, Charles C. Searby, Jeffrey M. Stolwijk, John B. Henrich, Casey F. Pulliam, Joshua D. Schoenfeld, Kranti A. Mapuskar, Sei Sho, Joseph M. Caster, Bryan G. Allen, Garry R. Buettner, Maria Spies, Prabhat C. Goswami, Michael S. Petronek, Douglas R. Spitz
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 2005 (2023)
The intracellular redox-active labile iron pool (LIP) is weakly chelated and available for integration into the iron metalloproteins that are involved in diverse cellular processes, including cancer cell-specific metabolic oxidative stress. Abnormal
Externí odkaz:
https://doaj.org/article/528679c8946943c59f5691686a352e09
Autor:
Garett J. Steers, Brianne R. O’Leary, Juan Du, Brett A. Wagner, Rory S. Carroll, Frederick E. Domann, Prabhat C. Goswami, Garry R. Buettner, Joseph J. Cullen
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1683 (2023)
Recent studies have demonstrated an important role for vitamin C in the epigenetic regulation of cancer-related genes via DNA demethylation by the ten-eleven translocation (TET) methylcytosine dioxygenase enzymes. DNA methyltransferase (DNMT) reverse
Externí odkaz:
https://doaj.org/article/43fcb3ed3d244d5f89e306ce3c3698cf
Autor:
Muhammad Furqan, Taher Abu-Hejleh, Laura M. Stephens, Stacey M. Hartwig, Sarah L. Mott, Casey F. Pulliam, Michael Petronek, John B. Henrich, Melissa A. Fath, Jon C. Houtman, Steven M. Varga, Kellie L. Bodeker, Aaron D. Bossler, Andrew M. Bellizzi, Jun Zhang, Varun Monga, Hariharasudan Mani, Marina Ivanovic, Brian J. Smith, Margaret M. Byrne, William Zeitler, Brett A. Wagner, Garry R. Buettner, Joseph J. Cullen, John M. Buatti, Douglas R. Spitz, Bryan G. Allen
Publikováno v:
Redox Biology, Vol 53, Iss , Pp 102318- (2022)
Purpose: Platinum-based chemotherapy with or without immunotherapy is the mainstay of treatment for advanced stage non-small cell lung cancer (NSCLC) lacking a molecular driver alteration. Pre-clinical studies have reported that pharmacological ascor
Externí odkaz:
https://doaj.org/article/3029ad560b984a928c853c72d0650fca
Autor:
Jeffrey M. Stolwijk, Jonathan A. Stefely, Mike T. Veling, Thomas J. van ‘t Erve, Brett A. Wagner, Thomas J. Raife, Garry R. Buettner
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102073- (2021)
The antioxidant function of the phospholipid hydroperoxide glutathione peroxidase (GPx4) is vital for the homeostasis of many cell types, from neoplastic cells to normal erythroid precursors. However, some functional proteins in erythroid precursors
Externí odkaz:
https://doaj.org/article/4e3644b66d1243489f48434d1b9c88ec