Výsledky vyhledávání - "Garry L Coles"

Akademický článek

KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.

Autor: Garry L Coles, Laurel A Baglia, Kate G Ackerman

Publikováno v: PLoS Genetics, Vol 11, Iss 10, p e1005525 (2015)

The cell cycle must be tightly coordinated for proper control of embryonic development and for the long-term maintenance of organs such as the lung. There is emerging evidence that Kinesin family member 7 (Kif7) promotes Hedgehog (Hh) signaling durin

Externí odkaz: https://doaj.org/article/185c25300e644a3fb7b2207e912eaac2

Zobrazit plný text záznamu

Akademický článek

GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer

Autor: Alexandros P. Drainas, Wen-Hao Hsu, Alec E. Dallas, Carson D. Poltorack, Jun W. Kim, Andy He, Garry L. Coles, Maya Baron, Michael C. Bassik, Julien Sage

Publikováno v: Cell Reports, Vol 43, Iss 8, Pp 114606- (2024)

Summary: Patients with small-cell lung cancer (SCLC) are in dire need of more effective therapeutic options. Frequent disruption of the G1 checkpoint in SCLC cells creates a dependency on the G2/M checkpoint to maintain genomic integrity. Indeed, in

Externí odkaz: https://doaj.org/article/823f2ba5877b4cc8829f9e361383096f

Zobrazit plný text záznamu

Akademický článek

A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs

Autor: Yan Ting Shue, Alexandros P. Drainas, Nancy Yanzhe Li, Sarah M. Pearsall, Derrick Morgan, Nasa Sinnott-Armstrong, Susan Q. Hipkins, Garry L. Coles, Jing Shan Lim, Anthony E. Oro, Kathryn L. Simpson, Caroline Dive, Julien Sage

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Notch signaling is known to control neuroendocrine fate in the lungs. Shue and colleagues further identify the REST and YAP transcriptional regulators as key components of the Notch signaling pathway in the control of the neuroendocrine cell fate in

Externí odkaz: https://doaj.org/article/26be3ba323444a888bbc657c28aa7b6e

Zobrazit plný text záznamu

Akademický článek

A multiplexed in vivo approach to identify driver genes in small cell lung cancer

Autor: Myung Chang Lee, Hongchen Cai, Christopher W. Murray, Chuan Li, Yan Ting Shue, Laura Andrejka, Andy L. He, Alessandra M.E. Holzem, Alexandros P. Drainas, Julie H. Ko, Garry L. Coles, Christina Kong, Shirley Zhu, ChunFang Zhu, Jason Wang, Matt van de Rijn, Dmitri A. Petrov, Monte M. Winslow, Julien Sage

Publikováno v: Cell Reports, Vol 42, Iss 1, Pp 111990- (2023)

Summary: Small cell lung cancer (SCLC) is a lethal form of lung cancer. Here, we develop a quantitative multiplexed approach on the basis of lentiviral barcoding with somatic CRISPR-Cas9-mediated genome editing to functionally investigate candidate r

Externí odkaz: https://doaj.org/article/0a467d5273d64bf6976383eac519d5b0

Zobrazit plný text záznamu

Akademický článek

Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer

Publikováno v: Cell Reports, Vol 16, Iss 3, Pp 644-656 (2016)

Small cell lung cancer (SCLC) is a neuroendocrine lung cancer characterized by fast growth, early dissemination, and rapid resistance to chemotherapy. We identified a population of long-term tumor-propagating cells (TPCs) in a mouse model of SCLC. Th

Externí odkaz: https://doaj.org/article/42469f1e4e5a450c8d76fbf3b09b570b

Zobrazit plný text záznamu

Data from The MEK5–ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer

Autor: Julien Sage, Kévin Contrepois, Michael P. Snyder, Lauren Averett Byers, Laurent Le Cam, Andrew He, Alexandros P. Drainas, Jun W. Kim, Stuart C. Williamson, Triparna Sen, Siqi Cao, Julia Arand, Maya Gershkovitz, Daniel Hornburg, Garry L. Coles, Sandra Cristea

Small-cell lung cancer (SCLC) is an aggressive form of lung cancer with dismal survival rates. While kinases often play key roles driving tumorigenesis, there are strikingly few kinases known to promote the development of SCLC. Here, we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376f1eba3da9fa6711bd4752d3a5803f
https://doi.org/10.1158/0008-5472.c.6511972.v1

Zobrazit plný text záznamu

Data from Epigenetic Targeting of TERT-Associated Gene Expression Signature in Human Neuroblastoma with TERT Overexpression

Autor: Bill Chiu, Sheri L. Spunt, James C.Y. Dunn, Kathleen M. Sakamoto, Norman J. Lacayo, Florette K. Hazard, Matias Bruzoni, Enrico Danzer, Jordan S. Taylor, Garry L. Coles, Nathan Sumarsono, Jasmine Zeki, Min Huang

Neuroblastoma is a deadly pediatric solid tumor with infrequent recurrent somatic mutations. Particularly, the pathophysiology of tumors without MYCN amplification remains poorly defined. Utilizing an unbiased approach, we performed gene set enrichme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0978b1bfa756c0bbd8dcb526b67e56
https://doi.org/10.1158/0008-5472.c.6512389

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání