Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Garrido Montalban A"'
Autor:
Garrido Montalban, Antonio, Herrera, Antonio J., Johannsen, Jes, White, Andrew J.P., Williams, David J.
Publikováno v:
In Tetrahedron 7 October 2014 70(40):7358-7362
Autor:
You-An Ma, Robert Burda, Tawfik Gharbaoui, Graeme Semple, Robert M. Jones, Krishnan Ashwin M, Antonio Garrido Montalban, Dipanjan Sengupta, Daniel J. Buzard
Publikováno v:
Organic Process Research & Development. 19:618-623
Synthetic studies of the APD334 precursor 4-chloromethyl-1-cyclopentyl-2-(trifluoromethyl)benzene (6) are described. A two-step scalable process was developed starting from commercially available a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95bcc7292c9bbd4ea73cd8e2579bc04c
https://doi.org/10.1021/acs.oprd.5b00038
https://doi.org/10.1021/acs.oprd.5b00038
Autor:
You-An Ma, Sagun K. Tandel, Antonio Garrido Montalban, Michael J. Martinelli, Steve Johannsen
Publikováno v:
Tetrahedron Letters. 56:378-381
A novel Fischer pseudo-benzylic decarboxylation approach to the 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl system was developed starting from geminally substituted cyclopentanone derivatives and appropriately substituted phenyl hydrazines. In addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cadb89a89a3ccc9665c48bf5fc23cd50
https://doi.org/10.1016/j.tetlet.2014.11.101
https://doi.org/10.1016/j.tetlet.2014.11.101
Autor:
Antonio Garrido Montalban, Steve Chang, Shakya Sagar, P. Douglas Boatman, Weichao Chen, Dominic P. Behan, Thuy-Anh Tran, Yunqing Shi, Young-Jun Shin, Krishnan Ashwin M, Pureza Vallar, John W. Adams, David J. Unett, Michael Morgan, Bryan A. Kramer, Biman B. Pal, Hsin-Hui Shu, Anthony C. Blackburn, Juan Ramirez, Shiu-Feng Tung, Xiaohua Chen, Tina Leakakos, Ning Zou, Abu J.M. Sadeque, Tawfik Gharbaoui, Carleton R. Sage, Anna Shifrina, Graeme Semple, Ibragim Gaidarov
Publikováno v:
Journal of medicinal chemistry. 60(3)
The design and synthesis of a new series of potent non-prostanoid IP receptor agonists that showed oral efficacy in the rat monocrotaline model of pulmonary arterial hypertension (PAH) are described. Detailed profiling of a number of analogues result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3808129dea9a6540d0ac87cf636e0752
https://pubmed.ncbi.nlm.nih.gov/28072531
https://pubmed.ncbi.nlm.nih.gov/28072531
Autor:
Weichao Chen, Andrew M. Kawasaki, Dominic P. Behan, Jeff Edwards, You-An Ma, Tawfik Gharbaoui, Sun Hee Kim, Jayant Thatte, Hussien A. Al-Shamma, Carleton R. Sage, Jeremy Barden, Anthony C. Blackburn, Michelle Solomon, Xiuwen Zhu, Christopher Ronald J, David Mills, Ibragim Gaidarov, Antonio Garrido Montalban, Sangdon Han, Luis Lopez, Dipanjan Sengupta, Michael Morgan, Juerg Lehmann, Daniel J. Buzard, Graeme Semple, Kevin Whelan, Yinghong Gao, Joel Gatlin, Moody Jeanne, David J. Unett, Imelda Calderon, Lars Thoresen, Robert M. Jones, Brett Ullman, Todd Anthony, Chuan Chen, Minh Le, Khawja A. Usmani, Scott Stirn, Jaimie Karyn Rueter, Lixia Fu, Lorene Calvano, Abu J.M. Sadeque
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1313-1317
APD334 was discovered as part of our internal effort to identify potent, centrally available, functional antagonists of the S1P1 receptor for use as next generation therapeutics for treating multiple sclerosis (MS) and other autoimmune diseases. APD3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5c928b700e5c29f65a914afc10b3e5
https://doi.org/10.1021/ml500389m
https://doi.org/10.1021/ml500389m
Autor:
David J. Williams, Andrew J. P. White, Jes Johannsen, Antonio Garrido Montalban, Antonio J. Herrera
Publikováno v:
Tetrahedron. 70:7358-7362
Mono- and tri-topic ligands, based on dipyrromethenes and the 1,10-phenanthroline nucleus, as well as BF2 complexes derived thereof are described. While BODIPY 12 has been X-ray crystallographically characterized, the structural features of the free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6ed597b4842f0a897da54b8809cf7a9
https://doi.org/10.1016/j.tet.2014.07.054
https://doi.org/10.1016/j.tet.2014.07.054
Autor:
Garrido Montalban, Antonio, Ma, You-An, Johannsen, Steve, Tandel, Sagun, Martinelli, Michael J.
Publikováno v:
In Tetrahedron Letters 8 January 2015 56(2):378-381
Autor:
Antonio Garrido Montalban
Publikováno v:
Heterocycles in Natural Product Synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45a5456cce721ade077436dfe3ee72e3
https://doi.org/10.1002/9783527634880.ch9
https://doi.org/10.1002/9783527634880.ch9
Autor:
Zhijun Wang, Erik Boman, Jan Urban, Jeff Kucharski, Hiroshi Nakanishi, Jan Lundström, Nancy G. J. Delaet, Justin T. Ernst, Eddine Saiah, Christopher Lum, Eric Erb, Antonio Garrido Montalban, Susana Conde Ceide, Russell Dahl, Linda Kessler, Stephen E. Miller, Christopher J. Larson, Chau-Dung Chang, Edward Roberts, Jeffrey Kahl, Robert K. P. Sullivan, Andrew Gibbs, David Dalesandro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4819-4824
We have optimized a novel series of potent p38 MAP kinase inhibitors based on an alpha-ketoamide scaffold through structure based design that due to their extended molecular architecture bind, in addition to the ATP site, to an allosteric pocket. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646db32d2692e24d80d296daacfeccd7
https://doi.org/10.1016/j.bmcl.2010.06.102
https://doi.org/10.1016/j.bmcl.2010.06.102
Autor:
Jan Lundström, Eric Erb, Susana Conde Ceide, Eddine Saiah, Jeff Kahl, Stephen E. Miller, Andrew Gibbs, Edward Roberts, Nancy G. J. Delaet, Antonio Garrido Montalban, Robert K. P. Sullivan, Erik Boman, Zhijun Wang, Christopher J. Larson, David Dalesandro, Russell Dahl, Chau-Dung Chang, Hiroshi Nakanishi, Linda Kessler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5456-5459
We have identified a second series of potent p38 inhibitors. As with our first generation series, these compounds are based on an alpha-ketoamide scaffold. The reversal of the ketoamide order, however, introduces more chemical flexibility and in addi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8879f4a8eb58917957fc3b2d5d8d5e
https://doi.org/10.1016/j.bmcl.2008.09.028
https://doi.org/10.1016/j.bmcl.2008.09.028