Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Garry A. Neil"'
Autor:
David S. Perlin, Garry A. Neil, Colleen Anderson, Inbal Zafir-Lavie, Shane Raines, Carl F. Ware, H. Jeffrey Wilkins
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
BACKGROUND Severe coronavirus disease 2019 (COVID-19) is associated with a dysregulated immune response, which can result in cytokine-release syndrome and acute respiratory distress syndrome (ARDS). Patients with COVID-19–associated ARDS have eleva
Externí odkaz:
https://doaj.org/article/f2e589d1155e44c1a9730085087bef7e
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
ABSTRACT Many coronavirus disease 2019 (COVID-19) patients demonstrate lethal respiratory complications caused by cytokine release syndrome (CRS). Multiple cytokines have been implicated in CRS, but levels of tumor necrosis factor superfamily 14 (TNF
Externí odkaz:
https://doaj.org/article/b31d84eeb6554586a6b238fe7feda2af
Publikováno v:
Journal of Experimental Medicine. 219
Advances in understanding the physiologic functions of the tumor necrosis factor superfamily (TNFSF) of ligands, receptors, and signaling networks are providing deeper insight into pathogenesis of infectious and autoimmune diseases and cancer. LIGHT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e5c42397baba22e9dedea856824346
https://doi.org/10.1084/jem.20220236
https://doi.org/10.1084/jem.20220236
Autor:
Inbal Zafir-Lavie, Reem Miari, Osnat Tal, Atar Liran, Ronit Satchi-Fainaro, Garry A. Neil, Haim Goltsman, Tamar Shatil, Amos Panet, Shay Sherbo, Felix Badinter, Simi Krispel, Paula Ofek, Itai Benhar, Eilam Yeini, Nir Shapir
Publikováno v:
Journal of Controlled Release. 291:80-89
Background Trastuzumab is a monoclonal antibody which demonstrates efficacy for HER2 positive breast cancer patients. Recently, an increased incidence of brain metastasis in trastuzumab-treated patients has been reported. The reason for this may be t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9135a5400ec75b15396bfec990af7e
https://doi.org/10.1016/j.jconrel.2018.10.017
https://doi.org/10.1016/j.jconrel.2018.10.017
Autor:
Garry A. Neil, Lori Roadcap, Wilkins Hj, Shane Raines, Carl F. Ware, Inbal Zafir-Lavie, David S. Perlin, Anderson C
BackgroundSevere COVID-19 infection is associated with dysregulated immune response which, in a substantial minority of patients, results in cytokine release syndrome (CRS) and acute respiratory distress syndrome (ARDS). Inhibition of cytokines or cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4688844433fa9d485fac9c357ef0d52d
https://doi.org/10.1101/2021.04.03.21254748
https://doi.org/10.1101/2021.04.03.21254748
Publikováno v:
Immune Modulating Agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95323220c4ee11d5143c20fcc5411bc0
https://doi.org/10.1201/9781003064671-13
https://doi.org/10.1201/9781003064671-13
Publikováno v:
mSphere
mSphere, Vol 5, Iss 4 (2020)
mSphere, Vol 5, Iss 4, p e00699-20 (2020)
mSphere, Vol 5, Iss 4 (2020)
mSphere, Vol 5, Iss 4, p e00699-20 (2020)
Many coronavirus disease 2019 (COVID-19) patients demonstrate lethal respiratory complications caused by cytokine release syndrome (CRS). Multiple cytokines have been implicated in CRS, but levels of tumor necrosis factor superfamily 14 (TNFSF14) (LI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6083cd27bebfe5a4ab040764bd645dd
https://doi.org/10.1101/2020.07.27.20152892
https://doi.org/10.1101/2020.07.27.20152892
Autor:
Hagit Domev, Despina Sitara, Nir Shapir, Garry A. Neil, Mariateresa Pettinato, Giuliana Ferrari, Emir O'Hara, Kevin A. Munoz, Antonella Nai, Maria Rosa Lidonnici, Shuling Guo, Stefano Rivella, Vania Lo Presti, Carla Casu, Simona Maria Di Modica, Violante Olivari, Sheri L. Booten, Alison Liu, Reem Miari, Mariam Aghajan, Inbal Zafir-Lavie
Publikováno v:
Blood
β-Thalassemia intermedia is a disorder characterized by ineffective erythropoiesis (IE), anemia, splenomegaly, and systemic iron overload. Novel approaches are being explored based on the modulation of pathways that reduce iron absorption (ie, using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f29510b23b4111ef44430637443e8f
Autor:
Emad N. Eskandar, Joshua P. Aronson, Garry A. Neil, Nir Shapir, Craig M. Neville, Olive Mwizerwa, Irina Pomerantseva, Husam A. Katnani, Cathryn A. Sundback, Haim Goltsman, Reem Miari, H. Tse
Publikováno v:
International Journal of Pharmaceutics. 534:42-49
Systemic delivery of therapeutic proteins to the central nervous system (CNS) is challenging because of the blood-brain barrier restrictions. Direct intrathecal delivery is possible but does not produce stable concentrations. We are proposing an alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e44c829a38ee4c2e201b0c307113ca
https://doi.org/10.1016/j.ijpharm.2017.10.002
https://doi.org/10.1016/j.ijpharm.2017.10.002
Autor:
Reem Miari, Garry A. Neil, Daniel Afik, Nir Shapir, Amos Panet, Shany Blum, Gil Chernin, Doron Schwartz
Publikováno v:
Human Gene Therapy Clinical Development. 26:216-227
Protein drugs are currently delivered by bolus injection and although treatment frequently is successful, these methods also have major drawbacks, which call for the development of alternative technologies allowing prolonged delivery of these drugs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f7ccd2512263b17eaa97331d12bc8d
https://doi.org/10.1089/humc.2015.125
https://doi.org/10.1089/humc.2015.125