Výsledky vyhledávání - "Garry J, Rucklidge"

Anti-platelet effects of olive oil extract: in vitro functional and proteomic studies

Autor: Niamh O'Kennedy, Baukje de Roos, Xuguang Zhang, Sharon Wood, Louise Cantlay, Guillermo Rodriguez Gutierrez, Garry J. Rucklidge, Garry G. Duthie, Martin D. Reid, Gary Duncan

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Purpose: Platelets play a key role in haemostasis and wound healing, contributing to formation of vascular plugs. They are also involved in formation of atherosclerosic plaques. Some traditional diets, like the Mediterranean diet, are associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1124ac7c12cb14ade0cb567747e93cd
https://doi.org/10.1007/s00394-010-0162-3

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Attenuation of inflammation and cellular stress-related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout mice on a high-fat diet

Autor: Garry J. Rucklidge, Sinead Toomey, Helen M. Roche, Christine E. Loscher, John A. Browne, Graham W. Horgan, Gary Duncan, Baukje de Roos, Karen Ross, Martin D. Reid, Kingston H. G. Mills, Vanessa Rungapamestry

Publikováno v: PROTEOMICS. 9:3244-3256

The development of insulin resistance in the obese is associated with chronic, low-grade inflammation. We aimed to identify novel links between obesity, insulin resistance and the inflammatory response by comparing C57BL/6 with type I interleukin-1 r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b2b5272188cf109e786883f3ef3e10
https://doi.org/10.1002/pmic.200800761

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Gene and protein expression profiles in the foetal liver of the pregnant rat fed a low protein diet

Autor: Garry J. Rucklidge, Susan M. Hay, Christopher J. McNeil, Gary Duncan, Martin D. Reid, William D. Rees

Publikováno v: Genes & Nutrition. 4:189-194

Foetal growth is particularly sensitive to the protein content of the mother's diet. Microarray data from the foetal liver of pregnant rats fed normal (HP) or reduced protein diets (LP) were compared by gene set enrichment analysis. Soluble proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf1d8b3af4122975acb5c222916df8d
https://doi.org/10.1007/s12263-009-0125-6

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Influence of increased adiposity on mitochondrial-associated proteins of the rat colon: A proteomic and transcriptomic analysis

Autor: Sara Padidar, Janice E. Drew, Garry J. Rucklidge, Andrew J. Farquharson

Publikováno v: Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2008, 1782 (9), pp.532. ⟨10.1016/j.bbadis.2008.06.002⟩

Epidemiological studies report obesity to be an important risk factor influencing colon pathologies, yet mechanism(s) are unknown. Recent studies have shown significant elevation of insulin, leptin and triglycerides associated with increased adipose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83cf9d65a03a413ce960d63e0d30d36d

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The Response of Human Colonocytes to Folate Deficiency in Vitro: Functional and Proteomic Analyses

Autor: Lynn P. Pirie, Gary Duncan, Garry J. Rucklidge, Charles S. Bestwick, Mary Pat Moyer, Martin D. Reid, Susan J. Duthie, Yiannis Mavrommatis

Publikováno v: Journal of Proteome Research. 7:3254-3266

Low folate intake is associated with colon cancer. We combined a proteomics and biochemical approach to identify proteins and pathways affected by folate deficiency in human colonocytes. Folate differentially altered activity and expression of protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86d4920bc3aaf3afc748fa87d6e92a2
https://doi.org/10.1021/pr700751y

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Disruption of lipid metabolism in the liver of the pregnant rat fed folate-deficient and methyl donor-deficient diets

Autor: Susan Hay, Garry J. Rucklidge, William D. Rees, Christopher A. Maloney, Gary Duncan, Martin D. Reid, Christopher J. McNeil

Publikováno v: British Journal of Nutrition. 99:262-271

The importance of folic acid and the methionine cycle in fetal development is well recognised even though the mechanism has not been established. Since the cycle is active in the maternal liver, poor folate status may modify hepatic metabolism. Pregn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b1509d9edec0abdd5f668f07980507
https://doi.org/10.1017/s0007114507798999

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Extra Virgin Olive Oils Increase Hepatic Fat Accumulation and Hepatic Antioxidant Protein Levels in APOE-/- Mice

Autor: John R. Arthur, Gary Duncan, Carmen Arnal, Garry J. Rucklidge, Karen Ross, Jesús Osada, Jose M. Arbones-Mainar, Graham W. Horgan, Baukje de Roos, María A. Navarro, Martin D. Reid, Ricardo Carnicer

Publikováno v: Journal of Proteome Research. 6:4041-4054

We assessed the effects of Picual and Arbequina olive oil, rich and poor in polyphenols, respectively, on plasma lipid and glucose metabolism, hepatic fat content, and the hepatic proteome in female Apoe-/- mice. Both olive oils increased hepatic fat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ce0d171d66a977c3db5fb8bee5755b
https://doi.org/10.1021/pr070321a

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Salicylate modulates oxidative stress in the rat colon: A proteomic approach

Autor: Gary Duncan, Garry J. Rucklidge, Sara Padidar, Graham W. Horgan, Garry G. Duthie, Martin D. Reid, Janice E. Drew, Wendy R. Russell

Publikováno v: Biochemical Pharmacology. 72:204-216

The dietary phenolic compound, salicylic acid, decreases oxidative stress and pro-inflammatory and potentially neo-plastic prostaglandins with a concomitant increase in glutathione peroxidase activity. Salicylic acid, a dietary plant-based phenolic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83977f9f647dc34e296f13a023322275
https://doi.org/10.1016/j.bcp.2006.04.012

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A novel class of CoA-transferase involved in short-chain fatty acid metabolism in butyrate-producing human colonic bacteria

Autor: Petra Louis, Pauline Young, Valerie J. Russell, Cedric Charrier, Donna L. Henderson, Garry J. Rucklidge, Rustam Aminov, Harry J. Flint, Gary Duncan, Martin D. Reid

Publikováno v: Microbiology. 152:179-185

Bacterial butyryl-CoA CoA-transferase activity plays a key role in butyrate formation in the human colon, but the enzyme and corresponding gene responsible for this activity have not previously been identified. A novel CoA-transferase gene is describ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a8eb7fe07ddce77dc7df0ba67edad8
https://doi.org/10.1099/mic.0.28412-0

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