Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Garrett Berlond Minne"'
Autor:
Garrett Berlond Minne, Michel Surkyn, Harrie J.M. Gijsen, Francois Paul Bischoff, Nigel Austin, Marc Mercken, Didier Berthelot, Chiara Zavattaro, Ishtiyaque Ahmad, Gregor James Macdonald, Adriana Ingrid Velter, Michel Anna Jozef De Cleyn, Deborah Dhuyvetter, Sven Franciscus Anna Van Brandt, Serge Maria Aloysius Pieters, Yves Emiel Maria Van Roosbroeck, Swapan Kumar Samanta, Herman Borghys
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(14)
The discovery, design and synthesis of a new series of GSMs is described. The classical imidazole heterocycle has been replaced by a cyano group attached to an indole nucleus. The exploration of this series has led to compound 26-S which combined hig
Autor:
Harrie J.M. Gijsen, Francois Paul Bischoff, Serge Maria Aloysius Pieters, Yves Emiel Maria Van Roosbroeck, Didier Berthelot, Chantal Masungi, Andrés A. Trabanco, Garrett Berlond Minne, Gary Tresadern, Adriana Ingrid Velter, Frederik J. R. Rombouts, Michel Anna Jozef De Cleyn, Libuse Jaroskova, Michel Surkyn, Tongfei Wu, Sven Franciscus Anna Van Brandt, Daniel Oehlrich, Gregor James Macdonald, Herman Borghys, Marc Mercken
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(24)
The design and synthesis of a novel series of potent gamma secretase modulators is described. Exploration of various spacer groups between the triazole ring and the aromatic appendix in 2 has led to anilinotriazole 28, which combined high in vitro an
Autor:
Garrett Berlond Minne, Michel Surkyn, Marc Mercken, D. Oehlrich, Serge Pieters, Gary Tresadern, Chantal Masungi, François P. Bischoff, Andrés A. Trabanco, Ingrid Velter, Mirko Zaja, Harrie J.M. Gijsen, Gregor James Macdonald, Herman Borghys, Didier Jean-Claude Berthelot, Michel Anna Jozef De Cleyn, Sven Franciscus Anna Van Brandt
Publikováno v:
Journal of medicinal chemistry. 55(21)
The design and the synthesis of several chemical subclasses of imidazole containing γ-secretase modulators (GSMs) is described. Conformational restriction of pyridone 4 into bicyclic pyridone isosteres has led to compounds with high in vitro and in
Publikováno v:
Molecules
Molecules; Volume 14; Issue 2; Pages: 894-903
MOLECULES
Molecules, Vol 14, Iss 2, Pp 894-903 (2009)
Molecules; Volume 14; Issue 2; Pages: 894-903
MOLECULES
Molecules, Vol 14, Iss 2, Pp 894-903 (2009)
Three analogues of 1α,25-dihydroxyvitamin D 3 (calcitriol), featuring a trans- fused decalin C,D-core with local S 2 -symmetry, and possessing identical side-chain and seco-B,A-ring structures, have been synthesized starting from readily available (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9280ac67efd0fab1feb5bbc021980540
https://lirias.kuleuven.be/handle/123456789/669511
https://lirias.kuleuven.be/handle/123456789/669511
Autor:
Roger Bouillon, Freek Vrielynck, Annemieke Verstuyf, Wim Schepens, Garrett Berlond Minne, Pierre J. De Clercq, Maurits Vandewalle, Dirk Van Haver, Frederik De Buysser
Publikováno v:
ChemInform. 39
Publikováno v:
Molecules, Vol 12, Iss 2, Pp 183-187 (2007)
Molecules
Volume 12
Issue 2
Pages 183-187
Molecules
Volume 12
Issue 2
Pages 183-187
A short and high yielding route for the preparation of the title compound, starting from commercially available 1,5-dihydroxynaphthalene, is described. The key step in the sequence is the air oxidation of a bis(trimethylsilyloxy)diene precursor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9bf6a5f4d7c151c9bf148f3c2cb7f1
https://europepmc.org/articles/PMC6149474/
https://europepmc.org/articles/PMC6149474/
Autor:
Annemieke Verstuyf, Dirk Van Haver, Maurits Vandewalle, Garrett Berlond Minne, Frederik De Buysser, Freek Vrielynck, Roger Bouillon, Pierre J. De Clercq, Wim Schepens
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 103(3-5)
During a 20-year collaboration the laboratories of UGent and KU Leuven have developed different series of Vitamin D analogs characterized by structural modifications in the central CD-ring system. Modifications have first involved the introduction of