Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Garry L Coles"'
Autor:
Alexandros P. Drainas, Wen-Hao Hsu, Alec E. Dallas, Carson D. Poltorack, Jun W. Kim, Andy He, Garry L. Coles, Maya Baron, Michael C. Bassik, Julien Sage
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114606- (2024)
Summary: Patients with small-cell lung cancer (SCLC) are in dire need of more effective therapeutic options. Frequent disruption of the G1 checkpoint in SCLC cells creates a dependency on the G2/M checkpoint to maintain genomic integrity. Indeed, in
Externí odkaz:
https://doaj.org/article/823f2ba5877b4cc8829f9e361383096f
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005525 (2015)
The cell cycle must be tightly coordinated for proper control of embryonic development and for the long-term maintenance of organs such as the lung. There is emerging evidence that Kinesin family member 7 (Kif7) promotes Hedgehog (Hh) signaling durin
Externí odkaz:
https://doaj.org/article/185c25300e644a3fb7b2207e912eaac2
Autor:
Yan Ting Shue, Alexandros P. Drainas, Nancy Yanzhe Li, Sarah M. Pearsall, Derrick Morgan, Nasa Sinnott-Armstrong, Susan Q. Hipkins, Garry L. Coles, Jing Shan Lim, Anthony E. Oro, Kathryn L. Simpson, Caroline Dive, Julien Sage
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Notch signaling is known to control neuroendocrine fate in the lungs. Shue and colleagues further identify the REST and YAP transcriptional regulators as key components of the Notch signaling pathway in the control of the neuroendocrine cell fate in
Externí odkaz:
https://doaj.org/article/26be3ba323444a888bbc657c28aa7b6e
Autor:
Myung Chang Lee, Hongchen Cai, Christopher W. Murray, Chuan Li, Yan Ting Shue, Laura Andrejka, Andy L. He, Alessandra M.E. Holzem, Alexandros P. Drainas, Julie H. Ko, Garry L. Coles, Christina Kong, Shirley Zhu, ChunFang Zhu, Jason Wang, Matt van de Rijn, Dmitri A. Petrov, Monte M. Winslow, Julien Sage
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111990- (2023)
Summary: Small cell lung cancer (SCLC) is a lethal form of lung cancer. Here, we develop a quantitative multiplexed approach on the basis of lentiviral barcoding with somatic CRISPR-Cas9-mediated genome editing to functionally investigate candidate r
Externí odkaz:
https://doaj.org/article/0a467d5273d64bf6976383eac519d5b0
Single-cell transcriptomics reveals the effect of PD-L1/TGF-β blockade on the tumor microenvironment
Autor:
Yoong Wearn Lim, Garry L. Coles, Savreet K. Sandhu, David S. Johnson, Adam S. Adler, Erica L. Stone
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background The anti-tumor activity of anti-PD-1/PD-L1 therapies correlates with T cell infiltration in tumors. Thus, a major goal in oncology is to find strategies that enhance T cell infiltration and efficacy of anti-PD-1/PD-L1 therapy. TGF
Externí odkaz:
https://doaj.org/article/00fd9007a4614376a1b047d12d4c3430
Autor:
Julien Sage, Kévin Contrepois, Michael P. Snyder, Lauren Averett Byers, Laurent Le Cam, Andrew He, Alexandros P. Drainas, Jun W. Kim, Stuart C. Williamson, Triparna Sen, Siqi Cao, Julia Arand, Maya Gershkovitz, Daniel Hornburg, Garry L. Coles, Sandra Cristea
Related to Figure 1: MEK5 and ERK5 mRNA and protein knock-down inhibits the expansion of SCLC cells in culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8694042e6ead30505bc142fe09507ab7
https://doi.org/10.1158/0008-5472.22425223
https://doi.org/10.1158/0008-5472.22425223
Autor:
Julien Sage, Kévin Contrepois, Michael P. Snyder, Lauren Averett Byers, Laurent Le Cam, Andrew He, Alexandros P. Drainas, Jun W. Kim, Stuart C. Williamson, Triparna Sen, Siqi Cao, Julia Arand, Maya Gershkovitz, Daniel Hornburg, Garry L. Coles, Sandra Cristea
The 16 Supplementary Tables in the document provide information (including raw data) related to data throughout the manuscript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c005d71ee3bcbed4a188ddae7297e9
https://doi.org/10.1158/0008-5472.22425208.v1
https://doi.org/10.1158/0008-5472.22425208.v1
Autor:
Julien Sage, Kévin Contrepois, Michael P. Snyder, Lauren Averett Byers, Laurent Le Cam, Andrew He, Alexandros P. Drainas, Jun W. Kim, Stuart C. Williamson, Triparna Sen, Siqi Cao, Julia Arand, Maya Gershkovitz, Daniel Hornburg, Garry L. Coles, Sandra Cristea
Small-cell lung cancer (SCLC) is an aggressive form of lung cancer with dismal survival rates. While kinases often play key roles driving tumorigenesis, there are strikingly few kinases known to promote the development of SCLC. Here, we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376f1eba3da9fa6711bd4752d3a5803f
https://doi.org/10.1158/0008-5472.c.6511972.v1
https://doi.org/10.1158/0008-5472.c.6511972.v1
Autor:
Bill Chiu, Sheri L. Spunt, James C.Y. Dunn, Kathleen M. Sakamoto, Norman J. Lacayo, Florette K. Hazard, Matias Bruzoni, Enrico Danzer, Jordan S. Taylor, Garry L. Coles, Nathan Sumarsono, Jasmine Zeki, Min Huang
Neuroblastoma is a deadly pediatric solid tumor with infrequent recurrent somatic mutations. Particularly, the pathophysiology of tumors without MYCN amplification remains poorly defined. Utilizing an unbiased approach, we performed gene set enrichme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0978b1bfa756c0bbd8dcb526b67e56
https://doi.org/10.1158/0008-5472.c.6512389
https://doi.org/10.1158/0008-5472.c.6512389
Autor:
Julien Sage, Kévin Contrepois, Michael P. Snyder, Lauren Averett Byers, Laurent Le Cam, Andrew He, Alexandros P. Drainas, Jun W. Kim, Stuart C. Williamson, Triparna Sen, Siqi Cao, Julia Arand, Maya Gershkovitz, Daniel Hornburg, Garry L. Coles, Sandra Cristea
Detailed methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370afdd168318d99a3d7e69cc6eb4510
https://doi.org/10.1158/0008-5472.22425205
https://doi.org/10.1158/0008-5472.22425205