Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Garron T. Dodd"'
Autor:
Linda T. Nguyen, Garron T. Dodd
Publikováno v:
npj Metabolic Health and Disease, Vol 2, Iss 1, Pp 1-14 (2024)
Abstract Metabolic diseases such as obesity and type 2 diabetes affect >2 billion people worldwide, yet there are currently no effective treatments to promote remission of disease. It is therefore critical to understand the physiological and pathophy
Externí odkaz:
https://doaj.org/article/38fd9b53447446fcaa8f07c83ad2ae7a
Autor:
Vanessa R. Haynes, Natalie J. Michael, Marco van den Top, Fei-Yue Zhao, Russell D. Brown, David De Souza, Garron T. Dodd, David Spanswick, Matthew J. Watt
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 54-71 (2020)
Objectives: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and
Externí odkaz:
https://doaj.org/article/090fce1d57f8401b9e992de5fd12af30
Autor:
Amy A Worth, Rosemary Shoop, Katie Tye, Claire H Feetham, Giuseppe D'Agostino, Garron T Dodd, Frank Reimann, Fiona M Gribble, Emily C Beebe, James D Dunbar, Jesline T Alexander-Chacko, Dana K Sindelar, Tamer Coskun, Paul J Emmerson, Simon M Luckman
Publikováno v:
eLife, Vol 9 (2020)
The cytokine, GDF15, is produced in pathological states which cause cellular stress, including cancer. When over expressed, it causes dramatic weight reduction, suggesting a role in disease-related anorexia. Here, we demonstrate that the GDF15 recept
Externí odkaz:
https://doaj.org/article/825a4f2bc81540a88d659e35ab6f5327
Autor:
Garron T. Dodd, Chrysovalantou E. Xirouchaki, Matthew Eramo, Christina A. Mitchell, Zane B. Andrews, Belinda A. Henry, Michael A. Cowley, Tony Tiganis
Publikováno v:
Cell Reports, Vol 28, Iss 11, Pp 2905-2922.e5 (2019)
Summary: The importance of hypothalamic leptin and insulin resistance in the development and maintenance of obesity remains unclear. The tyrosine phosphatases protein tyrosine phosphatase 1B (PTP1B) and T cell protein tyrosine phosphatase (TCPTP) att
Externí odkaz:
https://doaj.org/article/60e76c7095e44457a9a4422b890fabd6
Autor:
Eglantine Balland, Weiyi Chen, Garron T. Dodd, Gregory Conductier, Roberto Coppari, Tony Tiganis, Michael A. Cowley
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 346-355.e3 (2019)
Summary: Insulin action in the hypothalamus results in the suppression of hepatic glucose production (HGP). Obesity is often associated with a diminished response to insulin, leading to impaired suppression of HGP in obese mice. Here, we demonstrate
Externí odkaz:
https://doaj.org/article/4127cc54a7be4866b89beba18cafd830
Autor:
Garron T Dodd, Natalie J Michael, Robert S Lee-Young, Salvatore P Mangiafico, Jack T Pryor, Astrid C Munder, Stephanie E Simonds, Jens Claus Brüning, Zhong-Yin Zhang, Michael A Cowley, Sofianos Andrikopoulos, Tamas L Horvath, David Spanswick, Tony Tiganis
Publikováno v:
eLife, Vol 7 (2018)
Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhib
Externí odkaz:
https://doaj.org/article/fab6ed8d6e114ea6b2ada91531963160
Autor:
Garron T. Dodd, David P De Souza, Russell D Brown, David Spanswick, Vanessa R. Haynes, Marco van den Top, Natalie J. Michael, Fei-Yue Zhao, Matthew J. Watt
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 34, Iss, Pp 54-71 (2020)
Molecular Metabolism, Vol 34, Iss, Pp 54-71 (2020)
Objectives Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3ae996a2befbf98fb187500b5a9cbd
https://doi.org/10.1016/j.molmet.2020.01.002
https://doi.org/10.1016/j.molmet.2020.01.002
Autor:
Ronnie Blazev, Christian S. Carl, Yaan-Kit Ng, Jeffrey Molendijk, Christian T. Voldstedlund, Yuanyuan Zhao, Di Xiao, Andrew J. Kueh, Paula M. Miotto, Vanessa R. Haynes, Justin P. Hardee, Jin D. Chung, James W. McNamara, Hongwei Qian, Paul Gregorevic, Jonathan S. Oakhill, Marco J. Herold, Thomas E. Jensen, Leszek Lisowski, Gordon S. Lynch, Garron T. Dodd, Matthew J. Watt, Pengyi Yang, Bente Kiens, Erik A. Richter, Benjamin L. Parker
Publikováno v:
Cell Metabolism. 34:1561-1577.e9
Exercise induces signaling networks to improve muscle function and confer health benefits. To identify divergent and common signaling networks during and after different exercise modalities, we performed a phosphoproteomic analysis of human skeletal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea6f7f41fb55c576c3666dbb1230ccc
https://doi.org/10.1016/j.cmet.2022.07.003
https://doi.org/10.1016/j.cmet.2022.07.003
Autor:
Dorit Samocha-Bonet, Mark Ziemann, Matthew J. Watt, René Koopman, Adam Hagg, Jerry R. Greenfield, Magdalene K. Montgomery, Hongwei Qian, Garron T. Dodd, Simon T. Bond, Darren C. Henstridge, Rachel E. Thomson, Paul Gregorevic, Talhah M. Salmi, Assam El-Osta, K. F. Harvey, Mark A. Febbraio, Choon Boon Sim, Kevin I. Watt, Brian G. Drew, Andrew G. Cox, Jonathan R. Davey, Rachel S. Lee, Benjamin L. Parker, Enzo R. Porrello
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strategies to promote skeletal muscle metabolism can be effective to limit the progression of metabolic disease. Here, we dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2fc401ce1ea70c3f249978ef0882f2b
https://doi.org/10.1038/s41467-021-23240-7
https://doi.org/10.1038/s41467-021-23240-7
Autor:
Garron T. Dodd, Zane B. Andrews, Tony Tiganis, Mathieu Méquinion, Seung Jae Kim, Chrysovalantou E. Xirouchaki, Jens C. Brüning
Publikováno v:
Science Advances
Insulin signaling in the hypothalamus limits the size of meals to prevent postprandial hyperglycemia and insulin resistance.
The importance of hypothalamic insulin signaling on feeding and glucose metabolism remains unclear. We report that insul
The importance of hypothalamic insulin signaling on feeding and glucose metabolism remains unclear. We report that insul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141f7770046d41ec14e71f00f425c88b
http://europepmc.org/articles/PMC7909880
http://europepmc.org/articles/PMC7909880