Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Garry P. Duffy"'
Autor:
Chuan-en Lu, Ruth E. Levey, Giulio Ghersi, Nathan Schueller, Simone Liebscher, Shannon L. Layland, Katja Schenke-Layland, Garry P. Duffy, Julia Marzi
Publikováno v:
Materials Today Bio, Vol 21, Iss , Pp 100696- (2023)
Understanding the immune system's foreign body response (FBR) is essential when developing and validating a biomaterial. Macrophage activation and proliferation are critical events in FBR that can determine the material's biocompatibility and fate in
Externí odkaz:
https://doaj.org/article/d39ee9231f594df4b253ea19d5d67d03
Autor:
William Whyte, Debkalpa Goswami, Sophie X. Wang, Yiling Fan, Niamh A. Ward, Ruth E. Levey, Rachel Beatty, Scott T. Robinson, Declan Sheppard, Raymond O’Connor, David S. Monahan, Lesley Trask, Keegan L. Mendez, Claudia E. Varela, Markus A. Horvath, Robert Wylie, Joanne O’Dwyer, Daniel A. Domingo-Lopez, Arielle S. Rothman, Garry P. Duffy, Eimear B. Dolan, Ellen T. Roche
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Drug delivery implants suffer from diminished release profiles due to fibrous capsule formation over time. Here, the authors use soft robotic actuation to modulate the immune response of the host to maintain drug delivery over the longer-term and to
Externí odkaz:
https://doaj.org/article/aa667d4033b34780a809474a674b58d7
Autor:
Scott T. Robinson, MD, PhD, Ruth E. Levey, BSc, Rachel Beatty, BSc, David Connolly, BSc, Eimear B. Dolan, PhD, Nicholas H. Osborne, MD, Peter Dockery, PhD, Peter K. Henke, MD, Garry P. Duffy, PhD
Publikováno v:
JVS - Vascular Science, Vol 2, Iss , Pp 13-19 (2021)
Background: Quantitative methods for evaluating microstructure of arterial specimens typically rely on histologic techniques that involve random sampling, which cannot account for the unique spatial distribution of features in three dimensions. Metho
Externí odkaz:
https://doaj.org/article/ea18bd5bd2d84a0faf11fc4a509e61cd
Autor:
Ruth E. Levey, Brooke Tornifoglio, Alan J. Stone, Christian Kerskens, Scott T. Robinson, Fergal B. Coulter, Robert Bagnall, Raymond O’Connor, Eimear B. Dolan, Peter Dockery, Gabriella Bellavia, Stefania Straino, Francesca Cianfarani, Paul Johnson, Eoin O’Cearbhaill, Caitríona Lally, Garry P. Duffy
Publikováno v:
Polymers, Vol 14, Iss 22, p 4819 (2022)
Analysing the composition and organisation of the fibrous capsule formed as a result of the Foreign Body Response (FBR) to medical devices, is imperative for medical device improvement and biocompatibility. Typically, analysis is performed using hist
Externí odkaz:
https://doaj.org/article/fed7a6d6cadc44cd8c58b23b74e12967
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 140, Iss , Pp 111702- (2021)
Cancer is one of the leading causes of deaths worldwide with 18.1 million deaths per year. Although there have been significant advances in anti-cancer therapies, they can often result in side effects with cardiovascular complications being the most
Externí odkaz:
https://doaj.org/article/fb6c82e25755410babc1a190e9d29913
Autor:
Debkalpa Goswami, Daniel A. Domingo‐Lopez, Niamh A. Ward, Jeffrey R. Millman, Garry P. Duffy, Eimear B. Dolan, Ellen T. Roche
Publikováno v:
Advanced Science, Vol 8, Iss 16, Pp n/a-n/a (2021)
Abstract Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1 Diabetes (T1D), yet successful transplantation currently necessitates long‐term modulation with immunosuppressant drugs. An alternative approach to
Externí odkaz:
https://doaj.org/article/4cf0798c8ca246f8b21fe8ecf5742881
Autor:
Karina C. Scheiner, Roel F. Maas-Bakker, Thanh T. Nguyen, Ana M. Duarte, Gert Hendriks, Lídia Sequeira, Garry P. Duffy, Rob Steendam, Wim E. Hennink, Robbert J. Kok
Publikováno v:
ACS Omega, Vol 4, Iss 7, Pp 11481-11492 (2019)
Externí odkaz:
https://doaj.org/article/51830dbdb69341d1b3d96b69de4cd68d
Autor:
Aline Zbinden, Shannon L. Layland, Max Urbanczyk, Daniel A. Carvajal Berrio, Julia Marzi, Monika Zauner, Anne Hammerschmidt, Eva M. Brauchle, Katrin Sudrow, Simon Fink, Markus Templin, Simone Liebscher, Gerd Klein, Arjun Deb, Garry P. Duffy, Gay M. Crooks, Johannes A. Eble, Hanna K. A. Mikkola, Ali Nsair, Martina Seifert, Katja Schenke‐Layland
Publikováno v:
Advanced Science, Vol 8, Iss 4, Pp n/a-n/a (2021)
Abstract Ischemia impacts multiple organ systems and is the major cause of morbidity and mortality in the developed world. Ischemia disrupts tissue homeostasis, driving cell death, and damages tissue structure integrity. Strategies to heal organs, li
Externí odkaz:
https://doaj.org/article/2b9e182dfb044863ab0a62d3b25019f2
Autor:
Ruth E. Levey, Fergal B. Coulter, Karina C. Scheiner, Stefano Deotti, Scott T. Robinson, Liam McDonough, Thanh T. Nguyen, Rob Steendam, Mark Canney, Robert Wylie, Liam P. Burke, Eimear B. Dolan, Peter Dockery, Helena M. Kelly, Giulio Ghersi, Wim E. Hennink, Robbert J. Kok, Eoin O’Cearbhaill, Garry P. Duffy
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2077 (2021)
Macroencapsulation systems have been developed to improve islet cell transplantation but can induce a foreign body response (FBR). The development of neovascularization adjacent to the device is vital for the survival of encapsulated islets and is a
Externí odkaz:
https://doaj.org/article/ae1a9923f614471a8b8059bde085de9e
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1694 (2021)
Synthetic and naturally occurring nano-sized particles present versatile vehicles for the delivery of therapy in a range of clinical settings. Their small size and modifiable physicochemical properties support refinement of targeting capabilities, im
Externí odkaz:
https://doaj.org/article/0712083151174e13ab19ca0c45c5b6e1