Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Garrett C. Heffner"'
Autor:
E Camilla Forsberg, Susan S Prohaska, Sol Katzman, Garrett C Heffner, Josh M Stuart, Irving L Weissman
Publikováno v:
PLoS Genetics, Vol 1, Iss 3, p e28 (2005)
The hematopoietic system is an invaluable model both for understanding basic developmental biology and for developing clinically relevant cell therapies. Using highly purified cells and rigorous microarray analysis we have compared the expression pat
Externí odkaz:
https://doaj.org/article/bc4ad70ba49341c7af1f1034ca399145
Autor:
Holly Horton, Lauryn Christiansen, Amanda Hamel, Olivia Garijo, Bruce E. Torbett, Philip D. Gregory, Garrett C. Heffner, Gretchen Lewis, Yegor Smurnyy, Dakota Campbell, Melissa Bonner, Wenliang Zhang, Gabor Istvan Veres, Seema Shaw, Francis J. Pierciey, Kendrick A. Goss, Mitchell Finer
Publikováno v:
Molecular Therapy
Gene therapy currently in development for hemoglobinopathies utilizes ex vivo lentiviral transduction of CD34+ hematopoietic stem and progenitor cells (HSPCs). A small-molecule screen identified prostaglandin E2 (PGE2) as a positive mediator of lenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b0e354eb4ffad2bdd82662970f9a9c
http://europepmc.org/articles/PMC5763075
http://europepmc.org/articles/PMC5763075
Autor:
Garrett C. Heffner, Richard W. Deibler, Patrick Cahan, Rui Zhao, Juli Unternaehrer, Marc W. Kirschner, Andrea Ballabeni, George Q. Daley, Paul H. Lerou
Publikováno v:
Proceedings of the National Academy of Sciences. 111:15768-15773
Rapid progression through the cell cycle and a very short G1 phase are defining characteristics of embryonic stem cells. This distinct cell cycle is driven by a positive feedback loop involving Rb inactivation and reduced oscillations of cyclins and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035d0f2bcae21533358073ade5aa9d57
https://doi.org/10.1073/pnas.1417518111
https://doi.org/10.1073/pnas.1417518111
Autor:
Dipak Panigrahy, Owen J. Tamplin, Pulin Li, Elizabeth B. Riley, Jamie L. Lahvic, Francesca G. Barrett, Teresa V. Bowman, Leonard I. Zon, Darryl C. Zeldin, Thorsten M. Schlaeger, Vera Binder, George Q. Daley, Garrett C. Heffner, Emily K. Pugach, Shannon McKinney-Freeman
Publikováno v:
Nature. 573:E1-E1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d46f2dd0eb1555672cb4b281fb4c19d4
https://doi.org/10.1038/s41586-019-1489-4
https://doi.org/10.1038/s41586-019-1489-4
Autor:
Shannon McKinney-Freeman, Michael Welsh, Jan Grawé, Garrett C Heffner, George Q. Daley, Matthew Curran, Karin Gustafsson, Pamela L. Wenzel
Publikováno v:
Experimental Cell Research. 319:1852-1864
The widely expressed adaptor protein Shb has previously been reported to contribute to T cell function due to its association with the T cell receptor and furthermore, several of Shb's known interaction partners are established regulators of blood ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72db20b8968ea1b974fb87ed798b561e
https://doi.org/10.1016/j.yexcr.2013.03.020
https://doi.org/10.1016/j.yexcr.2013.03.020
Publikováno v:
Stem Cells. 29:1774-1782
Hematopoietic stem cells (HSCs) must exhibit tight regulation of both self-renewal and differentiation to maintain homeostasis of the hematopoietic system as well as to avoid aberrations in growth that may result in leukemias or other disorders. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b644405822d218013b33463b2ca962
https://doi.org/10.1002/stem.719
https://doi.org/10.1002/stem.719
Autor:
In-Hyun Park, Yuin-Han Loh, Chunguang Guo, Suneet Agarwal, Francois Vigneault, James J. Collins, George Q. Daley, Stefan Irion, George M. Church, Hu Li, Garrett C. Heffner, Odelya Hartung, Philip D. Manos, Achia Urbach, Marica Grskovic, M. William Lensch, Julie M. Sahalie
Publikováno v:
Cell Stem Cell. 7(1):15-19
A manuscript has appeared online demonstrating isolation of iPSCs from peripheral blood, including a single line that showed evidence for both TCR-β and TCR-γ rearrangement by PCR (Kunisato, A., Wakatsuki, M., Shinba, H., Ota, T., Ishida, I., and N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b3e10ab7f82cfbebf9d6b3b6666b63
Autor:
Kitwa Ng, Justine D. Miller, Kitai Kim, Achia Urbach, Hongguang Huo, In-Hyun Park, Yuin-Han Loh, Garrett C. Heffner, George Q. Daley, Suneet Agarwal
Publikováno v:
Blood. 113:5476-5479
Human dermal fibroblasts obtained by skin biopsy can be reprogrammed directly to pluripotency by the ectopic expression of defined transcription factors. Here, we describe the derivation of induced pluripotent stem cells from CD34+ mobilized human pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8042b816319af3d10ef5e9df808bd11c
https://doi.org/10.1182/blood-2009-02-204800
https://doi.org/10.1182/blood-2009-02-204800
Autor:
Yegor Smurnyy, Kendrick A. Goss, Philip A. Gregory, Dakota Campbell, Byoung Y. Ryu, Olivier Negre, Seema Shah, Gretchen Lewis, Holly M. Horton, F. John Pierciey, Lauryn Christiansen, Amanda Hamel, Mitchell Finer, Christopher J. Horvath, Melissa Bonner, Wen Zhang, Gabor Istvan Veres, Garrett C. Heffner
Publikováno v:
Molecular Therapy. 24:S89-S90
Gene therapy for congenital hematopoietic disorders frequently relies on ex vivo lentiviral transduction of isolated CD34+ hematopoietic progenitor cells. Through a high-throughput small molecule screen, we identified PGE2 as a positive mediator of l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::056edb3e27e49acd3e27becb5a473497
https://doi.org/10.1016/s1525-0016(16)33038-6
https://doi.org/10.1016/s1525-0016(16)33038-6
Autor:
Leonard I. Zon, Darryl C. Zeldin, Shannon McKinney-Freeman, George Q. Daley, Pulin Li, Thorsten M. Schlaeger, Vera Binder, Garrett C. Heffner, Elizabeth B. Riley, Dipak Panigrahy, Teresa V. Bowman, Jamie L. Lahvic, Emily K. Pugach, Owen J. Tamplin, Francesca G. Barrett
Publikováno v:
Nature
Haematopoietic stem and progenitor cell (HSPC) transplant is a widely used treatment for life-threatening conditions such as leukaemia; however, the molecular mechanisms regulating HSPC engraftment of the recipient niche remain incompletely understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a050c5eba54a1bf1f91a148814f743ce
https://pubmed.ncbi.nlm.nih.gov/31435017
https://pubmed.ncbi.nlm.nih.gov/31435017