Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus.

Autor: Yutaka Takebe, Carrie J Saucedo, Garry Lund, Rie Uenishi, Saiki Hase, Takayo Tsuchiura, Norman Kneteman, Koreen Ramessar, D Lorne J Tyrrell, Masayuki Shirakura, Takaji Wakita, James B McMahon, Barry R O'Keefe

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64449 (2013)

Hepatitis C virus (HCV) infection is a significant public health problem with over 170,000,000 chronic carriers and infection rates increasing worldwide. Chronic HCV infection is one of the leading causes of hepatocellular carcinoma which was estimat

Externí odkaz: https://doaj.org/article/c8a6cc18c5d049bf83106bd356cfc590

Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice

Autor: Garry Lund, Catherine Fauvelle, Sneha Rangarajan, Steven K. H. Foung, Frederick W. Holtsberg, Thomas F. Baumert, Zhen Yong Keck, Norman M. Kneteman, Patrick Lau, Thomas R. Fuerst, Justin R. Bailey, Brian G. Pierce, M. Javad Aman, Kelly L. Warfield, Roy A. Mariuzza, Yong Wang, Grant C. Liao

Publikováno v: Hepatology
Hepatology, Wiley-Blackwell, 2016, 64 (6), ⟨10.1002/hep.28850⟩

Direct acting antivirals (DAAs) have led to a high cure rate in treated patients with chronic hepatitis C virus (HCV) infection but this still leaves a large number of treatment failures secondary to the emergence of resistance-associated variants (R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149f8554ed42a1c8085f03f0368bda92
https://hal.archives-ouvertes.fr/hal-02480063

Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies

Autor: Svetlana Sapelnikova, D. Lorne Tyrrell, Norman M. Kneteman, John R. Foster, Garry Lund

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 44(2)

1. Immunocompromised mice with humanized livers were developed in the mid-1990s to allow the study of human hepatotropic viruses, which normally replicate only in higher primates. The production of the uPA/SCID mouse was the vanguard of these models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24725f76f66fca9ce9cfd3d9a3569a5f
https://pubmed.ncbi.nlm.nih.gov/24320885

Lipoprotein profiles in SCID/uPA mice transplanted with human hepatocytes become human-like and correlate with HCV infection success

Autor: Rineke H G, Steenbergen, Michael A, Joyce, Garry, Lund, Jamie, Lewis, Ran, Chen, Nicola, Barsby, Donna, Douglas, Lin Fu, Zhu, D Lorne, Tyrrell, D Lorne J, Tyrrell, Norman M, Kneteman

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology. 299(4)

Although multiple determinants for hepatitis C virus (HCV) infection are known, it remains partly unclear what determines the human specificity of HCV infection. Presumably, the presence of appropriate entry receptors is essential, and this may expla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e5105a4a2c8b5c3bb1cc59fe42a1a2
https://pubmed.ncbi.nlm.nih.gov/20651006

Factors affecting hepatocyte isolation, engraftment, and replication in an in vivo model

Autor: David L.J. Tyrrell, Christian Toso, Garry Lund, Thomas A. Churchill, Jamie T. Lewis, Mahra Nourbakhsh, Donna N. Douglas, Toshiyasu Kawahara, Norman M. Kneteman

Publikováno v: Liver transplantation : official publication of the American Association for the Study of Liver Dise
Liver Transplantation, Vol. 16, No 8 (2010) pp. 974-982

Human hepatocyte transplantation is an alternative treatment for acute liver failure and liver diseases involving enzyme deficiencies. Although it has been successfully applied in selected recipients, both isolation and transplantation outcomes have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58974a4d8b0f5db9933148d477efad40
https://doi.org/10.1002/lt.22177