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pro vyhledávání: '"Garrick H. Gu"'
Autor:
Kostadin Petrov, Bradley M. Wierbowski, Laura Aravena, Adrian Salic, Garrick H. Gu, Yangqing Xu
Publikováno v:
Dev Cell
Hedgehog signaling governs critical processes in embryogenesis, adult stem cell maintenance, and tumorigenesis. The activating ligand, Sonic hedgehog (SHH), is highly hydrophobic because of dual palmitate and cholesterol modification, and thus, its r
Autor:
Lindsey J. Moran, Jimmy A. Blair, Garrick H. Gu, Thomas E. Frederick, Bryn Falahee, Rebecca A. Dryer, Tony P. Huang, Hanna L. Shebert, Chau D. Vo, James F. Heinl, John W. Hammond, Shannon Zikovich, Peter D. Young, Taylor N. Jackvony, Douglas R. Wassarman, Juno Cho
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5235-5244
To address the growing need for new antimicrobial agents, we explored whether inhibition of bacterial signaling machinery could inhibit bacterial growth. Because bacteria rely on two-component signaling systems to respond to environmental changes, an