Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Garry Cuneo"'
Autor:
Bagna Bao, Kevin Groves, Jun Zhang, Emma Handy, Paul Kennedy, Garry Cuneo, Claudiu T Supuran, Wael Yared, Milind Rajopadhye, Jeffrey D Peterson
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50860 (2012)
Carbonic anhydrase IX (CA IX) is a transmembrane protein that has been shown to be greatly upregulated under conditions of hypoxia in many tumor cell lines. Tumor hypoxia is associated with impaired efficacy of cancer therapies making CA IX a valuabl
Externí odkaz:
https://doaj.org/article/2af1b821387541c8856d05fe84d013ae
Autor:
Franziska G Leifer, William M. Shih, Donald E. Ingber, Ju Hee Ryu, Nandhini Ponnuswamy, Chenxiang Lin, Maartje M. C. Bastings, Frances M. Anastassacos, Garry Cuneo
Publikováno v:
Nano letters. 18(6)
Designer nanoparticles with controlled shapes and sizes are increasingly popular vehicles for therapeutic delivery due to their enhanced cell-delivery performance. However, our ability to fashion nanoparticles has offered only limited control over th
Autor:
Garry Cuneo, Amanda Jiang, Anne-Laure Papa, Tadanori Mammoto, Donald E. Ingber, Chris Johnson, Netanel Korin, Akiko Mammoto, Robert Mannix, Deen Bhatta, Mathumai Kanapathipillai, Oktay Uzun
Publikováno v:
Biomaterials. 139
Here we describe injectable, ultrasound (US)-responsive, nanoparticle aggregates (NPAs) that disintegrate into slow-release, nanoscale, drug delivery systems, which can be targeted to selective sites by applying low-energy US locally. We show that, u
Autor:
Wael Yared, Kevin Groves, Garry Cuneo, Bagna Bao, Jeffrey D. Peterson, Paul Kennedy, Claudiu T. Supuran, Emma Handy, Milind Rajopadhye, Jun Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:653-657
A series of human carbonic anhydrase (hCA) IX inhibitors conjugated to various near-infrared fluorescent dyes was synthesized with the aim of imaging hypoxia-induced hCA IX expression in tumor cells in vitro, ex vivo and in vivo. The resulting compou
Autor:
Milind Rajopadhye, Jeffrey Morin, Garry Cuneo, Jeffrey D. Peterson, Guojie Ho, Wael Yared, Jeannine Delaney, Sylvie Kossodo
Publikováno v:
Journal of biomedical optics. 18(10)
Assays for blood levels of prostate-specific antigen (PSA), performed in prostate cancer detection, measure mostly inactive/complexed PSA and do not provide information regarding enzymatically active PSA, which is biologically more relevant. Thus, we
Autor:
Wael Yared, Paul Kennedy, Claudiu T. Supuran, Milind Rajopadhye, Bagna Bao, Jun Zhang, Jeffrey D. Peterson, Garry Cuneo, Emma Handy, Kevin Groves
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 11, p e50860 (2012)
PLoS ONE, Vol 7, Iss 11, p e50860 (2012)
Carbonic anhydrase IX (CA IX) is a transmembrane protein that has been shown to be greatly upregulated under conditions of hypoxia in many tumor cell lines. Tumor hypoxia is associated with impaired efficacy of cancer therapies making CA IX a valuabl
Autor:
Sylvie Kossodo, Emma Handy, Jeff Morin, Garry Cuneo, Milind Rajopadhye, Jeannine Delaney, Jeffrey D. Peterson, Kevin Groves, Jun Zhang, Wael Yared
Publikováno v:
International Journal of Molecular Imaging
We developed a neutrophil elastase-specific near-infrared fluorescence imaging agent, which, combined with fluorescence molecular tomographic imaging, allowed us to detect and quantify neutrophil elastase activityin vivo, in real time, and noninvasiv
Autor:
Jayme Jensen, Maureen Pickarski, Guojie Ho, Cyrille Sur, Le Thi Duong, Alexa Gleason, Jun Zhang, Garry Cuneo, Bohumil Bednar, Renee C. Gaspar, Milind Rajopadhye, Shu-An Lin, Wael Yared, George D. Hartman, Chiara Buono, Agnieszka Blusztajn, Richard Hargreaves, Paul J. Coleman, Jeffrey D. Peterson, Sylvie Kossodo
Publikováno v:
Molecular imaging and biology. 12(5)
Integrins, especially α(v)β(3) and α(v)β(5), are upregulated in tumor cells and activated endothelial cells and as such, serve as cancer biomarkers. We developed a novel near-infrared-labeled optical agent for the in vivo detection and quantifica
Autor:
Jun Zhang, Wael Yared, Garry Cuneo, Bagna Bao, Jeffrey D. Peterson, Kevin Groves, Milind Rajopadhye
Publikováno v:
Cancer Research. 72:2444-2444
Folate receptors (FR) are overexpressed on the surface of many different human tumor cells, including ovarian, breast, cervical, renal, colorectal and nasopharyngeal cancer cells, with little expression in normal tissues. As such, folic acid has been
Autor:
Jun Zhang, Paul Kennedy, Claudiu T. Supuran, Bagna Bao, Garry Cuneo, Emma Handy, Milind Rajopadhye, Jeffrey D. Peterson, Wael Yared, Kevin Groves
Publikováno v:
Cancer Research. 72:3949-3949
Carbonic anhydrase IX (CA IX), a cell surface enzyme involved in tumor cell acidification, is induced during tumor hypoxia (lack of oxygen) in many different types of tumors. CA IX expression is correlated to tumor cell proliferation and metastasis,