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A series of substituted indolo[2,1-a]isoquinolines and indolo[1,2-a]benzoxazines have been prepared, as melatonin analogues, to investigate the nature of the binding site of the melatonin receptor. Agonist and antagonist potency of all the analogues
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https://explore.openaire.eu/search/publication?articleId=od______2127::e434c584321aaa44f7f4881f18dee033
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3220832
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3220832
A series of fluorine substituted methoxyphenylalkyl amides were prepared with different orientations of the fluorine and methoxy groups with respect to the alkylamide side chain and with alkyl sides of differing lengths (n = 1-3). β-Dimethyl and α-
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https://explore.openaire.eu/search/publication?articleId=od______2127::a32e085859aa3aa8e0402d949f05e44f
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3021329
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3021329
Two series of analogues were designed, synthesised and evaluated as potential human melatonin type 1 and 2 receptor (hMT1 and hMT2) ligands. Their biological effects were assessed by a well-established, specific model of melatonin action, the pigment
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https://explore.openaire.eu/search/publication?articleId=od______2127::2bf55692b7ecf403316db9b27dedd656
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3026740
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3026740
Akademický článek
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Autor:
Tsotinis, A., Panoussopoulou, M., Garratt, P.J., Jones, R., Yeh, L-K., Calogeropoulou, Theodora, Sudgen, D.
Publikováno v:
8th Cyprus Conference on New Methods in Drug Research, Limassol, Cyprus 25-30 April, 1999, p. 64
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1457::d7b13ae1ba6791ad98cc9a1c60b9f6c5
http://helios-eie.ekt.gr/EIE/handle/10442/7761
http://helios-eie.ekt.gr/EIE/handle/10442/7761
Autor:
Garratt, P.J. Tsotinis, A.
The functions of melatonin, the hormone of the pineal gland, are of considerable current interest. Synthetic melatonin analogues as agonists and antagonists have been explored in some detail and the molecule can be considered as consisting of an indo
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https://explore.openaire.eu/search/publication?articleId=od______2127::c384d28f6c14b42c6169ba19279a1bf3
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3062521
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3062521
A series of β-substituted and β,β-disubstituted N-acyl 5-methoxy-1-methyltryptamines and 5-methoxytryptamines have been prepared as melatonin analogues to investigate the nature of the binding site of the melatonin receptor. The affinity of analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::09a25784a135e9fe6a7ee612d000b5f1
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3062825
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3062825
A series of aromatic polycationic molecules were synthesised and tested as potential non-classical antiherpes agents. Analogue (4) had a high potency in all four of the HSV cell lines used and is far more potent than ribavirin. The fact that none of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::7bddb3591bc230fc48d23981a4866621
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3063013
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3063013
6H-Isoindolo[2,1-a]indoles (5, 7, 10, 13), 5,6-dihydroindolo[2,1- a]isoquinolines (20, 21), and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles (23, 25, 27, 30) have been prepared as melatonin analogues to investigate the nature of the binding site of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::2bca94d39f2ac4302fded2c0dc3fe3ae
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3023143
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3023143
A series of 2-, 3-, and 4-substituted phenylalkyl amides were prepared as potential melatonin analogs in order to investigate the nature of the binding site of the melatonin receptor in chicken brain. The length of the alkyl chain was systematically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::eca4f1710649cd54f6d5fa3fae215527
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3023437
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3023437