Driving down malaria transmission with engineered gene drives

Autor: Garrood, WT, Cuber, P, Willis, K, Bernardini, F, Page, NM, Haghighat-Khah, RE

Publikováno v: Frontiers in genetics

The last century has witnessed the introduction, establishment and expansion of mosquito-borne diseases into diverse new geographic ranges. Malaria is transmitted by female Anopheles mosquitoes. Despite making great strides over the past few decades

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274b03442282a3b2e590fafae85e158c
https://pubmed.ncbi.nlm.nih.gov/36338968

P450 gene duplication and divergence led to the evolution of dual novel functions and insecticide cross-resistance in the brown planthopper Nilaparvata lugens.

Autor: Duarte A; College for Life and Environmental Sciences, University of Exeter, Penryn, Cornwall, United Kingdom., Pym A; College for Life and Environmental Sciences, University of Exeter, Penryn, Cornwall, United Kingdom., Garrood WT; Department of Life Sciences, Imperial College London, South Kensington Campus, London, United Kingdom., Troczka BJ; College for Life and Environmental Sciences, University of Exeter, Penryn, Cornwall, United Kingdom., Zimmer CT; College for Life and Environmental Sciences, University of Exeter, Penryn, Cornwall, United Kingdom.; Syngenta Crop Protection, Werk Stein, Schaffhauserstrasse, Stein, Switzerland., Davies TGE; Department of Biointeractions and Crop Protection, Rothamsted Research, Harpenden, United Kingdom., Nauen R; Bayer AG, Crop Science Division, Alfred Nobel-Strasse 50, Monheim, Germany., O'Reilly AO; School of Biological & Environmental Sciences, Liverpool John Moores University, Liverpool, United Kingdom., Bass C; College for Life and Environmental Sciences, University of Exeter, Penryn, Cornwall, United Kingdom.

Publikováno v: PLoS genetics [PLoS Genet] 2022 Jun 21; Vol. 18 (6), pp. e1010279. Date of Electronic Publication: 2022 Jun 21 (Print Publication: 2022).

Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito.

Autor: Garrood WT; Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom., Kranjc N; Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom., Petri K; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129., Kim DY; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129., Guo JA; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129., Hammond AM; Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins University, Baltimore, MD 21205., Morianou I; Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom., Pattanayak V; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129., Joung JK; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129., Crisanti A; Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom; a.drcrisanti@imperial.ac.uk a.simoni@pologgb.com.; Department of Molecular Medicine, University of Padova, 35121 Padova, Italy., Simoni A; Department of Life Sciences, Imperial College London, SW7 2AZ London, United Kingdom; a.drcrisanti@imperial.ac.uk a.simoni@pologgb.com.; Polo d'Innovazione Genomica, Genetica, e Biologia, 05100 Terni, Italy.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jun 01; Vol. 118 (22). Date of Electronic Publication: 2021 Apr 30.

Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the Brown Planthopper.

Autor: Zimmer CT; College of Life and Environmental Sciences, Biosciences, University of Exeter, Penryn Campus, Penryn, Cornwall TR10 9FE, UK., Garrood WT; Department of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK., Singh KS; College of Life and Environmental Sciences, Biosciences, University of Exeter, Penryn Campus, Penryn, Cornwall TR10 9FE, UK., Randall E; College of Life and Environmental Sciences, Biosciences, University of Exeter, Penryn Campus, Penryn, Cornwall TR10 9FE, UK., Lueke B; Bayer AG, Crop Science Division, Alfred Nobel-Strasse 50, 40789 Monheim, Germany., Gutbrod O; Bayer AG, Crop Science Division, Alfred Nobel-Strasse 50, 40789 Monheim, Germany., Matthiesen S; Bayer AG, Crop Science Division, Alfred Nobel-Strasse 50, 40789 Monheim, Germany., Kohler M; Bayer AG, Crop Science Division, Alfred Nobel-Strasse 50, 40789 Monheim, Germany., Nauen R; Bayer AG, Crop Science Division, Alfred Nobel-Strasse 50, 40789 Monheim, Germany., Davies TGE; Department of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK., Bass C; College of Life and Environmental Sciences, Biosciences, University of Exeter, Penryn Campus, Penryn, Cornwall TR10 9FE, UK. Electronic address: c.bass@exeter.ac.uk.

Publikováno v: Current biology : CB [Curr Biol] 2018 Jan 22; Vol. 28 (2), pp. 268-274.e5. Date of Electronic Publication: 2018 Jan 11.

A CRISPR/Cas9 mediated point mutation in the alpha 6 subunit of the nicotinic acetylcholine receptor confers resistance to spinosad in Drosophila melanogaster.

Autor: Zimmer CT; Rothamsted Research, Biological Chemistry and Crop Protection Department, Harpenden, UK; College of Life and Environmental Sciences, Biosciences, University of Exeter, Penryn Campus, Penryn, Cornwall TR10 9FE, UK. Electronic address: c.t.zimmer@exeter.ac.uk., Garrood WT; Rothamsted Research, Biological Chemistry and Crop Protection Department, Harpenden, UK., Puinean AM; Rothamsted Research, Biological Chemistry and Crop Protection Department, Harpenden, UK., Eckel-Zimmer M; Rothamsted Research, Biological Chemistry and Crop Protection Department, Harpenden, UK; College of Life and Environmental Sciences, Biosciences, University of Exeter, Penryn Campus, Penryn, Cornwall TR10 9FE, UK., Williamson MS; Rothamsted Research, Biological Chemistry and Crop Protection Department, Harpenden, UK., Davies TG; Rothamsted Research, Biological Chemistry and Crop Protection Department, Harpenden, UK., Bass C; Rothamsted Research, Biological Chemistry and Crop Protection Department, Harpenden, UK; College of Life and Environmental Sciences, Biosciences, University of Exeter, Penryn Campus, Penryn, Cornwall TR10 9FE, UK.

Publikováno v: Insect biochemistry and molecular biology [Insect Biochem Mol Biol] 2016 Jun; Vol. 73, pp. 62-9. Date of Electronic Publication: 2016 Apr 24.